CAS 38176-02-2

(+)-[3-ciano-3-(3,4-dimetoxifenil)hex-6-il](5,6-dimetoxifenetil)metilamonio cloruro

Descripción:

La sustancia química conocida como "(+)-[3-ciano-3-(3,4-dimetoxifenil)hex-6-il](5,6-dimetoxifenetil)metilamonio cloruro" con el número CAS 38176-02-2 es un compuesto de amonio cuaternario caracterizado por su estructura compleja, que incluye un grupo ciano, múltiples sustituyentes metoxi y una cadena hexílica. Este compuesto exhibe propiedades típicas de las sales de amonio cuaternario, como la solubilidad en disolventes polares y una posible actividad biológica. La presencia de grupos metoxi sugiere que puede tener una lipofilia mejorada, lo que puede influir en su interacción con las membranas biológicas. Además, el grupo ciano puede conferir características únicas de reactividad y estabilidad. Como sal de cloruro, es probable que sea iónico por naturaleza, lo que contribuye a su solubilidad en entornos acuosos. La estereoquímica específica indicada por la designación "(+)" sugiere que puede exhibir propiedades quirales, lo que puede afectar su perfil farmacológico e interacciones en sistemas biológicos. En general, las características estructurales únicas de este compuesto pueden hacerlo de interés en la química medicinal y la farmacología.

Fórmula: C₂₇H₃₈N₂O₄·ClH

InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m1./s1

Clave InChI: InChIKey=DOQPXTMNIUCOSY-HZPIKELBSA-N

SMILES: [C@](CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

Sinónimos:

• (+)-Verapamil hydrochloride
• (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride (1:1)
• (R)-Verapamil hydrochloride
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1), (αR)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (R)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (αR)-
• Dexverapamil monohydrochloride
• Lu 33925
• NSC 632821
• (+)-(3-Cyano-3-(3,4-dimethoxyphenyl)hex-6-yl)(5,6-dimethoxyphenethyl)methylammonium chloride
• R(+)-Verapamil hydrate monohydrochloride
• Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI)
• R(+)-Verapamil monohydrochloride
• (+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6-
• (αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride
• R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
• Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-
• R(+)-Verapamil monohydrochloride hydrate

(R)-Verapamil (hydrochloride)

CAS: 38176-02-2

(R)-Verapamil (hydrochloride)

Pureza: 98%

Peso molecular: 491.06g/mol

Ref: 54-OR1034236

R-Verapamil HCl

CAS: 38176-02-2

Fórmula: C₂₇H₃₈N₂O₄·HCl

Forma y color: White To Off-White Solid

Peso molecular: 454.61 36.46

Ref: 4Z-V-046

R-(+)-Verapamil monohydrochloride hydrate

CAS: 38176-02-2

Fórmula: C₂₇H₄₁ClN₂O₅

Peso molecular: 509.08

Ref: 7W-GP6309

(R)-(+)-Verapamil Hydrochloride

Producto controlado

CAS: 38176-02-2

Applications (R)-(+)-Verapamil Hydrochloride and both of its isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988); Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990);

Fórmula: C₂₇H₃₈N₂O₄·ClH

Forma y color: Neat

Peso molecular: 491.06

Ref: TR-V124990

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride

CAS: 38176-02-2

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.

Fórmula: C₂₇H₃₉ClN₂O₄

Pureza: Min. 95%

Peso molecular: 491.06 g/mol

Ref: 3D-ID28684

(R)-Verapamil hydrochloride

CAS: 38176-02-2

(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.

Fórmula: C₂₇H₃₉ClN₂O₄

Forma y color: Solid

Peso molecular: 491.06

Ref: TM-T12646