CAS 327-78-6

Isocianato de 4-cloro-3-(trifluorometil)fenilo

Descripción:

Isocianato de 4-cloro-3-(trifluorometil)fenilo, con el número CAS 327-78-6, es un compuesto orgánico caracterizado por su grupo funcional isocianato (-N=C=O) unido a un anillo aromático clorado. Este compuesto presenta un grupo trifluorometilo (-CF3) en la posición meta respecto al grupo isocianato, lo que influye significativamente en su reactividad química y propiedades físicas. Típicamente es un líquido o sólido incoloro a amarillo pálido, dependiendo de la temperatura y pureza. La presencia de los grupos cloro y trifluorometilo mejora su carácter electrofílico, haciéndolo un intermediario útil en la síntesis orgánica, particularmente en la producción de productos farmacéuticos y agroquímicos. Debido a su funcionalidad isocianato, puede reaccionar con aminas y alcoholes, formando ureas y carbamatos, respectivamente. Sin embargo, es importante manejar este compuesto con cuidado, ya que los isocianatos son conocidos por ser tóxicos y pueden causar irritación respiratoria. Se deben tomar las medidas de seguridad adecuadas al trabajar con esta sustancia en un laboratorio o entorno industrial.

Fórmula: C₈H₃ClF₃NO

InChI: InChI=1/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H

Clave InChI: InChIKey=NBJZEUQTGLSUOB-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=CC(N=C=O)=CC=C1Cl

Sinónimos:

• 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide
• 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
• 3-Trifluoromethyl-4-chlorophenyl isocyanate
• 4-Chloro-1-isocyanato-3-trifluoromethylbenzene
• 4-Chloro-3-(trifluoro methyl)phenyl isocyanate
• 4-Chloro-3-(trifluoromethyl)phenylisocyanate
• 4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate
• Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-
• Isocyanic acid, 4-chloro-α,α,α-trifluoro-m-tolyl ester
• Sorafenib intermediate 3
• 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
• 3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE

4-Chloro-3-(trifluoromethyl)phenyl Isocyanate

CAS: 327-78-6

Fórmula: C₈H₃ClF₃NO

Pureza: >98.0%(GC)

Forma y color: White to Almost white powder to lump

Peso molecular: 221.56

Ref: 3B-C2778

4-Chloro-3-(trifluoromethyl)phenyl isocyanate, 97%

CAS: 327-78-6

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Fórmula: C₈H₃ClF₃NO

Pureza: 97%

Forma y color: Crystals or powder or crystalline powder or fused solid or clear liquid as melt, Colorless to white

Peso molecular: 221.56

Ref: 02-L12016

4-Chloro-3-(Trifluoromethyl)Phenyl Isocyanate

CAS: 327-78-6

Fórmula: C₈H₃ClF₃NO

Pureza: 95%

Forma y color: Solid

Peso molecular: 221.5637

Ref: IN-DA0033ZD

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Pureza: 98%

Peso molecular: 221.56g/mol

Ref: 54-PC10386

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Cl-3-(CF3)phenyl isocyanate made from o-chlorobenzotrifluoride and acetic anhydride.

Fórmula: C₈H₃ClF₃NO

Pureza: ≥98%

Forma y color: Solid

Peso molecular: 221.56

Ref: TM-T77702

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Pureza: ≥98%

Peso molecular: 221.56g/mol

Ref: 54-BUP18562

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

Fórmula: C₈H₃ClF₃NO

Pureza: 98%

Forma y color: Solid

Peso molecular: 221.56

Ref: 10-F024252

4-Chloro-3-(trifluoromethyl)phenyl Isocyanate

Producto controlado

CAS: 327-78-6

Applications 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cui, H., et al.: J. Med. Chem., 55, 10948 (2012); Kim, H., et al.: Bull. Kor. Chem. Soc., 34, 2311 (2013)

Fórmula: C₈H₃ClF₃NO

Forma y color: Neat

Peso molecular: 221.56

Ref: TR-C421940

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Chloro-3-(trifluoromethyl)phenyl isocyanate (4CTFPI) is a phenoxy that has significant antiproliferative activity and can be used to treat cancer. It can inhibit the growth of tumor cells by suppressing the production of growth factors and binding to the receptor for these factors, which leads to inhibition of cell division. 4CTFPI also inhibits tumor growth through its ability to induce apoptosis in cancer cells. 4CTFPI has been shown to have antitumor effects on sarcoma cells in vitro and in vivo with a low toxicity profile. This compound is not active against bacterial infections or fungi, but it does not show any carcinogenic effects.

Fórmula: C₈H₃ClF₃NO

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 221.56 g/mol

Ref: 3D-FC03027