CAS 330936-70-4

(Gly14)-Humanina (Humana)

Descripción:

(Gly14)-Humanina es un péptido derivado de la proteína mitocondrial humana conocida como Humanina, que está compuesta por 24 aminoácidos. Este péptido es notable por sus propiedades neuroprotectoras y sus posibles roles en la supervivencia celular y el metabolismo. La modificación en la posición 14, donde la glicina es sustituida, mejora su estabilidad y bioactividad. La Humanina y sus análogos, incluido (Gly14)-Humanina, han sido estudiados por sus efectos en varios procesos celulares, incluyendo la apoptosis, la inflamación y la señalización de insulina. El número CAS 330936-70-4 identifica este péptido específico en bases de datos químicas, facilitando la investigación y el desarrollo en aplicaciones biomédicas. Característicamente, (Gly14)-Humanina exhibe un tamaño molecular relativamente pequeño, es soluble en soluciones acuosas y puede interactuar con receptores específicos para ejercer sus efectos biológicos. Sus posibles implicaciones terapéuticas están siendo exploradas en el contexto de enfermedades neurodegenerativas, trastornos metabólicos y condiciones relacionadas con la edad, lo que lo convierte en un tema de interés tanto en la investigación farmacológica como clínica.

[Gly14]-Humanin

CAS: 330936-70-4

Humanin is an endogenous peptide which is encoded for by mitochondrial DNA. It has been described as a rescue factor due to it demonstrating the capabilities of abolishing neuronal cell death, therefore is can be used to as a potential treatment of Alzheimer’s disease. Another function of Humanin is it can inhibit mitochondira-dependent apoptosis through preventing the formation of apoptotic bodies and the release of Cytochrome C.
Humanin has been found to be related to aging related cardiovascular disease (ACVDs) due to evidence of Humanin serum levels as age increases. Furthermore Humanin increases the expression of antioxidant defense system proteins and impedes complexes I and III from their activity in the electron transport chain in myocardial cells and mitochondria, therefore decreasing oxidative stress damage caused by H2O2. Humanin further reduces reactive oxygen species production and protects cardiomyocytes and fibroblasts, from oxidative stress.
Overall Humanin has a variety of protective functions such as mitochondrial homeostasis and redox systems regulation, anti-aging, prevention of myocardial fibrosis, anti-inflammation, metabolism improvement and autophagy promotion. It has also been found to improve beta-cell survival and thus can be used as a diabetes treatment due to it improving insulin secretion and resistance.
This Humanin product has had the serine at position 14 on the amino acid chain replaced with a Glycine. This modification has been known to enhance the cytoprotective activity of Humanin by 1000 fold and proves to be highly anti-apoptotic. Therefore this product is of scientific interest for research laboratories. It is available as a 0.5mg vial.

Fórmula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Pureza: Min. 95%

Peso molecular: 2,657.2 g/mol

Ref: 3D-PHN-4385-V

(Gly14)-Humanin (human) trifluoroacetate salt

CAS: 330936-70-4

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Fórmula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Pureza: Min. 95%

Peso molecular: 2,657.21 g/mol

Ref: 3D-FG109548

(Gly¹⁴)-Humanin (human)

CAS: 330936-70-4

S14G-Humanin (HNG) is a more potent neuroprotective factor than native humanin. In middle-aged APPswe/PS1dE9 mice, the mutant peptide improved cognitive deficits and reduced amyloid pathology. S14G-Humanin inhibited Aβ 1-42 fibril formation, disaggregates preformed fibrils, and protects against Abeta-induced cytotoxicity in vitro.

Fórmula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Pureza: > 95%

Forma y color: White Powder

Peso molecular: 2657.25

Ref: 01-4038277