CAS 29782-68-1

Silidianina

Descripción:

Silidianina es un compuesto de flavonolignano derivado principalmente de la planta de cardo mariano, Silybum marianum. Es uno de los constituyentes activos de la silimarina, un complejo de flavonoides conocido por sus propiedades hepatoprotectoras. Silidianina exhibe actividad antioxidante, lo que ayuda a neutralizar los radicales libres y reducir el estrés oxidativo en las células del hígado. Este compuesto se estudia a menudo por sus posibles efectos terapéuticos en enfermedades hepáticas, incluyendo hepatitis y cirrosis, ya que puede promover la regeneración del hígado y mejorar la función hepática. Además, Silidianina ha sido investigado por sus efectos antiinflamatorios y citoprotectores, contribuyendo a sus beneficios generales para la salud. La sustancia se caracteriza típicamente por su solubilidad en disolventes orgánicos y su limitada solubilidad en agua, lo cual es común en muchos flavonoides. Sus propiedades farmacológicas y perfil de seguridad la convierten en un tema de interés en la medicina herbal y los suplementos dietéticos destinados a apoyar la salud del hígado.

Fórmula: C₂₅H₂₂O₁₀

InChI: InChI=1S/C25H22O10/c1-33-16-4-9(2-3-14(16)27)18-11-7-12(20-13(18)8-34-25(20,32)24(11)31)23-22(30)21(29)19-15(28)5-10(26)6-17(19)35-23/h2-7,11,13,18,20,22-23,26-28,30,32H,8H2,1H3/t11-,13-,18+,20+,22+,23-,25-/m1/s1

Clave InChI: InChIKey=CYGIJEJDYJOUAN-JSGXPVSSSA-N

SMILES: O[C@@]12[C@@]3([C@@]([C@H]([C@@](C=C3[C@H]4OC=5C(C(=O)[C@@H]4O)=C(O)C=C(O)C5)(C1=O)[H])C6=CC(OC)=C(O)C=C6)(CO2)[H])[H]

Sinónimos:

• (+)-2,3alpha,3aalpha,7a-Tetrahydro-7aalpha-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3alpha,5,7-trihydroxy-4-oxo-2beta-chromanyl)-3,6-methanobenzofuran-7(6alphaH)-one
• (3R,3aR,6R,7aR)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• 3,6-Methanobenzofuran-7(6H)-one, 4-(3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, [3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-
• 3,6-Methanobenzofuran-7(6H)-one, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, (3R,3aR,6R,7aR,8R)-
• 3,6-Methanobenzofuran-7(6αH)-one, 2,3α,3aα,7a-tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-, (+)-
• 7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• Silidianin [INN]
• Silidianina
• Silidianina [INN-Spanish]
• Silidianine
• Silidianine [INN-French]
• Silidianinum
• Silidianinum [INN-Latin]

Silydianin

CAS: 29782-68-1

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₂₅H₂₂O₁₀

Forma y color: Yellow Powder

Peso molecular: 482.4

Ref: 45-1612641

Silydianin

CAS: 29782-68-1

Fórmula: C₂₅H₂₂O₁₀

Pureza: 95%

Forma y color: Solid

Peso molecular: 482.4362

Ref: IN-DA00BE5C

Silydianin

CAS: 29782-68-1

Silydianin

Fórmula: C₂₅H₂₂O₁₀

Pureza: ≥95%

Peso molecular: 482.44

Ref: 54-BUP02913

Silydianin

CAS: 29782-68-1

Fórmula: C₂₅H₂₂O₁₀

Pureza: ≥ 98.0%

Forma y color: Off-white powder

Peso molecular: 482.44

Ref: 7W-GY6531

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

CAS: 29782-68-1

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

Fórmula: C₂₅H₂₂O₁₀

Pureza: 95%

Peso molecular: 482.44

Ref: 54-OR1023990

Silydianin

CAS: 29782-68-1

Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.

Fórmula: C₂₅H₂₂O₁₀

Pureza: 95%~99%

Peso molecular: 482.441

Ref: BP-BP1307

Silydianin (Standard)

CAS: 29782-68-1

Silydianin (Standard) is a reference standard for research and analysis in studies involving Silydianin. Silydianin (Silidianin) exerts inhibition of UGT in human liver. Silydianin exerts inhibition of OATP1B1, OATP1B3 (unknown origin) expressed in HEK293 cells. Silydianin exerts inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells.

Fórmula: C₂₅H₂₂O₁₀

Forma y color: Solid

Peso molecular: 482.44

Ref: TM-TMSM-2805

Silydianin

Producto controlado

CAS: 29782-68-1

Applications Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.
References Zlelinska-Przyyjemska, M., et al.: Phytother. Res., 20, 115 (2006); Milan, M., et al.L Anal. Chimica. Acta., 486, 125 (2003); Liu, Y.Z., et al.: Chin. Herb. Med., 4, 237 (2012);

Fórmula: C₂₅H₂₂O₁₀

Forma y color: Neat

Peso molecular: 482.44

Ref: TR-S465890

Silydianin

CAS: 29782-68-1

Fórmula: C₂₅H₂₂O₁₀

Peso molecular: 482.45

Ref: 4Z-S-398

Silydianin

CAS: 29782-68-1

Silydianin inhibits UGT, OATP1B1, OATP1B3 in HEK293 cells, and OATP2B1 in MDCK2 cells.

Fórmula: C₂₅H₂₂O₁₀

Pureza: 98.01% - 98.56%

Forma y color: Solid

Peso molecular: 482.44

Ref: TM-T3880

Silydianin

CAS: 29782-68-1

Oxygen-heterocyclic compound

Fórmula: C₂₅H₂₂O₁₀

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 482.44

Ref: 5G-89282

Silydianin

CAS: 29782-68-1

Silydianin is a flavonolignan compound, which is derived from the seeds of the milk thistle plant, Silybum marianum. Its primary mode of action involves antioxidant properties and inhibition of lipid peroxidation. Silydianin contributes to the stabilization of cell membranes, thereby preventing toxins from entering liver cells, and also stimulates the activity of ribosomal RNA, promoting liver cell regeneration.

Fórmula: C₂₅H₂₂O₁₀

Pureza: Min. 95.0 Area-%

Peso molecular: 482.44 g/mol

Ref: 3D-FS42773

Silydianin

CAS: 29782-68-1

Ref: BE-RMCS100013

Silydianin

CAS: 29782-68-1

(3R,3aR,6R,7aR,8R)-7a-Hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-((2R,3R)-3,5,7-trihydroxy-4-oxochroman-2-yl)-3,3a,6,7a-tetrahydro-3,6-methanobenzofuran-7(2H)-one

Fórmula: C₂₅H₂₂O₁₀

Pureza: 95%

Peso molecular: 482.44

Ref: IN-DG151185