CAS 3094-09-5

Doxifluridina

Descripción:

Doxifluridina, con el número CAS 3094-09-5, es un análogo de pirimidina fluorada utilizado principalmente en la terapia del cáncer. Está estructuralmente relacionado con el nucleósido timidina y funciona como un antimetabolito, inhibiendo la síntesis de ADN al interferir con la acción de la timidilato sintasa. Este mecanismo lo hace particularmente efectivo contra las células cancerosas de rápida división. Doxifluridina se administra típicamente en su forma de profármaco, que se convierte en su metabolito activo dentro del cuerpo. El compuesto presenta un perfil de toxicidad relativamente bajo en comparación con otros agentes quimioterapéuticos, lo que lo convierte en una opción valiosa en terapias combinadas para diversas malignidades. En términos de propiedades físicas, Doxifluridina es un polvo cristalino blanco a blanco amarillento, soluble en agua, y tiene un peso molecular moderado. Su farmacocinética implica procesos de absorción, distribución, metabolismo y excreción que son cruciales para su eficacia terapéutica. En general, Doxifluridina representa una herramienta importante en el arsenal de la farmacoterapia oncológica, particularmente para los cánceres gastrointestinales.

Fórmula: C₉H₁₁FN₂O₅

InChI: InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6?,8?/m1/s1

Clave InChI: InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N

SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2

Sinónimos:

• (2Xi)-5'-Deoxy-5-Fluorouridine
• 5'-Deoxy-5-fluorouridine
• 5'-Dfur
• 5-Fluoro-5'-deoxyuridine
• 5-Fluorodesoxyuridine
• 5′-dFUrd
• Flutron
• Fulturon
• Furtulon
• Ro 21-9738
• Uridine, 5′-deoxy-5-fluoro-
• Doxifluridine
• 5Urd, 5-Fluoro-5deoxyuridine
• Doxifluridine (furtulon)
• 5'-Deoxy-fluorouridine(DFUR)/Doxifluridine
• (+)-5-FLUORO-5'-DEOXYURIDINE 97%
• 5'-DEOXYFLUOROURIDINE
• 5-FLURO-5’-DEOXYURIDINE
• DOXIFLUIRDINE
• 5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738
• Doxifluidine
• DOXIFLURIDINE(SUBJECTTOPATENTFREE)

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 246.19

Ref: 3B-D3579

Capecitabine EP Impurity B

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 246.19

Ref: ST-EA-CP-C52002

CAPECITABINE IMPURITY B CRS

CAS: 3094-09-5

CAPECITABINE IMPURITY B CRS

Fórmula: C₁₅H₂₂FN₃O₆

Peso molecular: 359.3501

Ref: 41-Y0001644

Capecitabine Related Compound B (5'-deoxy-5-fluorouridine)

CAS: 3094-09-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₉H₁₁FN₂O₅

Forma y color: White Powder

Peso molecular: 246.0652

Ref: 45-1090728

Uridine, 5'-deoxy-5-fluoro-

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 246.1924

Ref: IN-DA0031Q7

Doxifluridine

CAS: 3094-09-5

Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.

Fórmula: C₉H₁₁FN₂O₅

Pureza: 99.47% - 99.86%

Forma y color: White Solid

Peso molecular: 246.19

Ref: TM-T1600

5'-DFUR-13C5 (5'-Deoxy-5-fluorouridine, Doxifluridine-13C5)

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 251.22

Ref: 4Z-C-355

Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Forma y color: White To Off-White Solid

Peso molecular: 246.19

Ref: 4Z-C-354

Doxifluridine

CAS: 3094-09-5

Doxifluridine

Pureza: ≥98%

Peso molecular: 246.19g/mol

Ref: 54-BUP19641

1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (5'-Deoxy-5-fluorouridine)

CAS: 3094-09-5

Forma y color: Neat

Ref: 86-MM0992.06

(+)-5-Fluoro-5'-deoxyuridine

CAS: 3094-09-5

(+)-5-Fluoro-5'-deoxyuridine

Fórmula: C₉H₁₁FN₂O₅

Pureza: 98%

Forma y color: white solid

Peso molecular: 246.19g/mol

Ref: 54-PC5775

5-Fluoro-5''-deoxyuridine

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 246.19

Ref: 7W-GP7931

5’-Deoxyfluorouridine-13C,15N2

Producto controlado

CAS: 3094-09-5

Applications 5’-Deoxyfluorouridine-13C,15N2 is a compound useful in organic synthesis.

Fórmula: C₈CH₁₁FN₂O₅

Forma y color: Neat

Peso molecular: 249.17

Ref: TR-D235727

5’-Deoxy-5-fluorouridine

Producto controlado

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B
Applications 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
References Ingle, J., et al.: Cancer, 67, 886 (1991); Harvey, J., et al.: J. Clin. Oncol., 17, 1474 (1999); Asai-Sato, M., et al.: Int. J. Cancer, 115, 539 (2005); Rastelli, F., et al.: Tumori, 94, 370 (2008);

Fórmula: C₉H₁₁FN₂O₅

Forma y color: Neat

Peso molecular: 246.19

Ref: TR-D235725

Doxifluridine

Producto controlado

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B
Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.
References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)

Fórmula: C₉H₁₁FN₂O₅

Forma y color: Neat

Peso molecular: 246.19

Ref: TR-D556750

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

5'-Deoxy-5-fluorouridine (5FU) is a nucleoside that is used in the treatment of cancer. It is an antimetabolite that inhibits the synthesis of DNA, RNA, and proteins by reversibly inhibiting ribonucleotide reductase. 5FU also inhibits epidermal growth factor receptor (EGFR), which leads to apoptosis in cancerous cells. The concentration–time curve for 5FU has been determined using tissue culture and hl-60 cells as biological samples. This drug has been shown to be effective against metastatic colorectal cancer when administered with other chemotherapeutic drugs.

Fórmula: C₉H₁₁FN₂O₅

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 246.2 g/mol

Ref: 3D-ND02968

Doxifluridine

CAS: 3094-09-5

Pureza: 98%

Peso molecular: 246.19

Ref: 10-F787567