CAS 30652-11-0

Deferiprona

Descripción:

Deferiprona es un agente quelante sintético utilizado principalmente en el tratamiento de condiciones de sobrecarga de hierro, particularmente en pacientes con talasemia y otras anemias crónicas que requieren transfusiones de sangre frecuentes. Su fórmula química es C10H14N2O5, y funciona al unirse al exceso de hierro en el cuerpo, facilitando su excreción a través de la orina. Deferiprona se caracteriza por su capacidad para formar complejos estables con iones férricos, lo que ayuda a reducir la acumulación de hierro en los tejidos y mitigar las complicaciones asociadas. La sustancia se administra típicamente por vía oral y es conocida por su perfil de efectos secundarios relativamente favorable en comparación con otros quelantes de hierro. Sin embargo, puede causar agranulocitosis, una disminución potencialmente grave en el recuento de glóbulos blancos, lo que requiere un monitoreo regular de los parámetros sanguíneos durante el tratamiento. La eficacia y seguridad de Deferiprona se han establecido a través de varios estudios clínicos, lo que lo convierte en una opción valiosa en el manejo de la sobrecarga de hierro. Su mecanismo de acción único y propiedades farmacocinéticas lo distinguen de otros agentes quelantes, contribuyendo a su papel en la mejora de los resultados de los pacientes en trastornos por sobrecarga de hierro.

Fórmula: C₇H₉NO₂

InChI: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

Clave InChI: InChIKey=TZXKOCQBRNJULO-UHFFFAOYSA-N

SMILES: OC1=C(C)N(C)C=CC1=O

Sinónimos:

• 1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone
• 1,2-Dimethyl-3-hydroxy-4-pyridone
• 1,2-Dimethyl-3-hydroxypyridin-4-one
• 1,2-Dimethyl-3-hydroxypyridine-4-one
• 2-Hydroxy-1,3-Dimethyl-Pyridin-4-One
• 3-Hydroxy-1,2-Dimethyl-4(1H)-Pyridone
• 3-Hydroxy-1,2-dimethyl-1,4-dihydropyridin-4-one
• 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone
• 3-Hydroxy-1,2-dimethyl-4-pyridinone
• 3-Hydroxy-1,2-dimethyl-4-pyridone
• 3-hydroxy-1,2-dimethylpyridin-4(1H)-one
• 4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
• 4(1H)-Pyridone, 3-hydroxy-1,2-dimethyl-
• Apo 66
• CP 20 (chelating agent)
• Cgp 37391
• Cp 20
• Deferione
• Dn 18001Af
• Ferinil
• Ferriprox

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

CAS: 30652-11-0

Fórmula: C₇H₉NO₂

Pureza: >98.0%(GC)(T)

Forma y color: White to Almost white powder to crystal

Peso molecular: 139.15

Ref: 3B-H0944

DEFERIPRONE CRS

CAS: 30652-11-0

DEFERIPRONE CRS

Ref: 41-Y0001976

4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-

CAS: 30652-11-0

Fórmula: C₇H₉NO₂

Pureza: 97%

Forma y color: Solid

Peso molecular: 139.1519

Ref: IN-DA0030RL

Deferiprone

CAS: 30652-11-0

Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

Fórmula: C₇H₉NO₂

Pureza: 99.58% - ≥95%

Forma y color: White Needles

Peso molecular: 139.15

Ref: TM-T1565

Deferiprone

CAS: 30652-11-0

Fórmula: C₇H₉NO₂

Forma y color: White To Off-White Solid

Peso molecular: 139.15

Ref: 4Z-D-501

Deferiprone

CAS: 30652-11-0

Fórmula: C₇H₉NO₂

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 139.15

Ref: 7W-GP5718

Deferiprone

CAS: 30652-11-0

Deferiprone

Pureza: ≥95%

Peso molecular: 139.15g/mol

Ref: 54-BUP18475

Deferiprone

CAS: 30652-11-0

Forma y color: Neat

Ref: 86-MM0975.00

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

CAS: 30652-11-0

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

Pureza: 98%

Peso molecular: 139.15g/mol

Ref: 54-OR322144

Deferiprone

Producto controlado

CAS: 30652-11-0

Applications A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro.
References Kontoghiorghes, G.J.: Lancet I, 817 (1985), Kontoghiorghes, G.J., et al.: Br. J. Haematol., 62, 607 (1986), Kontoghiorghes, G.J., et al.: Biochem. Biophys. Acta, 869, 141 (1986), Kontoghiorghes, G.J., et al.: Arzneim.-Forsch., 37, 1099 (1987),

Fórmula: C₇H₉NO₂

Forma y color: White To Off-White

Peso molecular: 139.15

Ref: TR-D474000

3-Hydroxy-1,2-dimethylpyridin-4(1H)-one

CAS: 30652-11-0

Fórmula: C₇H₉NO₂

Pureza: 97%

Forma y color: White to very pale yellow powder

Peso molecular: 139.154

Ref: 10-F239607

Deferiprone

CAS: 30652-11-0

Deferiprone is a drug used to treat iron overload. It is an organoiron compound that competitively inhibits ferrochelatase, the enzyme responsible for the last step in heme synthesis. Deferiprone prevents the accumulation of iron in tissues and organs, as well as reversing or delaying organ damage caused by excess iron. Deferiprone has been shown to be effective in treating congestive heart failure, cellular physiology disorders, and infectious diseases such as malaria. This drug also has anti-inflammatory properties which may be related to its ability to inhibit prostaglandin synthesis.

Fórmula: C₇H₉NO₂

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 139.15 g/mol

Ref: 3D-FD20884