CAS 33419-42-0

Etopósido

Descripción:

Etopósido es un agente quimioterapéutico utilizado principalmente en el tratamiento de varios tipos de cáncer, incluyendo el cáncer testicular y el cáncer de pulmón de células pequeñas. Se clasifica como un inhibidor de la topoisomerasa II, lo que significa que interfiere con la enzima responsable de la replicación y reparación del ADN, lo que finalmente conduce a la muerte de las células cancerosas. Etopósido se administra típicamente por vía intravenosa u oral y es conocido por su efectividad en combinación con otros fármacos de quimioterapia. El compuesto tiene una fórmula molecular de C21H22O8 y un peso molecular de aproximadamente 366.39 g/mol. Etopósido se caracteriza por su capacidad para inducir apoptosis en las células cancerosas, lo que lo convierte en una herramienta valiosa en oncología. Sin embargo, también puede causar efectos secundarios, incluyendo mielosupresión, trastornos gastrointestinales y un mayor riesgo de malignidades secundarias. Debido a su mecanismo de acción, el monitoreo y la gestión cuidadosa de la dosis son esenciales para minimizar la toxicidad mientras se maximiza la eficacia terapéutica. En general, Etopósido sigue siendo un agente importante en el arsenal contra ciertas malignidades.

Fórmula: C₂₉H₃₂O₁₃

InChI: InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

Clave InChI: InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(O)C(OC)=C7)[H]

Sinónimos:

• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
• 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
• 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
• 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
• 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
• 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
• 4′-Demethyl-1-O-[4,6-O-(ethylidene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]epipodophyllotoxin
• 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• 4′-Demethylepipodophyllotoxin ethylidene-β-<span class="text-smallcaps">D</span>-glucoside
• Beposid
• Bioposide
• Celltop
• EPE
• Epipodophyllotoxin VP 16213
• Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-β-D-glucopyranoside
• Epipodophyllotoxin, 4′-demethyl-, 4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Eposed
• Eposin
• Ethopul
• Eto-Gry
• Etoposid
• Etoposido
• Etosid
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahy dro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Fytop
• Fytosid
• Lastet
• Nsc 141540
• Nzytop
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• Sintopozid
• Topok
• Toposar
• Toposide
• VP 16 (pharmaceutical)
• VePesid
• Vepesid J
• Vp 16
• Vp 16-123
• Vp 16-213
• Zuyeyidal
• trans-Etoposide
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Etoposide-d4

Producto controlado

CAS: 33419-42-0

Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. Antineoplastic.
References Burden, D.A., et al.: J. Biol. Chem., 271, 29238 (1996), Joel, S., et al.: Cancer Treat. Rev., 22, 179 (1996),

Fórmula: C₂₉H₂₈D₄O₁₃

Forma y color: Neat

Peso molecular: 592.58

Ref: TR-E933753

Etoposide-d3

Producto controlado

CAS: 33419-42-0

Applications A labelled DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. Antineoplastic.
References Burden, D.A., et al.: J. Biol. Chem., 271, 29238 (1996), Joel, S., et al.: Cancer Treat. Rev., 22, 179 (1996),

Fórmula: C₂₉H₂₉D₃O₁₃

Forma y color: Neat

Peso molecular: 591.58

Ref: TR-E933752

Etoposide

CAS: 33419-42-0

Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition of DNA topoisomerase II, thus catalysing cell cycle arrest and apoptosis.

Fórmula: C₂₉H₃₂O₁₃

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 588.55 g/mol

Ref: 3D-ME09941

Etoposide - Bio-X ™

CAS: 33419-42-0

Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition of DNA topoisomerase II, thus catalysing cell cycle arrest and apoptosis. 
Etoposide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₉H₃₂O₁₃

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 588.56 g/mol

Ref: 3D-BE164434

Etoposide-[13C,d3]

CAS: 33419-42-0

Ref: BE-MCD-7346

Etoposide (Standard)

CAS: 33419-42-0

Etoposide (Standard) is a reference standard for research and analysis in studies involving Etoposide. Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.

Fórmula: C₂₉H₃₂O₁₃

Forma y color: Solid

Peso molecular: 588.56

Ref: TM-TMSM-3462

Etoposide-d4

Producto controlado

CAS: 33419-42-0

Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition of DNA topoisomerase II, thus catalysing cell cycle arrest and apoptosis. This compoud, Etoposide-d4, is a deuterated form of the drug.

Fórmula: C₂₉H₃₂O₁₃

Pureza: Min. 95%

Ref: 3D-ME45909

Etoposide

CAS: 33419-42-0

Fórmula: C₂₉H₃₂O₁₃

Peso molecular: 588.6

Ref: ST-EA-CP-E31000

Etoposide

Producto controlado

CAS: 33419-42-0

Fórmula: C₂₉H₃₂O₁₃

Forma y color: Neat

Peso molecular: 588.56

Ref: 86-MM0492.00

Etoposide RS

CAS: 33419-42-0

Forma y color: White

Ref: 2K-1025000021