CAS 32385-11-8

Sisomicina

Descripción:

Sisomicina es un antibiótico aminoglucósido que se utiliza principalmente para tratar infecciones causadas por bacterias Gram-negativas. Se deriva de la fermentación de la bacteria Micromonospora purpurea. Sisomicina exhibe un amplio espectro de actividad antibacteriana, siendo particularmente efectivo contra varias cepas de Pseudomonas y especies de Enterobacter. El mecanismo de acción implica la unión a la subunidad ribosómica 30S, lo que lleva a la inhibición de la síntesis de proteínas, lo que finalmente resulta en la muerte celular bacteriana. Sisomicina se administra típicamente por inyección debido a su mala biodisponibilidad oral. Su farmacocinética incluye excreción renal, lo que requiere ajustes de dosis en pacientes con función renal comprometida. Aunque generalmente es bien tolerado, los efectos secundarios potenciales pueden incluir nefrotoxicidad y ototoxicidad, preocupaciones comunes asociadas con los aminoglucósidos. La estructura química de Sisomicina presenta múltiples grupos amino, lo que contribuye a su solubilidad e interacción con los ribosomas bacterianos. Al igual que con todos los antibióticos, se recomienda realizar pruebas de susceptibilidad adecuadas para garantizar la efectividad contra patógenos específicos.

Fórmula: C₁₉H₃₇N₅O₇·H₂O₄S

InChI: InChI=1/C19H37N5O7.H2O4S/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h3,9-18,24-27H,4-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10+,11-,12+,13?,14-,15+,16-,17-,18-,19+;/m1./s1

Clave InChI: InChIKey=URWAJWIAIPFPJE-YFMIWBNJSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Sinónimos:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-
• Antibiotic 66-40
• Antibiotic 6640
• BactoCeaze
• Ensamycin
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-<span class="text-smallcaps">L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</smallcap>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Rickamicin
• Sch 13475
• Siseptin
• Sisomicin
• Sisomicina
• Sisomicine
• Dehydrogentamicin Cla
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl (2xi)-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-erythro-pentopyranoside sulfate (salt)
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
• Sisomicin base
• 4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)pentopyranoside
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine
• 6-O-(4-C-Methyl-3-methylamino-3-deoxy-β-L-arabinopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-4-hexenopyranosyl)-2-deoxy-D-streptamine
• O-3-Deoxy-4-C-methyl-3-(methylamino)--L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy- D-Streptamine
• Sisomicin (C1a oxidation peak)
• Sisomicin base (intermediates)
• SISOMYCIN
• O-3-deoxy-4C-methyl-3-(methylamino)--L-arabinopiranozyl-(1-6)-O[2,6-diamino-2,3,4,6-tetradeooxy-a-D-glycerohexy-4-enopiranozyl-(1-4)]-2-deoxy-D-streptamycin

Sisomicin

CAS: 32385-11-8

Fórmula: C₁₉H₃₇N₅O₇

Pureza: 97%

Forma y color: Solid

Peso molecular: 447.5264

Ref: IN-DA00C0C4

Sisomicin

CAS: 32385-11-8

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

Fórmula: C₁₉H₃₇N₅O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 447.53

Ref: TM-T20675

Sisomicin (Netilmicin EP Impurity A)

CAS: 32385-11-8

Fórmula: C₁₉H₃₇N₅O₇

Forma y color: White To Off-White Solid

Peso molecular: 447.53

Ref: 4Z-S-080002

Sisomicin

CAS: 32385-11-8

Peso molecular: 447.53

Ref: 7W-GA4392

Sisomicin

Producto controlado

CAS: 32385-11-8

Applications Sisomicin is an Antibacterial. Gentamicin-like aminoglycoside antibiotic; has broad spectrum antibiotic activity.
References Weinstein, M.J., et al.: J. Antibiot., 23, 551 (1970), Sculier, J.P., et al.: J. Antimicrob. Chemother., 9, 63 (1982), Noone, P., et al.: Drugs, 27, 548 (1984),

Fórmula: C₁₉H₃₇N₅O₇

Forma y color: Neat

Peso molecular: 447.53

Ref: TR-S488500

Sisomicin

CAS: 32385-11-8

Sisomicin is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating severe bacterial infections resistant to other aminoglycosides.

Fórmula: C₁₉H₃₇N₅O₇

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 447.53 g/mol

Ref: 3D-AS27839

Netilmicin EP Impurity A

CAS: 32385-11-8

Fórmula: C₁₉H₃₇N₅O₇

Peso molecular: 447.53

Ref: ST-EA-CP-N94001

Sisomicin Sulfate

CAS: 32385-11-8, 53179-09-2

Fórmula: C₁₉H₃₇N₅O₇H₂SO₄

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 692.71

Ref: 3B-I1049