CAS 33069-62-4

Paclitaxel

Descripción:

Paclitaxel, con el número CAS 33069-62-4, es un producto natural complejo y un agente quimioterapéutico utilizado principalmente en el tratamiento de varios tipos de cáncer, incluyendo cáncer de ovario, de mama y de pulmón. Se deriva de la corteza del tejo del Pacífico (Taxus brevifolia) y se clasifica como un taxano. Paclitaxel funciona estabilizando los microtúbulos y previniendo su despolimerización, lo que interrumpe el proceso normal de división celular, llevando finalmente a la apoptosis en las células cancerosas. El compuesto se caracteriza por su estructura única, que incluye un sistema de anillo de taxano y varios grupos funcionales que contribuyen a su actividad biológica. Paclitaxel se administra típicamente por vía intravenosa y tiene una solubilidad relativamente baja en agua, a menudo requiriendo formulación con solventes como Cremophor EL para uso clínico. Sus efectos secundarios pueden incluir neutropenia, reacciones de hipersensibilidad y neuropatía periférica. Debido a su eficacia y mecanismo de acción, Paclitaxel sigue siendo una piedra angular en las terapias oncológicas, aunque su uso a menudo va acompañado de un monitoreo cuidadoso y atención de apoyo.

Fórmula: C₄₇H₅₁NO₁₄

InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

Clave InChI: InChIKey=RCINICONZNJXQF-MZXODVADSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinónimos:

• 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
• Abi 007
• Abraxane
• Anzatax
• Apealea
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bms 181339-01
• Capxol
• Coroflex Please
• Cremophor-free paclitaxel
• Cyclopax
• Cynviloq
• Cypher select
• Dhp 107
• Ebetaxel
• EmPAC
• EndoTAG 1
• Genaxol
• Genetaxyl
• Genexol
• Genexol-PM
• Ig 001
• Ig 002
• Infinnium
• Intaxel
• Lep-Etu
• Liposome-entrapped paclitaxel easy-to-use
• Mbt 0206
• Mitotax
• Nab-paclitaxel
• Nanotax
• Nanoxel
• Nk 105
• Nsc 125973
• OncoGel
• Onxal
• Oraxol
• Pacitaxel
• Pacliex
• Padexol
• Paxene
• Pazenir
• Plaxicel
• Qw 8184
• Sindaxel
• TAXUS Express
• TAXUS stent
• Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• TaxAlbin
• Taxal
• Taxol
• Taxol A
• Taxus
• Taxus Liberte
• Tocosol Paclitaxel

Paclitaxel-13C6

Producto controlado

CAS: 33069-62-4

Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Fórmula: C₄₁₁₃C₆H₅₁NO₁₄

Forma y color: Neat

Peso molecular: 859.86

Ref: TR-P132504

Paclitaxel

CAS: 33069-62-4

Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Fórmula: C₄₇H₅₁NO₁₄

Forma y color: Neat

Peso molecular: 853.91

Ref: TR-P132500

Paclitaxel

CAS: 33069-62-4

Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.

Fórmula: C₄₇H₅₁NO₁₄

Pureza: Min. 95%

Forma y color: White Clear Liquid

Peso molecular: 853.91 g/mol

Ref: 3D-FP10637

Paclitaxel in Methanol

CAS: 33069-62-4

Methanol

Ref: BE-BePure-GBW(E)086486-1000

Paclitaxel in Methanol

CAS: 33069-62-4

Methanol

Ref: BE-BePure-GBW(E)086485-100

Paclitaxel

CAS: 33069-62-4

Ref: BE-RMCP002000

Paclitaxel (Taxol, PCXL), 99%

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Pureza: min. 99%

Forma y color: White, Powder

Peso molecular: 853.91

Ref: SR-42883

Paclitaxel

CAS: 33069-62-4

Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.

Fórmula: C₄₇H₅₁NO₁₄

Pureza: Min. 96.0 Area-%

Peso molecular: 853.91 g/mol

Ref: 3D-Q-201533