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CAS 3062141-62-9

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  • HDAC/PSMD14-IN-1
    Targetmol
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    HDAC/PSMD14-IN-1

    CAS:
    <p>HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.</p>
    Fórmula:C20H24N4O3S2
    Forma y color:Solid
    Peso molecular:432.56

    Ref: TM-T207215