CAS 30685-43-9

Metildigoxina

Descripción:

Metildigoxina es un glucósido cardíaco, una clase de compuestos conocidos por su capacidad para aumentar la fuerza de las contracciones del corazón y regular el ritmo cardíaco. Se deriva de la digoxina, que se obtiene de la planta dedalera (Digitalis purpurea). Metildigoxina exhibe un mecanismo de acción similar al de otros glucósidos cardíacos, principalmente al inhibir la enzima Na+/K+ ATPasa, lo que lleva a un aumento de los niveles de calcio intracelular y a una mayor contractilidad cardíaca. Este compuesto se utiliza a menudo en el tratamiento de la insuficiencia cardíaca y ciertas arritmias. En términos de su estructura química, Metildigoxina presenta un núcleo esteroide con moieties de azúcar específicas que contribuyen a sus propiedades farmacológicas. El compuesto se administra típicamente de manera controlada debido a su estrecho índice terapéutico, lo que significa que la diferencia entre una dosis efectiva y una dosis tóxica es pequeña. Al igual que con otros glucósidos cardíacos, el monitoreo de los niveles séricos y la respuesta del paciente es crucial para garantizar la seguridad y la eficacia durante el tratamiento.

Fórmula: C₄₂H₆₆O₁₄

InChI: InChI=1/C42H66O14/c1-20-37(49-6)28(43)17-35(50-20)55-39-22(3)52-36(19-30(39)45)56-38-21(2)51-34(18-29(38)44)53-24-11-13-40(4)23(15-24)7-8-25-27(40)16-32(46)41(5)26(12-14-42(25,41)48)31-9-10-33(47)54-31/h9,20-30,32,34-39,43-46,48H,7-8,10-19H2,1-6H3/t20?,21?,22?,23-,24+,25-,26-,27+,28?,29?,30?,32-,34?,35?,36?,37?,38?,39?,40+,41+,42+/m1/s1

Clave InChI: InChIKey=IYJMSDVSVHDVGT-PEQKVOOWSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](OC)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinónimos:

• (3beta,5beta,12beta,17xi)-3-{[2,6-dideoxy-4-O-methyl-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-4-O-methyl-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 4′′′-Methyldigoxin
• 4′′′-O-Methyldigoxin
• 4′′′-β-Methyldigoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-4-O-methyl-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Digoxin, 4′′′-O-methyl-
• Lanirapid
• Lanitop
• Medigoxin
• Methyldigoxin
• beta-Methyldigoxin
• β-Methyldigoxin
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• β-Methyl Digoxin
• -β-Methyl Digoxin
• Metildigoxin RS
• Digoxin, 4'''-O-methyl- (8CI)
• Metildigoxin
• Metildigoxin USP/EP/BP
• 3β-[[4-O-[4-O-(4-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β,14β-card-20(22)-enolide

Metildigoxin

CAS: 30685-43-9

Fórmula: C₄₂H₆₆O₁₄

Forma y color: White To Off-White Solid

Peso molecular: 794.98

Ref: 4Z-M-721

Metildigoxin RS

CAS: 30685-43-9

Forma y color: White To Light Yellowish White Solid Crystalline Powder

Ref: 2K-1162000021

β-Methyl Digoxin

CAS: 30685-43-9

Applications Cardiotonic. Obtained by the O-methylation of Digoxin.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hunter, J., et al.: J. Biol. Chem., 268, 14991 (1993), Greiner, B., et al.: J. Clin. Invest., 104, 147 (1999), Jun, A., et al.: J. Pharm.Pharm. Sci., 4, 263 (2001), Sugiyama, D., et al.: Drug Metab. Dispos., 30, 220 (2002),

Fórmula: C₄₂H₆₆O₁₄

Forma y color: Neat

Peso molecular: 794.97

Ref: TR-M301850

β-Methyldigoxin

CAS: 30685-43-9

B-methyldigoxin is a drug that can be used to study the role of P-gp in drug transport. It has been shown to inhibit P-gp function and thus increase the amount of digoxin transported into the cells. This drug also inhibits cyclooxygenase, which is responsible for the production of prostaglandins, leading to anti-inflammatory effects. B-methyldigoxin has been shown to lower systolic pressure in rats with bowel disease and has been found to have cardiac effects in rats with congestive heart failure. The clinical relevance of this drug is not known, but it may be useful for treating geriatric patients or those with autoimmune diseases, as well as those who have had a cardiac event or are at risk for congestive heart failure.

Fórmula: C₄₂H₆₆O₁₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 794.97 g/mol

Ref: 3D-FM09709

β-Methyl Digoxin

CAS: 30685-43-9

Fórmula: C₄₂H₆₆O₁₄

Peso molecular: 794.97

Ref: ST-EA-CP-D1200012