CAS 33279-57-1

k-Estrofantosido

Descripción:

k-Estrofantosido, con el número CAS 33279-57-1, es un glucósido cardíaco derivado de las semillas del género Strophanthus, particularmente de Strophanthus gratus. Se caracteriza por su capacidad para inhibir la enzima Na+/K+ ATPasa, lo que lleva a un aumento de las concentraciones intracelulares de sodio y calcio, mejorando en última instancia la contractilidad cardíaca. Este compuesto exhibe una estructura que incluye un núcleo esteroide con un grupo de azúcar, lo que contribuye a su actividad biológica. k-Estrofantosido es conocido por sus posibles aplicaciones terapéuticas en el tratamiento de afecciones cardíacas, particularmente insuficiencia cardíaca y arritmias, debido a sus efectos inotrópicos positivos. Sin embargo, también tiene una ventana terapéutica estrecha, lo que requiere un monitoreo cuidadoso de la dosis para evitar toxicidad. La sustancia se administra típicamente en un entorno médico controlado, y su farmacocinética puede verse influenciada por varios factores, incluidas variables específicas del paciente y medicamentos concurrentes. Al igual que con otros glucósidos cardíacos, es esencial considerar los posibles efectos secundarios, como trastornos gastrointestinales y arritmias, al evaluar su uso en la práctica clínica.

Fórmula: C₄₂H₆₄O₁₉

InChI: InChI=1/C42H64O19/c1-19-36(61-38-35(51)33(49)31(47)27(60-38)17-56-37-34(50)32(48)30(46)26(15-43)59-37)25(54-3)13-29(57-19)58-21-4-9-40(18-44)23-5-8-39(2)22(20-12-28(45)55-16-20)7-11-42(39,53)24(23)6-10-41(40,52)14-21/h12,18-19,21-27,29-38,43,46-53H,4-11,13-17H2,1-3H3/t19-,21+,22?,23+,24-,25+,26-,27-,29+,30-,31-,32+,33+,34-,35-,36-,37-,38+,39-,40+,41+,42+/m1/s1

Clave InChI: InChIKey=GILGYKHFZXQALF-FBPIOBPTSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@]1(O)C[C@@H](O[C@H]6C[C@H](OC)[C@H](O[C@@H]7O[C@H](CO[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](C)O6)CC2)[H])[H]

Sinónimos:

• (3beta,5beta)-3-((O-beta-D-glucopyranosyl-(1.6)-O-beta-D-glucopyranosyl-(1.4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,17xi)-3-{[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl]oxy}-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3β,5β)-3-[(O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-(1→6)-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• 3-{[hexopyranosyl-(1->6)hexopyranosyl-(1->4)-2,6-dideoxy-3-O-methylhexopyranosyl]oxy}-5,14-dihydroxy-19-oxocard-20(22)-enolide
• 5-beta-Card-20(22)-enolide, 3-beta-((O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl-(1-4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-
• Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl-(1-4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)- (9CI)
• Card-20(22)-enolide, 3-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• Nsc 7530
• Strophanthidin + cymarose + beta-glucose + alpha-glucose
• Strophanthidin + cymarose + beta-glucose + alpha-glucose [German]
• Strophanthoside-K
• k-Strofantozyd
• k-Strofantozyd [Polish]
• k-Strophanthidin-gamma
• k-Strophanthoside
• k-Strophantosid
• k-Strophantosid [German]
• k-Strophantoside
• (3β,5β)-3-[(O-β-D-Glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• copyranosyl-(1-4)-2,6-dideoxy-3-o-methyl-beta-d-ribo-hexopyranosyl)oxy)-5,14-d
• K-strophanthin variable mixture
• 3β-[4-O-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]-2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyloxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide
• STROPHANTHOSIDE, K-(RG)
• Strophanthosid-K
• ihydroxy-19-oxo-

K-Strophanthoside

CAS: 33279-57-1

K-Strophanthoside analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₄₂H₆₄O₁₉

Pureza: (HPLC) ≥90%

Forma y color: Powder

Peso molecular: 872.96

Ref: 11-0858

K-strophanthoside

CAS: 33279-57-1

Natural glycoside

Fórmula: C₄₂H₆₄O₁₉

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 872.96

Ref: 5G-82206

K-Strophanthoside

CAS: 33279-57-1

K-Strophanthoside is a cardiac glycoside, which is a bioactive compound derived from the seeds of certain Strophanthus species, a genus of plants native to Africa. This compound exhibits its mode of action by inhibiting the sodium-potassium ATPase enzyme on cell membranes, leading to an increase in intracellular sodium levels. Consequently, the sodium-calcium exchanger is affected, resulting in elevated intracellular calcium concentrations. This cascade enhances cardiac contractility, which can be beneficial in treating certain types of heart failure.

Fórmula: C₄₂H₆₄O₁₉

Pureza: Min. 95%

Peso molecular: 872.9 g/mol

Ref: 3D-IBA27957

k-Strophanthoside

CAS: 33279-57-1

k-Strophanthoside is a natural product for research related to life sciences. The catalog number is TN4362 and the CAS number is 33279-57-1.

Fórmula: C₄₂H₆₄O₁₉

Pureza: 98%

Forma y color: Solid

Peso molecular: 872.95

Ref: TM-TN4362