CAS 38819-10-2

2-amino-9-(beta-D-arabinofuranosil)-3,9-dihidro-6H-purina-6-ona

Descripción:

2-amino-9-(beta-D-arabinofuranosil)-3,9-dihidro-6H-purina-6-ona, comúnmente conocido como Ara-A o arabinosiladenina, es un análogo de nucleósido con notables propiedades antivirales. Se caracteriza por su estructura de base purínica, que incluye un grupo amino en la posición 2 y un moiety de azúcar beta-D-arabinofuranosilo. Este compuesto exhibe una estereoquímica única que contribuye a su actividad biológica, particularmente en la inhibición de la replicación viral. Ara-A se utiliza principalmente en el tratamiento de infecciones virales, incluidas las causadas por el virus del herpes simple y otros virus de ARN. Su mecanismo de acción implica la interferencia con la síntesis de ácidos nucleicos virales, lo que lo convierte en un agente terapéutico valioso. El compuesto se administra típicamente en su forma de fosfato para mejorar la solubilidad y la biodisponibilidad. Además, se ha estudiado Ara-A por su potencial en la terapia del cáncer debido a su capacidad para interrumpir procesos celulares. En general, sus características estructurales y actividades biológicas lo convierten en un compuesto significativo en la química medicinal y la virología.

Fórmula: C₁₀H₁₃N₅O₅

InChI: InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1

Clave InChI: InChIKey=NYHBQMYGNKIUIF-FJFJXFQQSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)NC(N)=N1

Sinónimos:

• 1-β-D-Arabinofuranosylguanine
• 2-Amino-6-hydroxy-9-(β-<span class="text-smallcaps">D</span>-arabinofuranosyl)purine
• 2-Amino-9-(beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one
• 2-Amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-1,9-dihydro-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-1,9-dihydro-
• 6H-purin-6-one, 2-amino-9-beta-D-arabinofuranosyl-1,9-dihydro-
• 9-(Beta-D-Arabinofuranosyl)Guanine
• 9-Arabinoguanine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosylguanine
• A 4233
• Arabinoguanosine
• Araguanosine
• Guanine arabinoside
• Guanine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• NSC 76352
• ara-Guanosine
• Arabinosylguanine
• 9-β-D-Arabinofuranosylguanine
• Guanine, 9-β-D-arabinofuranosyl-
• 2-Amino-6-hydroxy-9-(β-D-arabinofuranosyl)purine
• 6H-Purin-6-one, 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro-
• 2-Amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one
• )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-16-methyl-d3-pregna-1,4-diene-3,20-dione
• )-10-Bromo-8,9,10,11-tetrahydrobenz[a]anthracene-8,9,11-triol
• 9-beta-D-Arabinofuranosylguanine Hydrate
• GUANINE-9-ARABINOSIDE
• -Epoxy-21dehydroxy Betamethasone
• Ara-G
• 9-β-D-Arabinofuranosyl-1,6-dihydro-2-amino-6-oxo-9H-purine
• 9-beta-Arabinosylguanine
• )-9,11-Epoxy-pregna-1,4,16-triene-3,20-dione
• 9-(β-D-Arabinoribofuranosyl)-guanine
• 9-arabinofuranosylguanine
• 9-(BETA-D-ARABINOFURANOSYL)GUANINE USP/EP/BP
• 9-(b-D-Arabinofuranosyl)guanine
• 9-β-D-Arabinofuranosyl-2-amino-9H-purin-6-ol
• )-9,11-Epoxy-6-fluoro-21-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• 9-β-D-Arabinofuranosylguanine Hydrate
• 2-AMino-9-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
• )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• -Epoxy-17,21-dihydroxy-16&beta
• 2-amino-9-beta-d-arabinofuranosyl-1,9-dihydro-6h-purin-6-on
• Guanine, 9-(beta-D-arabinofuranosyl)-
• 9-β-D-Arabinofuranosylguanine Hydrate &gt
• 9-&beta
• 9-(beta-d-arabinofuranosyl)-guanin
• )-9,11-Epoxy-1,21-dihydroxy-4,16-dimethyl-19-norpregna-1,3,5(10)-trien-20-one
• 9-(β-D-Arabinofuranosyl)guanine ,97%
• )-9,11-Epoxy-21-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• )-21-(Acetyloxy)-9,11-epoxypregna-1,4,16-triene-3,20-dione
• 2-Amino-9-β-D-arabinofuranosyl-9H-purine-6(1H)-one
• Ara-G hydrate, 98%, inhibitor of DNA synthesis, an antimetabolite and antineoplastic.
• Ara-G hydrate
• -Arabinofuranosylguanine Hydrate
• 2-amino-9-(beta-D-arabinofuranosyl)-3,9-dihydro-6H-purin-6-one
• ARABINOFURANOSYL-GUANINE
• D
• -
• )-9-Bromo-8,9,10,11-tetrahydrobenz[a]anthracene-8,10,11-triol-d9
• Arabinofuranosyl-guanine (ara-G)
• )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-pregna-1,4,16-triene-3,20-dione
• 9-β-D-Arabinofuranosyl guanine hydrate
• -methyl-pregn-4-ene-3,20-dione
• )-9,11-Epoxy-6-fluoropregna-1,4,16-triene-3,20-dione
• ARA-G 9-(BETA-D-ARABINOFURANOSYL)-GUANINE

9-β-D-Arabinofuranosylguanine

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 283.2407

Ref: IN-DA0037XI

9-β-Arabinosylguanine

CAS: 38819-10-2

9-β-Arabinosylguanine

Pureza: 98%

Peso molecular: 283.24g/mol

Ref: 54-OR1026312

Ara-G

CAS: 38819-10-2

Ara-G

Pureza: ≥98%

Peso molecular: 283.24g/mol

Ref: 54-BUP16058

9-β-D-Arabinofuranosylguanine

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 283.24

Ref: 3B-A2739

9-(b-D-Arabinofuranosyl)guanine

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅·xH₂O

Pureza: ≥ 97.5%

Forma y color: White to off-white crystalline powder

Peso molecular: 283.24 (anhydrous)

Ref: 7W-GN2070

Nelarabine Impurity 16

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅

Peso molecular: 283.24

Ref: 4Z-N-5217

Ara-G

CAS: 38819-10-2

Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.

Fórmula: C₁₀H₁₃N₅O₅

Pureza: 98.74%

Forma y color: Slightly Off White To White Powder

Peso molecular: 283.24

Ref: TM-T36944

9-(b-D-Arabinofuranosyl)guanine - Bio-X ™

CAS: 38819-10-2

9-(b-D-Arabinofuranosyl) guanine is a purine nucleoside in which guanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. 9-(b-D-Arabinofuranosyl) guanine binds to the phosphate groups in DNA and inhibits the synthesis of DNA causing cell death. It also has antineoplastic properties.

Fórmula: C₁₀H₁₃N₅O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 283.24 g/mol

Ref: 3D-BA300152

9-(b-D-Arabinofuranosyl)guanine

CAS: 38819-10-2

9-(b-D-Arabinofuranosyl)guanine is an arabinoside derivative that has high affinity for DNA. 9-(b-D-Arabinofuranosyl)guanine binds to the phosphate groups in DNA and inhibits the synthesis of DNA. It is used in vitro assays to study molecular pathogenesis and in vivo as a drug against leukemia, lymphomas, and other cancers. 9-(b-D-Arabinofuranosyl)guanine also inhibits protein synthesis by binding to ribosomes. This drug can cause significant side effects such as gastrointestinal distress, diarrhea, nausea, vomiting, and abdominal pain. It can also cause blood dyscrasias and liver damage.

Fórmula: C₁₀H₁₃N₅O₅

Pureza: Min. 97 Area-%

Forma y color: White Powder

Peso molecular: 283.24 g/mol

Ref: 3D-NA06002

9-β-D-ARABINOFURANOSYLGUANINE

CAS: 38819-10-2

Pureza: 98%

Peso molecular: 283.243988

Ref: 10-F858517

9-b-D-Arabinofuranosylguanine

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅

Pureza: 95.0%

Forma y color: Liquid, No data available.

Peso molecular: 283.244

Ref: 10-F225628

Ara-G-13C,15N2

Producto controlado

CAS: 38819-10-2

Fórmula: CC₉H₁₃₁₅N₂N₃O₅

Forma y color: Neat

Peso molecular: 286.22

Ref: TR-A765559

Ara-G

Producto controlado

CAS: 38819-10-2

Applications Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic.

Fórmula: C₁₀H₁₃N₅O₅

Forma y color: Off-White

Peso molecular: 283.24

Ref: TR-A765558

Nelarabine Impurity 16

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅

Peso molecular: 283.24

Ref: ST-EA-CP-N38018

9-(b-D-Arabinofuranosyl)guanine

CAS: 38819-10-2

Fórmula: C₁₀H₁₃N₅O₅

Peso molecular: 283.24

Ref: ST-EA-CP-A88013