CAS 3385-03-3

Flunisolida

Descripción:

Flunisolida es un corticosteroide sintético utilizado principalmente por sus propiedades antiinflamatorias, particularmente en el tratamiento de condiciones respiratorias como el asma y la rinitis alérgica. Se caracteriza por su capacidad para inhibir la liberación de mediadores inflamatorios, reduciendo así la inflamación y los síntomas asociados. Flunisolida se administra típicamente por inhalación o spray nasal, permitiendo efectos localizados con una mínima absorción sistémica. El compuesto tiene una fórmula molecular que refleja su estructura esteroidal, que es esencial para su actividad biológica. Exhibe una lipofilia moderada, facilitando su penetración en los tejidos objetivo. La farmacocinética de Flunisolida implica un metabolismo rápido, principalmente en el hígado, y se excreta principalmente a través de la orina. Los efectos secundarios comunes pueden incluir irritación local, dolor de cabeza o malestar nasal, pero los efectos sistémicos generalmente se minimizan debido a su entrega dirigida. Al igual que con todos los corticosteroides, el uso a largo plazo requiere un monitoreo cuidadoso para evitar complicaciones potenciales, como la supresión adrenal o la osteoporosis. En general, Flunisolida es un agente terapéutico eficaz en el manejo de condiciones inflamatorias, particularmente en el tracto respiratorio.

Fórmula: C₂₄H₃₁FO₆

InChI: InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1

Clave InChI: InChIKey=XSFJVAJPIHIPKU-XWCQMRHXSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C([C@@H](F)C4)=CC(=O)C=C5)[H])[H])[H]

Sinónimos:

• (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
• 6α-Fluoro-11β,21-dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
• Aerobid
• Aerobid M
• Bronalide
• Flunisolid
• Flunisolida
• Flunisolide
• Lunis
• Nasalide
• Nasarel
• Nisolid
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
• Rhinalar
• Rs 3999
• Soluzione
• Synaclyn
• Syntaris
• UNII-78M02AA8KF
• (6bS,9aR,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• Flunisolidum [INN-Latin]
• Flunisolide [INN]
• Flunisolide HFA
• Aerospan
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
• 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone
• (4aR,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• Flunisolida [INN-Spanish]
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
• Flunisolidum
• Aerospan HFA
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one hydrate (2:1)

Flunisolide

CAS: 3385-03-3

Fórmula: C₂₄H₃₁FO₆

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 434.50

Ref: 3B-F0437

Flunie

CAS: 3385-03-3

Fórmula: C₂₄H₃₁FO₆

Peso molecular: 434.50

Ref: 7W-GK1555

Flunisolide

Producto controlado

CAS: 3385-03-3

Fórmula: C₂₄H₃₁FO₆

Forma y color: White To Light Yellow

Peso molecular: 434.50

Ref: 04-C13726600

Flunisolide

Producto controlado

CAS: 3385-03-3

Applications Flunisolide is a synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chu, N.I., et al.: Drug Metab. Dispos., 7, 81 (1979), Pakes, G.E., et al.: Drugs, 19, 397 (1980)

Fórmula: C₂₄H₃₁FO₆

Forma y color: White To Light Yellow

Peso molecular: 434.5

Ref: TR-F500485

Flunisolide-d6

Producto controlado

CAS: 3385-03-3

Fórmula: C₂₄₂H₆H₂₅FO₆

Forma y color: Neat

Peso molecular: 440.53

Ref: TR-F500487

Flunisolide

Producto controlado

CAS: 3385-03-3

Flunisolide is a corticosteroid that relieves the symptoms of allergy, such as nasal congestion, sneezing, and runny nose. It also reduces levels of cortisol in the blood and may be used to treat asthma. Flunisolide is rapidly absorbed through the nasal mucosa and has been shown effective in vitro at inhibiting allergic reactions. Clinical trials have demonstrated long-term efficacy with flunisolide in the treatment of allergic rhinitis and asthma. Flunisolide has been shown to inhibit eosinophil cationic protein (ECP) synthesis and reduce airway hyperresponsiveness in asthmatic subjects. The chemical stability of flunisolide has been tested by exposing it to human serum for up to 24 hours at 37°C with no loss of activity. In addition, flunisolide does not cause skin irritation or local erythema on repeated topical applications to humans or animals. A two-way crossover study

Fórmula: C₂₄H₃₁FO₆

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 434.5 g/mol

Ref: 3D-FF23333

Flunisolide-d4 (major)

Producto controlado

CAS: 3385-03-3

Applications Flunisolide-d4 is the labeled analogue of Flunisolide (F500485), a synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.
References Chu, N.I., et al.: Drug Metab. Dispos., 7, 81 (1979); Pakes, G.E., et al.: Drugs, 19, 397 (1980)

Fórmula: C₂₄D₄H₂₇FO₄

Forma y color: Neat

Peso molecular: 406.524

Ref: TR-F500489