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CAS 3037216-20-6

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  • Tuspetinib dihydrochloride
    Targetmol
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    Tuspetinib dihydrochloride

    CAS:
    Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).
    Fórmula:C29H35Cl3N6
    Forma y color:Solid
    Peso molecular:573.99

    Ref: TM-T212318