CAS 30868-30-5

Pirazofurina

Descripción:

Pirazofurina es un análogo de nucleósido sintético con notables propiedades antivirales, que se dirige principalmente a los virus de ARN. Se caracteriza por su estructura de anillo de pirazol, que es esencial para su actividad biológica. El compuesto exhibe un mecanismo de acción que implica la inhibición de la síntesis de ARN viral, lo que lo convierte en un posible agente terapéutico contra diversas infecciones virales. Pirazofurina es soluble en agua y muestra una estabilidad moderada en condiciones fisiológicas. Su perfil farmacológico incluye eficacia antiviral, aunque su uso puede estar limitado por factores como la toxicidad y el desarrollo de resistencia en poblaciones virales. La investigación ha indicado que también puede poseer efectos inmunomoduladores, contribuyendo a su actividad antiviral general. Al igual que con muchos análogos de nucleósidos, la consideración cuidadosa de la dosis y la administración es crucial para maximizar los beneficios terapéuticos mientras se minimizan los efectos adversos. Los estudios en curso continúan explorando sus posibles aplicaciones en el tratamiento de enfermedades virales, particularmente en el contexto de amenazas virales emergentes.

Fórmula: C₉H₁₃N₃O₆

InChI: InChI=1/C9H13N3O6/c10-9(17)4-6(15)3(11-12-4)8-7(16)5(14)2(1-13)18-8/h2,5,7-8,13-16H,1H2,(H2,10,17)(H,11,12)/t2-,5-,7-,8+/m1/s1

Clave InChI: InChIKey=XESARGFCSKSFID-FLLFQEBCSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(O)=C(C(N)=O)NN2

Sinónimos:

• (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-D-ribitol
• (1S)-1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• (1S)-1-{(5Z)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• 1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydropentitol
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-Hydroxy-3-beta-<span class="text-smallcaps">D</span>-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-pyrazole-5-carboxamide
• Antibiotic A 23813
• NSC 143095
• Pirazofurin
• Przf
• Pyrazole-3-carboxamide, 4-hydroxy-5-beta-L-ribofuranosyl-
• Pyrazomycin
• Pyrozofurin
• beta-Pyrazomycin
• β-Pyrazofurin
• β-Pyrazomycin
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-D-ribofuranosyl-
• Pyrazofurin
• 4-Hydroxy-3-β-D-ribofuranosyl-1H-pyrazole-5-carboxamide
• 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
• compound47599
• nsc143095
• 47599
• 4-HYDROXY-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
• A-23813
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
• PYRAZOFURIN MONOHYDRATE

4-HYDROXY-3-β-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE

CAS: 30868-30-5

Fórmula: C₉H₁₃N₃O₆

Pureza: 97%

Forma y color: Solid

Peso molecular: 259.2160

Ref: IN-DA00BE0N

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

CAS: 30868-30-5

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

Pureza: 97%

Peso molecular: 259.22g/mol

Ref: 54-OR1074824

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin is an antiviral drug that inhibits viral DNA synthesis by inhibiting the enzyme ribonucleotide reductase. It has been shown to be effective for bowel disease in mice and murine hepatoma cells. Pyrazofurin binds to the pyrazole ring of the enzyme, thereby inhibiting its activity and preventing the formation of uridine triphosphate (UTP) from uridine monophosphate (UMP). This compound also has anti-cancer activities, which may be due to its ability to inhibit cell growth by targeting enzymes that are expressed at high levels in cancer tissues. Pyrazofurin is used as a biological sample to measure enzyme activities such as dextran sulfate and other substances that can be detected through colorimetric or fluorometric assays.

Fórmula: C₁₁H₁₄F₃N₃O₈

Pureza: Min. 95%

Peso molecular: 373.24 g/mol

Ref: 3D-FBA86830

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).

Fórmula: C₉H₁₃N₃O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 259.22

Ref: TM-T16690