CAS 317318-70-0

GW 501516

Descripción:

GW 501516, también conocido como Cardarine, es un compuesto sintético que pertenece a la clase de fármacos conocidos como moduladores selectivos del receptor androgénico (SARMs). Se desarrolló inicialmente para el tratamiento de enfermedades metabólicas y cardiovasculares. GW 501516 funciona como un potente agonista del receptor delta activado por proliferadores de peroxisomas (PPARδ), que desempeña un papel crucial en la regulación del metabolismo de ácidos grasos y la homeostasis energética. Este compuesto es conocido por su potencial para mejorar la resistencia y promover la pérdida de grasa, lo que lo hace popular entre atletas y culturistas, a pesar de su estatus controvertido en el deporte debido a preocupaciones sobre la mejora del rendimiento. GW 501516 ha sido estudiado por sus efectos en los perfiles lipídicos, la sensibilidad a la insulina y la salud metabólica en general. Sin embargo, su seguridad y eficacia a largo plazo en humanos siguen bajo investigación, y no está aprobado para uso médico por las agencias reguladoras. Al igual que con cualquier sustancia, el uso de GW 501516 conlleva riesgos y efectos secundarios potenciales, lo que requiere precaución e investigación exhaustiva antes de su uso.

Fórmula: C₂₁H₁₈F₃NO₃S₂

InChI: InChI=1/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)

Clave InChI: InChIKey=YDBLKRPLXZNVNB-UHFFFAOYSA-N

SMILES: C(SC1=CC(C)=C(OCC(O)=O)C=C1)C=2SC(=NC2C)C3=CC=C(C(F)(F)F)C=C3

Sinónimos:

• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid
• 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
• 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]thiazol-5-yl]methyl]thio]phenoxy]acetic acid
• Acetic acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-
• Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-
• Gw 1516
• Gw 501516
• Gw501516
• [2-Methyl-4-[([4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl)thio]phenoxy]acetic acid
• {2-Methyl-4-[({4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazol-5-Yl}Methyl)Sulfanyl]Phenoxy}Acetic Acid
• GW501516, Free Acid
• ENDUROBOL
• {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid
• Cardarine(GW501516, GSK-516)
• {2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid
• 2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid
• CARDARINE
• GW501516(GSK-516)
• Aceticacid, [2-Methyl-4-[[[4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazolyl]Methyl]thio]phenoxy]-(9CI)
• 2-(4-((2-(4-(TRIFLUOROMETHYL)PHENYL)-5-METHYLTHIAZOL-4-YL)METHYLTHIO)-2-METHYLPHENOXY)ACETIC ACID
• 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
• GW 501516, >=98%
• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic
• GW501516/GW1516/GW-1516/GW501516
• GSK-516
• Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid
• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a
• GW 1516 ,GSK-516
• GW-501615

Cardarine

CAS: 317318-70-0

Forma y color: Neat

Ref: 04-C11041800

GW 501516

CAS: 317318-70-0

Fórmula: C₂₁H₁₈F₃NO₃S₂

Peso molecular: 453.49

Ref: 4Z-G-237004

GW 501516

CAS: 317318-70-0

GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: 98.91% - 99.64%

Forma y color: White Solid

Peso molecular: 453.50

Ref: TM-T6151

GW501516

CAS: 317318-70-0

Ref: 7W-GW9340

GW 501516 - Bio-X ™

Producto controlado

CAS: 317318-70-0

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 453.5 g/mol

Ref: 3D-BG300099

GW 501516

Producto controlado

CAS: 317318-70-0

Agonist of peroxisome proliferator-activated receptor δ/β (PPARδ/β). The compound activates the nuclear receptor PPARδ downstream signalling and affects hepatic AMPK levels. It boosts the activity of the lipin 1-PPARα-PPARγ coactivator 1 (PGC-1)-α pathway and increases hepatic fatty acid oxidation. It was reported that GW 501516 prevents high-fat diet induced hypertriglyceridemia.

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 453.50 g/mol

Ref: 3D-FM23721

GW 501516

Producto controlado

CAS: 317318-70-0

Stability No Data available
Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.
References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017

Fórmula: C₂₁H₁₈F₃NO₃S₂

Forma y color: Neat

Peso molecular: 453.50

Ref: TR-G931500

GW 501516

CAS: 317318-70-0

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: 97%

Forma y color: Solid

Peso molecular: 453.4977

Ref: IN-DA007ION