CAS 3031-95-6

SAICAR

Descripción:

SAICAR, o N-succinil-5-aminoimidazol-4-carboxamida ribonucleótido, es un compuesto químico involucrado en la vía de biosíntesis de purinas. Se caracteriza por su papel como un intermediario en la síntesis de nucleótidos de purina, específicamente en la conversión de aminoácidos y otros sustratos en nucleótidos de adenina y guanina. El compuesto presenta una estructura de ribonucleótido, que incluye un azúcar ribosa, un grupo carboxamida y un moiety succinilo. SAICAR se encuentra típicamente en sistemas biológicos, particularmente en organismos que utilizan la vía de novo para la síntesis de nucleótidos. Su número CAS, 3031-95-6, es un identificador único que facilita la identificación y el estudio de este compuesto en la literatura científica y bases de datos. El compuesto es de interés en la investigación bioquímica, particularmente en estudios relacionados con vías metabólicas y funciones enzimáticas. Comprender las características de SAICAR y su papel en el metabolismo puede proporcionar información sobre procesos celulares y posibles objetivos terapéuticos en enfermedades relacionadas con el metabolismo de nucleótidos.

Fórmula: C₁₃H₁₉N₄O₁₂P

InChI: InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1

Clave InChI: InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N

SMILES: NC=1N(C=NC1C(N[C@@H](CC(O)=O)C(O)=O)=O)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O

Sinónimos:

• 3031-95-6
• 5-Amino-4-imidazole-N-succinocarboxamide ribonucleotide
• 5-Amino-N-(1,2-dicarboxyethyl)-1-ribofuranosylimidazole-4-carboxamide 5'-Phosphate
• <span class="text-smallcaps">L</smallcap>-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-<smallcap>D</span>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• Aspartic acid, N-[(5-amino-1-β-<span class="text-smallcaps">D</smallcap>-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), <smallcap>L</span>-
• L-aspartic acid, N-[[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• N-(5-Amino-1-ribofuranosylimidazol-4-ylcarbonyl)aspartic acid 5′-phosphate
• N-[(5-Amino-1-ribofuranosylimidazol-4-yl)carbonyl]aspartic Acid 5'-Phosphate
• N-[5-Amino-1-(5'-phosphoribofuranosyl)-4-imidazolecarbonyl]aspartic Acid
• N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic Acid
• N-[[5-Amino-1-(5-O-phosphono-β-<span class="text-smallcaps">D</smallcap>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-<smallcap>L</span>-aspartic acid
• Saicar
• Succino-AICAR
• L-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• Aspartic acid, N-[(5-amino-1-β-D-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), L-

N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazoL-4-yl]carbonyl]-L-aspartic acid

CAS: 3031-95-6

Fórmula: C₁₃H₁₉N₄O₁₂P

Forma y color: Solid

Peso molecular: 454.2833

Ref: IN-DA002ZMH

SAICAR

CAS: 3031-95-6

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).

Fórmula: C₁₃H₁₉N₄O₁₂P

Pureza: 98%

Forma y color: Solid

Peso molecular: 454.28

Ref: TM-T16837

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate

CAS: 3031-95-6

Applications N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate is a metabolite of Purine. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

Fórmula: C₁₃H₁₉N₄O₁₂P

Forma y color: Neat

Peso molecular: 454.28

Ref: TR-S688795

N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate

CAS: 3031-95-6

N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate is a synthetase that is involved in the biosynthesis of purines and pyrimidines. It catalyzes the ATP-dependent formation of N-succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate from succinyl CoA and aspartic acid. This enzyme has been studied in wild type strains of bacteria, such as Escherichia coli, but not in humans or other organisms. N-Succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate has been shown to be an inhibitor of antimicrobial agents such as penicillin G, erythromycin, and tetracycline. The mechanism for this inhibition is unclear, but it may involve hydrogen bonding interactions or structural changes that prevent binding

Fórmula: C₁₃H₁₉N₄O₁₂P

Pureza: Min. 95 Area-%

Forma y color: White Off-White Powder

Peso molecular: 454.28 g/mol

Ref: 3D-NS166064