CAS 3106-85-2

Ácido N-acetilaspartilglutámico

Descripción:

Ácido N-acetilaspartilglutámico, comúnmente conocido como NAAG, es un dipeptido que ocurre de forma natural compuesto por los aminoácidos N-acetilaspartato y glutamato. Se clasifica como un neurotransmisor y juega un papel significativo en el sistema nervioso central, particularmente en la modulación de la transmisión sináptica y la neuroprotección. Se sabe que NAAG actúa sobre los receptores metabotrópicos de glutamato, influyendo en varios procesos fisiológicos, incluida la percepción del dolor y la neuroplasticidad. La sustancia es soluble en agua y exhibe estabilidad bajo condiciones fisiológicas, lo que la hace relevante para la investigación en neurobiología y aplicaciones terapéuticas potenciales. Su número CAS, 3106-85-2, se utiliza para la identificación en bases de datos químicas. La participación de NAAG en enfermedades neurodegenerativas y su potencial como biomarcador para ciertas condiciones neurológicas son áreas de investigación en curso, destacando su importancia en las ciencias básicas y aplicadas.

Fórmula: C₁₁H₁₆N₂O₈

InChI: InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

Clave InChI: InChIKey=OPVPGKGADVGKTG-BQBZGAKWSA-N

SMILES: [C@@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)(CC(O)=O)NC(C)=O

Sinónimos:

• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-(N-acetyl-<smallcap>L</span>-α-aspartyl)-
• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-acetyl-<smallcap>L</span>-α-aspartyl-
• Ac-Asp-Glu-OH
• Acetyl-α-<span class="text-smallcaps">L</span>-aspartylglutamic acid
• Glutamic acid, N-(N-acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl)-, <smallcap>L</span>-
• Isospaglumic Acid
• N-(N-Acetylaspartyl)glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-α-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-aspartylglutamic acid
• N-Acetylaspartylglutamic acid
• N-acetyl-D-alpha-aspartyl-L-glutamic acid
• N-acetyl-L-alpha-aspartyl-L-glutamic acid
• N-acetyl-alpha-aspartylglutamic acid
• α-Spaglumic acid
• L-Glutamic acid, N-acetyl-L-α-aspartyl-
• Glutamic acid, N-(N-acetyl-L-aspartyl)-, L-
• N-Acetyl-L-α-aspartyl-L-glutamic acid

Ac-Asp-Glu-OH

CAS: 3106-85-2

An endogenous dipeptide with high affinity for a brain glutamate receptor. NAAG is the most abundant peptide neurotransmitter in the mammalian central nervous system.

Fórmula: C₁₁H₁₆N₂O₈

Pureza: > 99%

Forma y color: White Powder

Peso molecular: 304.26

Ref: 01-4006232

L-Glutamic acid, N-acetyl-L-α-aspartyl-

CAS: 3106-85-2

Fórmula: C₁₁H₁₆N₂O₈

Pureza: 95%

Forma y color: Solid

Peso molecular: 304.2533

Ref: IN-DA00321K

N-Acetyl-Asp-Glu

CAS: 3106-85-2

Fórmula: C₁₁H₁₆N₂O₈

Pureza: ≥ 95.0%

Forma y color: White to off-white powder

Peso molecular: 304.25

Ref: 7W-GL2335

Spaglumic acid

CAS: 3106-85-2

Spaglumic acid

Pureza: ≥95%

Peso molecular: 304.25g/mol

Ref: 54-BUP14509

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

CAS: 3106-85-2

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

Pureza: 95%

Peso molecular: 304.25g/mol

Ref: 54-OR1024085

Spaglumic acid

CAS: 3106-85-2

Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in the brain.

Fórmula: C₁₁H₁₆N₂O₈

Pureza: 99.92%

Forma y color: White Powder

Peso molecular: 304.25

Ref: TM-TQ0285

Spaglumic Acid-d3

Producto controlado

CAS: 3106-85-2

Stability Hygroscopic
Applications Spaglumic Acid-d3 is the isotope labelled analogue of Spaglumic Acid, a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Fórmula: C₁₁H₁₃D₃N₂O₈

Forma y color: Neat

Peso molecular: 307.27

Ref: TR-S679102

N-Acetyl-L-aspartyl-L-glutamic acid

CAS: 3106-85-2

N-Acetyl-L-aspartyl-L-glutamic acid is an amino acid that is used as a substrate in the biochemical assay for glutamate. It is also used to measure brain functions. NAAG is a low potency agonist of the NMDA receptor, which may contribute to neuronal death. NAAG is used as a model system to study bowel disease and eosinophil cationic protein. It has been shown to be effective in vitro against cancer cells and fungi. The structural analysis of NAAG has revealed that it contains an acidic group on its side chain, which can be detected with a pH indicator such as phenol red or bromocresol purple.

Fórmula: C₁₁H₁₆N₂O₈

Pureza: Min. 95 Area-%

Forma y color: White Off-White Powder

Peso molecular: 304.25 g/mol

Ref: 3D-FA05316

Spaglumic Acid

Producto controlado

CAS: 3106-85-2

Applications Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Fórmula: C₁₁H₁₆N₂O₈

Forma y color: Neat

Peso molecular: 304.25

Ref: TR-S679100

Ac-Asp-Glu • H2O

CAS: 3106-85-2

Ac-Asp-Glu • H2O is a water soluble molecule that belongs to the class of inhibitors. It has been shown to inhibit the polymerase chain reaction and is used as an analytical method for detecting DNA sequences. Ac-Asp-Glu • H2O induces neuronal death in the caudate putamen, thereby causing bowel disease, by inhibiting energy metabolism. This compound also inhibits the synthesis of proteins in the hippocampus, which leads to reduced locomotor activity and eosinophil cationic protein production. Ac-Asp-Glu • H2O is acidic and its concentration–time curve shows a bell shape. The half life of this compound is six hours.

Fórmula: C₁₁H₁₆N₂O₈•H₂O

Pureza: Min. 95%

Peso molecular: 322.28 g/mol

Ref: 3D-PDE-4167