CAS 34552-83-5

Clorhidrato de loperamida

Descripción:

Clorhidrato de loperamida es un agonista de los receptores opioides que se utiliza principalmente como medicamento antidiarreico. Funciona al ralentizar la motilidad intestinal, lo que aumenta el tiempo que las sustancias permanecen en los intestinos, permitiendo una mayor absorción de agua y resultando en heces más firmes. La sustancia se administra típicamente en su forma de sal hidrocloruro, lo que mejora su solubilidad y estabilidad. La loperamida se caracteriza por su relativamente baja biodisponibilidad cuando se toma por vía oral, ya que sufre un metabolismo de primer paso significativo en el hígado. Generalmente es bien tolerada, pero los efectos secundarios potenciales pueden incluir estreñimiento, mareos y malestar abdominal. Es importante destacar que la loperamida no penetra eficazmente la barrera hematoencefálica, lo que minimiza su potencial de abuso en comparación con otros opioides. La estructura química presenta un anillo de piperidina, que contribuye a sus propiedades farmacológicas. Al igual que con cualquier medicamento, es esencial usar la loperamida según lo indicado para evitar complicaciones, como megacolon tóxico o estreñimiento severo, particularmente en casos de infecciones bacterianas.

Fórmula: C₂₉H₃₃ClN₂O₂·ClH

InChI: InChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

Clave InChI: InChIKey=PGYPOBZJRVSMDS-UHFFFAOYSA-N

SMILES: C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C(N(C)C)=O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

Sinónimos:

• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, hydrochloride
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, monohydrochloride
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, hydrochloride (1:1)
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, monohydrochloride
• 4-(4-(p-Chlorophenyl)-4-hydroxy-1-piperidyl)-N,N-dimethyl-2,2-diphenylbutyramide HCl
• 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenylpiperidine-1-butyramide monohydrochloride
• 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide HCl
• 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide monohydrochloride
• 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinobutyramide hydrochloride
• 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride (1:1)
• Arret
• Blox
• Brek
• Dissenten
• Fortasec
• Imodium
• Imodium A-D
• Imodium A-D EZ chews
• Imosec
• Imossel
• Lopemid
• Lopemin
• Loperamide HCl
• Loperazine
• Loperyl
• Lopodium
• Maalox Antidiarrheal
• NSC 696356
• Pj 185
• Pj185
• R 18553
• Suprasec
• Tebloc
• Unii-77Ti35393C
• Up and up anti diarrheal

Loperamide Hydrochloride

CAS: 34552-83-5, 53179-11-6

Fórmula: C₂₉H₃₃ClN₂O₂·HCl

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 513.50

Ref: 3B-L0154

Loperamide hydrochloride, 98+%

CAS: 34552-83-5

At nanomolar concentrations, binds to mu-opioid receptors. L-type calcium channel blocker This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product /

Fórmula: C₂₉H₃₄Cl₂N₂O₂

Pureza: 98+%

Forma y color: Powder, White to off-white

Peso molecular: 513.50

Ref: 02-J60168

Loperamide.HCl, 1mg/ml in Methanol (as free base)

CAS: 34552-83-5

Forma y color: Single Solution

Ref: LP-LPR-1789-HC-1LM

Loperamide Hydrochloride

CAS: 34552-83-5

Forma y color: Neat

Ref: 61-FOR0025.00

LOPERAMIDE HYDROCHLORIDE CRS

CAS: 34552-83-5

LOPERAMIDE HYDROCHLORIDE CRS

Fórmula: C₂₉H₃₄Cl₂N₂O₂

Forma y color: White. Powder.

Peso molecular: 513.4985

Ref: 41-L0750000

Loperamide hydrochloride

CAS: 34552-83-5

Loperamide hydrochloride

Fórmula: C₂₉H₃₃ClN₂O₂HCl

Pureza: 98.9%

Forma y color: White Solid

Peso molecular: 512.19973

Ref: 47-635

LOPERAMIDE HYDROCHLORIDE RS

CAS: 34552-83-5

LOPERAMIDE HYDROCHLORIDE RS

Fórmula: C₂₉H₃₄Cl₂N₂O₂

Peso molecular: 513.4985

Ref: 41-ICRS0340

LOPERAMIDE FOR SYSTEM SUITABILITY CRS

CAS: 34552-83-5

LOPERAMIDE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002087

Loperamide Hydrochloride

CAS: 34552-83-5

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₂₉H₃₃ClN₂O₂·HCl

Forma y color: White Yellow Powder

Peso molecular: 476.22306

Ref: 45-1370000

Loperamide Hydrochloride

CAS: 34552-83-5

Fórmula: C₂₉H₃₄Cl₂N₂O₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 513.4985

Ref: IN-DA003RD3

Loperamide hydrochloride

CAS: 34552-83-5

Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.

Fórmula: C₂₉H₃₄Cl₂N₂O₂

Pureza: 99.91% - >99.99%

Forma y color: Crystals Practically Insoluble In Water

Peso molecular: 513.50

Ref: TM-T0209

Loperamide hydrochloride

CAS: 34552-83-5

Loperamide hydrochloride

Pureza: ≥98%

Peso molecular: 513.498g/mol

Ref: 54-BUP16718

Loperamide Hydrochloride

CAS: 34552-83-5

Loperamide Hydrochloride

Pureza: 98%

Ref: 54-OR1029186

Loperamide hydrochloride

CAS: 34552-83-5

Fórmula: C₂₉H₃₃ClN₂O₂·HCl

Pureza: ≥ 98.0% (dried basis)

Forma y color: White to almost white powder

Peso molecular: 513.51

Ref: 7W-GP1101

Loperamide hydrochloride, USP

CAS: 34552-83-5

Fórmula: C₂₉H₃₃ClN₂O₂·HCl

Pureza: (HPLC) 98.0 - 102.0 % (on dried basis)

Forma y color: White to almost white powder

Peso molecular: 513.51

Ref: 7W-GP1953

Loperamide HCl

CAS: 34552-83-5

Fórmula: C₂₉H₃₃ClN₂O₂·HCl

Forma y color: White To Off-White Solid

Peso molecular: 513.51

Ref: 4Z-L-091

Loperamide.HCl

CAS: 34552-83-5

Forma y color: Neat

Ref: LP-LPR-1789-HC-10

Loperamide Hydrochloride

CAS: 34552-83-5

Forma y color: Neat

Ref: 86-MM0025.00

Loperamide hydrochloride

Producto controlado

CAS: 34552-83-5

Fórmula: C₂₉H₃₃ClN₂O₂·ClH

Forma y color: Neat

Peso molecular: 513.50

Ref: 04-C14647000

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride

CAS: 34552-83-5

Pureza: 98.0%

Forma y color: Solid

Peso molecular: 513.5

Ref: 10-F358128

Loperamide Hydrochloride

CAS: 34552-83-5

Applications Used as an antidiarrheal.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973), Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990),

Fórmula: C₂₉H₃₃ClN₂O₂·ClH

Forma y color: White To Off-White

Peso molecular: 513.50

Ref: TR-L469450

Loperamide hydrochloride

Producto controlado

CAS: 34552-83-5

μ-opioid receptor agonist; calcium channel inhibitor; anti-diarrheal

Fórmula: C₂₉H₃₃ClN₂O₂•HCl

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 513.5 g/mol

Ref: 3D-FL24925

Loperamide hydrochloride - Bio-X ™

Producto controlado

CAS: 34552-83-5

Loperamide is an antidiarrheal agent used to control chronic diarrhea causing by inflammatory bowel disease. This drug is a Mu-type opioid receptor agonist and also inhibits the release of prostaglandins and acetylcholine to allow an increase in intestinal transit time.

Fórmula: C₂₉H₃₄Cl₂N₂O₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 513.5 g/mol

Ref: 3D-BL166178