CAS 37558-16-0

forbol 12,13-dibutirato

Descripción:

forbol 12,13-dibutirato (PDBu) es un éster de fobol sintético derivado del compuesto natural fobol, que se obtiene de la resina de la planta Euphorbia. Se caracteriza por su capacidad para actuar como un potente promotor tumoral y un activador de la proteína quinasa C (PKC), lo que lo convierte en una herramienta valiosa en la investigación del cáncer y en estudios de señalización celular. PDBu es un compuesto lipofílico, lo que le permite penetrar fácilmente en las membranas celulares e interactuar con los objetivos celulares. Su estructura incluye dos grupos butirato esterificados al esqueleto de fobol, lo que mejora su actividad biológica en comparación con otros ésteres de fobol. PDBu se utiliza a menudo en entornos de laboratorio para inducir diferenciación en varios tipos de células y para estudiar los mecanismos de transducción de señales. Además, se ha demostrado que influye en varios procesos celulares, incluida la proliferación, la apoptosis y la expresión génica. Debido a sus potentes efectos biológicos, PDBu se maneja con cuidado en entornos de investigación, y su uso está sujeto a directrices regulatorias.

Fórmula: C₂₈H₄₀O₈

InChI: InChI=1/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3

Clave InChI: InChIKey=BQJRUJTZSGYBEZ-YVQNUNKESA-N

SMILES: O(C(CCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinónimos:

• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
• 12,13-Di-O-butyrylphorbol
• 4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
• 4β-Phorbol 12,13-dibutyrate
• 9aH-Cyclopropa[3,4]benz[1,2-e]azulene, butanoic acid deriv.
• Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester
• Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-
• Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-alpha))-
• Nsc 622507
• Phorbol dibutyrate
• Phorbol 12,13-dibutyrate
• Phorbol-12,13-dibutyrate
• C03634
• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester
• (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aα,7bα,9β,9aα-tetrol 9,9a-dibutyrate
• Phorbol 12,13-Dibutyrate >99%
• Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem
• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutyrate
• PHORBOL 12,13-DIBUTYRATE, 4BETA
• Phorbol 12,13-dibutanoate
• hyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diy
• butanoicacid,1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymet
• lester,(1ar-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-al
• (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5-oxo-5H-cyclopropa[3,4]benz[1,2-e]azulene-9β,9aα-diol 9,9a-dibutyrate
• 9β,9aα-Bis(butyryloxy)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

Phorbol 12,13-Dibutyrate

CAS: 37558-16-0

Fórmula: C₂₈H₄₀O₈

Pureza: 98%

Peso molecular: 504.6124

Ref: IN-DA00BXZ4

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Fórmula: C₂₈H₄₀O₈

Pureza: ≥ 98.0%

Forma y color: White to pale yellow or yellow solid

Peso molecular: 504.61

Ref: 7W-GL3377

Phorbol 12,13-Dibutyrate

CAS: 37558-16-0

Phorbol 12,13-Dibutyrate

Fórmula: C₂₈H₄₀O₈

Pureza: >99%

Forma y color: solid

Peso molecular: 504.61239g/mol

Ref: 54-BIP1016

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.

Fórmula: C₂₈H₄₀O₈

Pureza: 99.32% - 99.37%

Forma y color: Solid

Peso molecular: 504.61

Ref: TM-T16526

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Phorbol 12,13-dibutyrate is a potent inducer of protein kinase C (PKC) and is used as a tool to study PKC activity. It has been shown to induce the phosphorylation of certain proteins in human cells. This compound also induces the release of inflammatory mediators from polymorphonuclear leucocytes, which are white blood cells. Phorbol 12,13-dibutyrate is also used as a model system for studying the human papillary muscle and its biochemical properties. The effects of phorbol 12,13-dibutyrate on hl-60 cells have been studied extensively. This compound inhibits protein synthesis by preventing the binding of aminoacyl-tRNA to the ribosome and by inhibiting translocation of mRNA into the cytoplasm.

Fórmula: C₂₈H₄₀O₈

Pureza: Min. 95 Area-%

Forma y color: Powder

Peso molecular: 504.61 g/mol

Ref: 3D-MBA55816