CAS 3862-25-7

7α-Hidroxi-4-colesten-3-ona

Descripción:

7α-Hidroxi-4-colesten-3-ona, con el número CAS 3862-25-7, es un compuesto esteroide que desempeña un papel significativo en el metabolismo del colesterol y es un intermediario clave en la biosíntesis de ácidos biliares. Este compuesto presenta un grupo hidroxilo en la posición 7α de la estructura de cholesteno, lo que contribuye a su actividad biológica. Se encuentra típicamente en varios sistemas biológicos, incluidos los tejidos humanos, donde participa en la regulación de los niveles de colesterol y puede influir en el metabolismo de lípidos. La presencia del grupo hidroxilo mejora su solubilidad en fluidos biológicos, facilitando su interacción con enzimas y receptores. Además, se sabe que 7α-Hidroxi-4-colesten-3-ona es un ligando para los receptores X hepáticos (LXRs), que son receptores nucleares que regulan genes involucrados en la homeostasis de lípidos. Sus características estructurales, incluidos el marco esteroide y los grupos funcionales, son cruciales para sus funciones biológicas y aplicaciones terapéuticas potenciales en el manejo de trastornos relacionados con el colesterol.

Fórmula: C₂₇H₄₄O₂

InChI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1

Clave InChI: InChIKey=IOIZWEJGGCZDOL-RQDYSCIWSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C[C@H]3O)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]

Sinónimos:

• (7Alpha,8Xi)-7-Hydroxycholest-4-En-3-One
• (7α)-7-Hydroxycholest-4-en-3-one
• 7α-Hydroxy-4-cholesten-3-one
• 7α-Hydroxycholest-4-en-3-one
• Cholest-4-En-3-One, 7-Hydroxy-, (7Alpha,8Xi)-
• Cholest-4-en-3-one, 7-hydroxy-, (7alpha)-
• Cholest-4-en-3-one, 7-hydroxy-, (7α)-
• Cholest-4-en-3-one, 7α-hydroxy-

(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

CAS: 3862-25-7

Fórmula: C₂₇H₄₄O₂

Pureza: %

Forma y color: Solid

Peso molecular: 400.6371

Ref: IN-DA00C9GN

Cholesterol Impurity 36

CAS: 3862-25-7

Fórmula: C₂₇H₄₄O₂

Peso molecular: 400.65

Ref: 4Z-C-5345

7α-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

7α-Hydroxy-4-cholesten-3-one

Pureza: ≥98%

Peso molecular: 400.64g/mol

Ref: 54-BUP00441

Cholesterol Impurity 36-d7

CAS: 3862-25-7

Fórmula: C₂₇H₃₇D₇O₂

Peso molecular: 407.69

Ref: 4Z-C-5346

7Alpha-Hydroxy-4-cholesten-3-one-d7 (contains 2% d0)

Producto controlado

CAS: 3862-25-7

Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),

Fórmula: C₂₇H₃₇D₇O₂

Forma y color: Neat

Peso molecular: 407.68

Ref: TR-H825133

7alpha-Hydroxy-4-cholesten-3-one-d7

Producto controlado

CAS: 3862-25-7

Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),

Fórmula: C₂₇H₃₇D₇O₂

Forma y color: White To Off-White

Peso molecular: 407.68

Ref: TR-H825132

7alpha-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),

Fórmula: C₂₇H₄₄O₂

Forma y color: Neat

Peso molecular: 400.64

Ref: TR-H825130

7α-Hydroxy-4-cholesten-3-one

Producto controlado

CAS: 3862-25-7

Intermediate in bile acids biosynthesis

Fórmula: C₂₇H₄₄O₂

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 400.64 g/mol

Ref: 3D-FH24257

7α-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

Fórmula: C₂₇H₄₄O₂

Peso molecular: 400.65

Ref: ST-EA-CP-C71043

7α-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

7α-Hydroxy-4-cholesten-3-one is a PXR agonist that can be used to study diseases associated with defects in bile acid biosynthesis.

Fórmula: C₂₇H₄₄O₂

Pureza: 99.14%

Forma y color: White Solid

Peso molecular: 400.64

Ref: TM-T10196

7-Hydroxy-4-cholesten-3-one-D7

Producto controlado

CAS: 3862-25-7

7-Hydroxy-4-cholesten-3-one-D7 (7OHCD7) is a metabolite of the bile acid, cholic acid. It is generated by the action of cholesterol 7α hydroxylase on cholesterol in the liver. It is excreted in bile, which is then absorbed back into the body from the gut and used for energy metabolism. 7OHCD7 has been shown to be an inhibitor of histone deacetylases, which are enzymes that regulate gene transcription. This inhibition leads to increased transcriptional regulation and reduced inflammatory responses in bowel disease models. 7OHCD7 has also been shown to increase cholesterol levels and reduce inflammation in humans with metabolic syndrome.

Fórmula: C₂₇H₄₄O₂

Pureza: Min. 95%

Peso molecular: 400.64 g/mol

Ref: 3D-FH58232