CAS 38213-69-3

Bis(maltolato)oxovanadio

Descripción:

Bis(maltolato)oxovanadio, con el número CAS 38213-69-3, es un compuesto de coordinación que presenta vanadio en su estado de oxidación +4, coordinado por dos ligandos maltolato. El maltolato se deriva del maltol, un compuesto conocido por su aroma y sabor dulce, y actúa como un ligando bidentado, coordinándose a través de los grupos hidroxilo y carbonilo. Este compuesto es notable por su potencial actividad biológica, particularmente en el contexto del manejo de la diabetes, ya que se ha estudiado por sus propiedades miméticas de la insulina. El centro de vanadio contribuye a su reactividad e interacciones biológicas. En términos de solubilidad, Bis(maltolato)oxovanadio es típicamente soluble en disolventes polares, lo que mejora su biodisponibilidad. La estructura del compuesto permite propiedades electrónicas interesantes, convirtiéndolo en un tema de investigación en química medicinal y ciencia de materiales. En general, Bis(maltolato)oxovanadio ejemplifica la intersección de la química inorgánica y la farmacología, mostrando cómo se pueden diseñar complejos metálicos para aplicaciones terapéuticas específicas.

Fórmula: C₁₂H₁₀O₇V

InChI: InChI=1/2C6H6O3.O.V/c2*1-4-6(8)5(7)2-3-9-4;;/h2*2-3,8H,1H3;;/q;;;+2/p-2/r2C6H6O3.OV/c2*1-4-6(8)5(7)2-3-9-4;1-2/h2*2-3,8H,1H3;/q;;+2/p-2

Clave InChI: InChIKey=XUOLEICXAPEOSI-UHFFFAOYSA-L

SMILES: O=[V+2]12([O-]C=3C(=O1)C=COC3C)[O-]C=4C(=O2)C=COC4C

Sinónimos:

• (SP-5-31)-Bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO⁴]oxovanadium
• 4H-Pyran-4-one, 3-hydroxy-2-methyl-, vanadium complex
• Bis(Maltolato) oxo vanadium
• Bis(Maltolato)Oxovanadium(Iv)
• Bis(maltolato)oxovanadium
• Vanadium, bis(3-hydroxy-2-methyl-4H-pyran-4-onato-O³,O⁴)oxo-, (SP-5-31)-
• Vanadium, bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO⁴]oxo-, (SP-5-31)-
• Vanadium, bis(3-hydroxy-2-methyl-4H-pyran-4-onato-O3,O4)oxo-, (SP-5-31)-
• (SP-5-31)-Bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO4]oxovanadium
• Vanadium, bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO4]oxo-, (SP-5-31)-
• BMOV

Bis(Maltolato)Oxovanadium(IV)

CAS: 38213-69-3

Bis(Maltolato)Oxovanadium(IV)

Pureza: 98%

Peso molecular: 317.15g/mol

Ref: 54-IN12059

Bis(maltolato)oxovanadium(IV)

CAS: 38213-69-3

Bis(maltolato)oxovanadium(IV)

Pureza: ≥98%

Peso molecular: 317.15g/mol

Ref: 54-BUP15475

Bis(maltolato)oxovanadium(IV)

CAS: 38213-69-3

BMOV: oral pan-PTP inhibitor, mimics insulin, anti-diabetic, improves heart function in diabetes, IC50s: 126-201 nM.

Fórmula: C₁₂H₁₀O₇V

Pureza: 99.65% - 99.918%

Forma y color: Solid

Peso molecular: 317.15

Ref: TM-T22276

Bis(maltolato)oxovanadium(IV)

Producto controlado

CAS: 38213-69-3

Applications It is a potent insulin mimic. Results showed that BMOV significantly decreased plasma glucose levels in diabetic rats at all given doses, and restored hyperglycemic values to normal value. BMOV has a promising outlook as an oral glucose-lowering drug.
References Cantley, L., et al.: J. Biol. Chem., 252, 7421 (1977), Shechter, Y., et al.: Diabetes, 39, 1 (1990), Cohen, N., et al.: J. Clin. Invest., 95, 2501 (1995), Reul, B., et al.: Br. J. Pharmacol., 126, 467 (1999), Yuen, V., et al.: Diabetes Res. Clin. Pract., 43, 9 (1999),

Fórmula: C₁₂H₁₀O₇V

Forma y color: Neat

Peso molecular: 317.15

Ref: TR-B478500

Bis(maltolato)oxovanadium(IV)

CAS: 38213-69-3

Bis(maltolato)oxovanadium(IV) is a vanadium compound that has an insulin-like effect on blood glucose levels. It binds to the IL-2 receptor, which is an essential protein in the immune system. The binding of Bis(maltolato)oxovanadium(IV) to IL-2 receptor increases the production of IL-2 and activates insulin-sensitive K+ channels, resulting in increased uptake of glucose from the blood. This leads to decreased serum glucose levels and improved glycemic control. Although not fully understood, it is thought that this anti-diabetic drug may act through its interaction with the IL-2 receptor to regulate insulin sensitivity and glucose transport. In addition, Bis(maltolato)oxovanadium(IV) has been shown to have a protective effect on myocardial infarction (heart attack), as well as protecting against iron deficiency by increasing iron homeostasis.

Fórmula: C₁₂H₁₀O₇V

Pureza: Min. 95%

Forma y color: Brown Powder

Peso molecular: 317.15 g/mol

Ref: 3D-FB18735