CAS 345909-35-5

Ácido 4-hidroxiquinolina-2-carboxílico hidratado

Descripción:

Ácido 4-hidroxiquinolina-2-carboxílico hidratado es un compuesto orgánico caracterizado por su estructura de quinolina, que presenta un grupo hidroxilo y un grupo funcional de ácido carboxílico. Este compuesto típicamente aparece como un sólido cristalino y es conocido por sus posibles aplicaciones en farmacéutica y bioquímica, particularmente como un bloque de construcción en la síntesis de diversas moléculas bioactivas. La presencia del grupo hidroxilo contribuye a su solubilidad en disolventes polares, mientras que el grupo ácido carboxílico puede participar en enlaces de hidrógeno y otras interacciones, mejorando su reactividad. La forma hidratada indica que contiene moléculas de agua en su estructura cristalina, lo que puede influir en sus propiedades físicas, como el punto de fusión y la solubilidad. Además, Ácido 4-hidroxiquinolina-2-carboxílico hidratado puede exhibir actividad biológica, lo que lo hace de interés en química medicinal e investigación relacionada con propiedades antimicrobianas o antiinflamatorias. Al igual que muchos compuestos orgánicos, el manejo y almacenamiento adecuados son esenciales para mantener su estabilidad y eficacia.

Fórmula: C₁₀H₆NO₃

InChI: InChI=1/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1

SMILES: c1ccc2c(c1)c(=O)cc(C(=O)[O-])[nH]2

Sinónimos:

• 4-hydroxy-Quinaldate
• 4-Hydroxyquinaldate
• 4-Hydroxyquinaldinate
• 4-Hydroxyquinoline-2-carboxylate
• Kynurenate
• 4-Oxo-1,4-Dihydroquinoline-2-Carboxylate

Kynurenic Acid

CAS: 345909-35-5, 492-27-3

Fórmula: C₁₀H₇NO₃

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Gray to Brown powder to crystal

Peso molecular: 189.17

Ref: 3B-H0303

4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

CAS: 345909-35-5

Broad spectrum excitatory amino acid antagonist4-Hydroxyquinoline-2-carboxylic acid hydrate is used as an intermediate in synthetic chemistry. It acts as an antiexcitotoxic and anticonvulsant. It finds application in certain neurobiological disorders therapy. This Thermo Scientific Chemicals brand

Fórmula: C₁₀H₇NO₃

Pureza: 98%

Forma y color: Dark cream to cream to yellow to green to pale brown to pale gray to gray, Powder

Peso molecular: 189.17

Ref: 02-A12602

4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID, HYDRATE, 98

CAS: 345909-35-5

Fórmula: C₁₀H₉NO₄

Pureza: 95%

Forma y color: Solid

Peso molecular: 207.1828

Ref: IN-DA003LJW

4-Hydroxyquinoline-2-carboxylic acid hydrate

CAS: 345909-35-5

4-Hydroxyquinoline-2-carboxylic acid hydrate

Fórmula: C₁₀H₇NO₃·H₂O

Pureza: ≥95%

Forma y color: faint yellow/ green solid

Peso molecular: 207.18g/mol

Ref: 54-OR12784

4-Hydroxyquinoline-2-carboxylic acid hydrate

CAS: 345909-35-5

4-Hydroxyquinoline-2-carboxylic acid hydrate is a neuroprotective agent that has been shown to be effective in the treatment of neurodegenerative diseases. It is a solvate, which means that it can form crystals with water molecules and is capable of hydrogen bonding. The quinolinecarboxylic acid moiety of 4-hydroxyquinoline-2-carboxylic acid hydrate has been shown to have neuroprotective effects against neurotoxicity induced by kynurenic acid, an endogenous compound. 4-Hydroxyquinoline-2-carboxylic acid hydrate has broad spectrum activity and can be used as a broad spectrum neuroprotective agent. The molecule also displays polymorphism with tautomeric behaviour and diffraction properties.

Fórmula: C₁₀H₇NO₃·H₂O

Pureza: Min. 95%

Peso molecular: 189.17 g/mol

Ref: 3D-VNA90935

Kynurenic Acid hydrate

CAS: 345909-35-5

Kynurenic acid, an active metabolite of tryptophan, is synthesized through a kynurenine intermediate by kynurenine aminotransferases (KATs). It acts as an antagonist of both NMDA and AMPA receptors, as well as α7 nicotinic acetylcholine receptors (nAChRs; EC50s = 235, 101, and 7 µM, respectively), and functions as an agonist for the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35; EC50s = 1.4 and 39 µM, respectively). In a neonatal rat model of cerebral hypoxic-ischemia, induced by carotid artery ligation, administration of kynurenic acid at 300 mg/kg prevents weight loss in the lesioned hemisphere. Additionally, at concentrations of 1 and 5 mg/ml, it protects against neurodegeneration in the rhabdomere of the eye in an Htt93QtransgenicDrosophila model of Huntington's disease. Elevated levels of kynurenic acid in the cerebrospinal fluid have been observed in patients with schizophrenia.

Fórmula: C₁₀H₉NO₄

Forma y color: Solid

Peso molecular: 207.185

Ref: TM-T84434