CAS 31373-65-6

Hippuril-L-histidil-L-leucina

Descripción:

Hippuril-L-histidil-L-leucina, identificado por su número CAS 31373-65-6, es un derivado de dipeptido que consiste en los aminoácidos histidina y leucina unidos por un enlace peptídico a un grupo de ácido hipúrico. Este compuesto exhibe características típicas de los péptidos, incluida la capacidad de participar en varias reacciones e interacciones bioquímicas debido a sus grupos funcionales. Es probable que sea soluble en disolventes polares, como el agua, debido a la presencia de grupos amino y carboxilo que pueden participar en enlaces de hidrógeno. La presencia de histidina contribuye a su capacidad de amortiguación potencial, mientras que la leucina puede mejorar las interacciones hidrofóbicas. Hippuril-L-histidil-L-leucina puede tener aplicaciones en la investigación bioquímica, particularmente en estudios relacionados con la síntesis de péptidos, interacciones proteicas y vías metabólicas. Su estabilidad y reactividad pueden verse influenciadas por factores ambientales como el pH y la temperatura, que son críticos para su comportamiento en sistemas biológicos. En general, este compuesto representa un área fascinante de estudio dentro de la química de péptidos y la bioquímica.

Fórmula: C₂₁H₂₇N₅O₅

InChI: InChI=1S/C21H27N5O5/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31)/t16-,17-/m0/s1

Clave InChI: InChIKey=AAXWBCKQYLBQKY-IRXDYDNUSA-N

SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC(C)C)C(O)=O)=O)NC(CNC(=O)C2=CC=CC=C2)=O

Sinónimos:

• <span class="text-smallcaps">L</smallcap>-Leucine, N-[N-(N-benzoylglycyl)-<smallcap>L</span>-histidyl]-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-benzoylglycyl-<smallcap>L</span>-histidyl-
• Hippuryl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-leucine
• Hippuryl-His-Leu
• Leucine, N-(N-hippuroyl-<span class="text-smallcaps">L</smallcap>-histidyl)-, <smallcap>L</span>-
• N-Benzoylglycyl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-leucine
• N-Benzoylglycyl-L-histidyl-L-leucine
• Hippuryl-L-histidyl-L-leucine
• L-Leucine, N-benzoylglycyl-L-histidyl-
• L-Leucine, N-[N-(N-benzoylglycyl)-L-histidyl]-
• Leucine, N-(N-hippuroyl-L-histidyl)-, L-

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Substrate for a spectrophotometric assay of angiotensin I-converting enzyme. ACE cleavage of Hip-His-Leu yields hippuric acid and His-Leu (G-2310), which can be quantified by generating a fluorescent adduct with o-phthalaldehyde. Schwager et al. developed a high-throughput fluorometric assay for ACE employing Hip-His-Leu.

Fórmula: C₂₁H₂₇N₅O₅

Pureza: ≥ 99%

Forma y color: White Lyophilisate

Peso molecular: 429.48

Ref: 01-4002147

Hippuryl-his-leu-oh

CAS: 31373-65-6

Fórmula: C₂₁H₂₇N₅O₅

Pureza: 98%

Peso molecular: 429.4696

Ref: IN-DA007JNH

(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

CAS: 31373-65-6

(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

Pureza: 98%

Peso molecular: 429.48g/mol

Ref: 54-OR1073976

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Hippuryl-His-Leu-OH tests for angiotensin I enzyme activity, allowing His-Leu detection by fluorescence.

Fórmula: C₂₁H₂₇N₅O₅

Forma y color: Solid

Peso molecular: 429.47

Ref: TM-T76610

Bz-Gly-His-Leu • H2O [Hippuryl-Histidyl-Leucine]

CAS: 31373-65-6

Bz-Gly-His-Leu is a peptide that has the amino acid sequence of Hippuryl-Histidyl-Leucine. The peptide binds to Angiotensin I Converting Enzyme I Substrates and prevents the enzyme from converting Angiotensin I to Angiotensin II, thereby lowering blood pressure. Bz-Gly-His-Leu has been shown to be effective in reducing blood pressure in patients with congestive heart failure as well as those with normal cardiac function.

Fórmula: C₂₁H₂₇N₅O₅•H₂O

Pureza: Min. 95%

Peso molecular: 447.49 g/mol

Ref: 3D-SGL-3064

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Hippuryl-His-Leu-OH is a peptide that inhibits the activity of angiotensin converting enzyme (ACE) at a concentration of 50 μM. It has been shown to inhibit cyclase and other enzymes in vitro. The binding of this compound to ACE prevents the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Hippuryl-His-Leu-OH also has inhibitory properties against atrial natriuretic peptide (ANP), and can be used as an antihypertensive agent. This drug has been shown to have growth factor β1 activities, and can be used for the treatment of cardiac diseases such as myocardial infarction. Structural analysis shows that this drug binds to the active site of ACE, inhibiting its activity by blocking access to substrate or by altering substrate specificity.

Fórmula: C₂₁H₂₇N₅O₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 429.47 g/mol

Ref: 3D-FH110864