CAS 3862-25-7
:7α-Hidroxi-4-colesten-3-ona
Descripción:
7α-Hidroxi-4-colesten-3-ona, con el número CAS 3862-25-7, es un compuesto esteroide que desempeña un papel significativo en el metabolismo del colesterol y es un intermediario clave en la biosíntesis de ácidos biliares. Este compuesto presenta un grupo hidroxilo en la posición 7α de la estructura de cholesteno, lo que contribuye a su actividad biológica. Se encuentra típicamente en varios sistemas biológicos, incluidos los tejidos humanos, donde participa en la regulación de los niveles de colesterol y puede influir en el metabolismo de lípidos. La presencia del grupo hidroxilo mejora su solubilidad en fluidos biológicos, facilitando su interacción con enzimas y receptores. Además, se sabe que 7α-Hidroxi-4-colesten-3-ona es un ligando para los receptores X hepáticos (LXRs), que son receptores nucleares que regulan genes involucrados en la homeostasis de lípidos. Sus características estructurales, incluidos el marco esteroide y los grupos funcionales, son cruciales para sus funciones biológicas y aplicaciones terapéuticas potenciales en el manejo de trastornos relacionados con el colesterol.
Fórmula:C27H44O2
InChI:InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
Clave InChI:InChIKey=IOIZWEJGGCZDOL-RQDYSCIWSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C[C@H]3O)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]
Sinónimos:- (7Alpha,8Xi)-7-Hydroxycholest-4-En-3-One
- (7α)-7-Hydroxycholest-4-en-3-one
- 7α-Hydroxy-4-cholesten-3-one
- 7α-Hydroxycholest-4-en-3-one
- Cholest-4-En-3-One, 7-Hydroxy-, (7Alpha,8Xi)-
- Cholest-4-en-3-one, 7-hydroxy-, (7alpha)-
- Cholest-4-en-3-one, 7-hydroxy-, (7α)-
- Cholest-4-en-3-one, 7α-hydroxy-
Ordenar por
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Encontrado 11 productos.
(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS:Fórmula:C27H44O2Pureza:%Forma y color:SolidPeso molecular:400.63717α-Hydroxy-4-cholesten-3-one-d7 (contains 2% d0)
CAS:Producto controlado<p>Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>Fórmula:C27H37D7O2Forma y color:NeatPeso molecular:407.687α-Hydroxy-4-cholesten-3-one-d7
CAS:Producto controlado<p>Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),<br></p>Fórmula:C27H37D7O2Forma y color:White To Off-WhitePeso molecular:407.687α-Hydroxy-4-cholesten-3-one
CAS:<p>Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>Fórmula:C27H44O2Forma y color:NeatPeso molecular:400.647α-Hydroxy-4-cholesten-3-one
CAS:Producto controlado<p>Intermediate in bile acids biosynthesis</p>Fórmula:C27H44O2Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:400.64 g/mol7-Hydroxy-4-cholesten-3-one-D7
CAS:Producto controlado<p>7-Hydroxy-4-cholesten-3-one-D7 (7OHCD7) is a metabolite of the bile acid, cholic acid. It is generated by the action of cholesterol 7α hydroxylase on cholesterol in the liver. It is excreted in bile, which is then absorbed back into the body from the gut and used for energy metabolism. 7OHCD7 has been shown to be an inhibitor of histone deacetylases, which are enzymes that regulate gene transcription. This inhibition leads to increased transcriptional regulation and reduced inflammatory responses in bowel disease models. 7OHCD7 has also been shown to increase cholesterol levels and reduce inflammation in humans with metabolic syndrome.</p>Fórmula:C27H44O2Pureza:Min. 95%Peso molecular:400.64 g/mol7α-Hydroxy-4-cholesten-3-one
CAS:7α-Hydroxy-4-cholesten-3-one is a PXR agonist that can be used to study diseases associated with defects in bile acid biosynthesis.Fórmula:C27H44O2Pureza:99.14%Forma y color:White SolidPeso molecular:400.64
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