CAS 38048-32-7

S-(4-Nitrobenzil)-6-tioinosina

Descripción:

S-(4-Nitrobenzil)-6-tioinosina es un compuesto químico que pertenece a la clase de análogos de nucleósidos, específicamente purinas modificadas. Presenta una estructura de tioinosina, donde el átomo de azufre reemplaza al oxígeno en el azúcar ribosa, mejorando su actividad biológica. La presencia del grupo 4-nitrobenzilo contribuye a sus propiedades únicas, influyendo potencialmente en su interacción con objetivos biológicos. Este compuesto se estudia a menudo por su papel en la investigación bioquímica, particularmente en el contexto del metabolismo de nucleósidos y sus posibles aplicaciones terapéuticas. Puede exhibir diversas actividades biológicas, incluidas propiedades antivirales o anticancerígenas, debido a sus modificaciones estructurales. El número CAS 38048-32-7 identifica de manera única esta sustancia en bases de datos químicas, facilitando su estudio y aplicación en la investigación científica. Al igual que muchos análogos de nucleósidos, su solubilidad, estabilidad y reactividad pueden variar, lo que hace esencial considerar estos factores en los diseños experimentales. En general, S-(4-Nitrobenzil)-6-tioinosina representa un compuesto significativo en el campo de la química medicinal y la bioquímica.

Fórmula: C₁₇H₁₇N₅O₆S

InChI: InChI=1/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1

Clave InChI: InChIKey=DYCJFJRCWPVDHY-LSCFUAHRSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(SCC4=CC=C(N(=O)=O)C=C4)N=CN3)O[C@H](CO)[C@H]1O

Sinónimos:

• 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
• 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
• S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine
• Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-
• S-(4-Nitrobenzyl)-6-thioinosine
• NSC 296962
• S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)
• 6-(p-nitrobenzylthio)inosine
• 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
• 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin
• 6-[(4-Nitrobenzyl)-mercapto]-inosine
• S-(p-Nitrobenzyl)-6-mercapto-9--D-ribofuranosylpurine
• 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine
• 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine
• S-(4-Nitrobenzyl)-6-thioinosine,99%
• 6-[[(4-Nitrophenyl)methyl]thio]-9-(β-D-ribofuranosyl)-9H-purine
• NBMPR, NBTI, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
• nitrobenzylthioinosine
• S-(P-NITROBENZYL)-6-THIOINOSINE
• S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA
• NBTI
• 4-Nitrobenzyl-6-mercaptoinosine
• (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
• S-(P-NITROBENZYL)-6-THIOINOSINE 98+%
• NBMPR

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

CAS: 38048-32-7

Fórmula: C₁₇H₁₇N₅O₆S

Pureza: 98%

Forma y color: Solid

Peso molecular: 419.4118

Ref: IN-DA003U66

Nitrobenzylthioinosine

CAS: 38048-32-7

Nitrobenzylthioinosine

Pureza: ≥98%

Peso molecular: 419.41g/mol

Ref: 54-BUP11914

6-[(4-Nitrobenzyl)Thio]-9-β-D-Ribofuranosylpurine

CAS: 38048-32-7

6-[(4-Nitrobenzyl)Thio]-9-β-D-Ribofuranosylpurine

Pureza: 98%

Peso molecular: 419.41g/mol

Ref: 54-OR1023078

S-(4-Nitrobenzyl)-6-thioinosine

CAS: 38048-32-7

Fórmula: C₁₇H₁₇N₅O₆S

Peso molecular: 419.41

Ref: 7W-GN6805

Nitrobenzylthioinosine

CAS: 38048-32-7

Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.

Fórmula: C₁₇H₁₇N₅O₆S

Pureza: 99.69% - 99.74%

Forma y color: Off-White Solid

Peso molecular: 419.41

Ref: TM-T8551

6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

CAS: 38048-32-7

Pureza: 98.0%

Peso molecular: 419.4100036621094

Ref: 10-F547423

S-(4-Nitrobenzyl)-6-thioinosine

CAS: 38048-32-7

S-(4-Nitrobenzyl)-6-thioinosine (SBT) is a nucleoside with biochemical properties that are similar to those of adenosine. SBT is an equilibrative nucleoside, which means that it can bind to both DNA and RNA. It has been shown to be effective in inhibiting the growth of cancer cells in vitro by binding to DNA. SBT binds to the purine nucleotide transporter and prevents the uptake of uridine, adenosine, and other nucleosides into the cell. This process leads to a decrease in intracellular concentrations of these nucleosides. SBT also binds to divalent metal ions such as copper or zinc, which may affect its activity on cancer cells.

Fórmula: C₁₇H₁₇N₅O₆S

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 419.41 g/mol

Ref: 3D-NN09410

S-(4-Nitrobenzyl)-6-thioinosine

Producto controlado

CAS: 38048-32-7

Applications S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
References (1) Zhu, Z., et al.: J. Med. Chem., 46, 831 (2003) (2) Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (2005) (3) Barnes, K., et al.: Circ. Res., 99, 510 (2006)

Fórmula: C₁₇H₁₇N₅O₆S

Forma y color: Neat

Peso molecular: 419.41

Ref: TR-N493695