CAS 4004-05-1

1,2-Dioleoil-sn-glicero-3-fosfoetanolamina

Descripción:

1,2-Dioleoil-sn-glicero-3-fosfoetanolamina (DOPE) es un fosfolípido comúnmente utilizado en bioquímica y biología molecular. Se caracteriza por sus cadenas de ácidos grasos oleoyl duales, que contribuyen a su naturaleza anfipática, permitiéndole formar bicapas lipídicas y vesículas en entornos acuosos. La molécula consiste en un esqueleto de glicerol, dos cadenas oleoyl y un grupo cabeza de fosfoetanolamina, que le confiere una carga neta neutra a pH fisiológico. Se conoce que DOPE facilita la fusión de membranas y se utiliza a menudo en sistemas de entrega de fármacos, particularmente para la encapsulación de ácidos nucleicos y proteínas. Su fluidez y capacidad para adoptar varias conformaciones lo convierten en un componente valioso en formulaciones liposomales. Además, DOPE puede mejorar la estabilidad y eficacia de vacunas y terapias génicas. La sustancia se almacena típicamente en condiciones controladas para mantener su integridad y es soluble en disolventes orgánicos, lo que la hace adecuada para diversas aplicaciones de laboratorio.

Fórmula: C₄₁H₇₈NO₈P

InChI: InChI=1/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

Clave InChI: InChIKey=MWRBNPKJOOWZPW-NYVOMTAGSA-N

SMILES: [C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCN)(=O)O

Sinónimos:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-[(9Z)-octadec-9-enoyloxy]propyl (9Z)-octadec-9-enoate
• 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphorylethanolamine
• 9-Octadecenoic acid (9Z)-, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 9-Octadecenoic acid (9Z)-, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• 9-Octadecenoic acid (Z)-, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• <span class="text-smallcaps">L</span>-α-Dioleoylphosphatidylethanolamine
• Coatsome MC 8181
• Coatsome ME 8181
• Dioleoyl phosphoethanolamine
• Dioleoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• Dioleoylphosphatidylethanolamine
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, <span class="text-smallcaps">L</span>-
• L-A-phosphatidylethanolamine dioleoyl
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, L-
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, L-
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, >99%
• (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-ETHA-N OLAMINE, 10 MG/ML
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)
• 1,2-Dioleoyl-sn-glycero-3-PE
• sn
• PE(18:1(9Z)/18:1(9Z))
• 18:1 PE
• 3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL
• O-(1-O,2-O-Dioleoyl-L-glycero-3-phospho)-2-aminoethanol
• 18:1 (Delta9-Cis) PE (DOPE)
• 2-Aminoethyl (R)-2,3-bis(oleoyloxy)propyl hydrogen phosphate
• 1,2-Dioleoyl-
• dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)
• 1,2-Dioleoyl-3-sn-phosphatidylethanolamine
• L-β,γ-Dioleoyl-α-cephalin
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9)
• DOPE
• L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN
• (+)-1-O,2-O-Dioleoyl-L-glycerol 3-(phosphoric acid 2-aminoethyl) ester
• Phosphoric acid hydrogen (2-aminoethyl)[(2R)-2,3-bis(oleoyloxy)propyl] ester
• L-A-PHOSPHATIDYLETHANOLAMINE, DIOLEO
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine≥ 98% (HPTLC)
• DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 98+%
• 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE
• COATSOME ME-8181 (DOPE)
• -glycero-3-phosphoethanolamine

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

Fórmula: C₄₁H₇₈NO₈P

Pureza: >98.0%(T)

Forma y color: White to Light yellow powder to lump

Peso molecular: 744.05

Ref: 3B-D4251

9-Octadecenoic acid (9Z)-,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediylester

CAS: 4004-05-1

Fórmula: C₄₁H₇₈NO₈P

Pureza: 98%

Forma y color: Solid

Peso molecular: 744.0337

Ref: IN-DA00IMFR

DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

Pureza: ≥95%

Peso molecular: 744.03g/mol

Ref: 54-BUP17310

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

CAS: 4004-05-1

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

Fórmula: C₄₁H₇₈NO₈P

Pureza: 98%

Peso molecular: 744.03g/mol

Ref: 54-BI12158

1,2-Dioleoyl-d62-sn-glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Fórmula: C41H16D62NO8P

Pureza: >98%

Forma y color: Solid

Peso molecular: 806.43

Ref: 48-71-5718

1,2-Dioleoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Fórmula: C41H78NO8P

Pureza: >98%

Forma y color: Solid

Peso molecular: 744.04

Ref: 48-37-1821

DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)

CAS: 4004-05-1

Fórmula: C₄₁H₇₈NO₈P

Peso molecular: 744.05

Ref: 4Z-F-106056

DOPE

CAS: 4004-05-1

DOPE, a neutral lipid, boosts cationic liposome efficiency in non-viral gene delivery.

Fórmula: C₄₁H₇₈NO₈P

Pureza: 97.23% - ≥98%

Forma y color: Lyophilized Powder

Peso molecular: 744.03

Ref: TM-T19080

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

Fórmula: C₄₁H₇₈NO₈P

Pureza: 98%

Forma y color: light yellow waxy solid

Peso molecular: 744.03368g/mol

Ref: 54-OR54392

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)

Producto controlado

CAS: 4004-05-1

Applications 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
References Misra, S.K., et al.: PLoS One, 8, e68305 (2013); MacDonald, R., et al.: J. Pharm. Sci., 88, 896 (1999); Chen, Y., et al.: Int. J. Nanomedicine, 8, 1573 (2013)

Fórmula: C₄₁H₇₈NO₈P

Forma y color: Neat

Peso molecular: 744.034

Ref: TR-D482210

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a synthetic lipid that has been extensively studied for its ability to form liposomes and other lipid bilayers. DOPE is used as a model system for studying the phase transition temperature of phospholipid membranes. DOPE has also been shown to be effective in the transfection of cells with plasmids and other DNA molecules. DOPE is cationic, which allows it to interact with anionic membrane proteins and facilitate their insertion into the membrane. This facilitates the formation of multilamellar vesicles, which are necessary for vesicle budding and fusion.

Fórmula: C₄₁H₇₈NO₈P

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 744.03 g/mol

Ref: 3D-FD148481

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

M01678 - 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Fórmula: C₄₁H₇₈NO₈P

Pureza: 97%

Forma y color: Solid

Peso molecular: 744.048

Ref: 10-M01678

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4

Producto controlado

CAS: 4004-05-1

Fórmula: C₄₁D₄H₇₄NO₈P

Forma y color: Neat

Peso molecular: 748.058

Ref: TR-D482212