CAS 402824-96-8

6-cloro-4-[[(6-cloro-1,1-dioxo-3,4-dihidro-2H-benzo[e][1,2,4]tiazina-7-il)sulfonilamino]metil]-1,1-dioxo-2,3-dihidrobenzo[e][1,2,4]tiazina-7-sulfonamida

Descripción:

6-cloro-4-[[(6-cloro-1,1-dioxo-3,4-dihidro-2H-benzo[e][1,2,4]tiazina-7-il)sulfonilamino]metil]-1,1-dioxo-2,3-dihidrobenzo[e][1,2,4]tiazina-7-sulfonamida, con número CAS 402824-96-8, es un compuesto orgánico complejo caracterizado por su estructura de múltiples anillos y la presencia de grupos funcionales sulfonamida y dioxo. Este compuesto presenta un sustituyente cloro, que contribuye a su reactividad y potencial actividad biológica. La presencia de anillos de tiadiazina sugiere aplicaciones potenciales en química medicinal, particularmente en el desarrollo de fármacos. Se conoce que el grupo sulfonamida tiene propiedades antibacterianas, lo que indica que este compuesto puede exhibir actividades biológicas similares. Su estructura intrincada también puede influir en su solubilidad, estabilidad e interacción con objetivos biológicos. En general, este compuesto representa una clase de compuestos heterocíclicos que pueden tener implicaciones significativas en el descubrimiento y desarrollo de medicamentos, particularmente en la orientación a enzimas o receptores específicos en diversas áreas terapéuticas. Se necesitarían más estudios para elucidar su comportamiento químico completo y aplicaciones potenciales.

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

InChI: InChI=1/C15H16Cl2N6O8S4/c16-8-1-10-14(34(28,29)20-5-19-10)4-13(8)33(26,27)21-6-23-7-22-35(30,31)15-3-12(32(18,24)25)9(17)2-11(15)23/h1-4,19-22H,5-7H2,(H2,18,24,25)

SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)NCN1CNS(=O)(=O)c2cc(c(cc12)Cl)S(=O)(=O)N)Cl

Sinónimos:

• Hydrochlorothiazide EP Impurity C (Hydrochlorothiazide Dimer)
• Hydrochlorothiazide EP impurity C/ Dimer
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode
• 6
• ,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
• Hydrochlorothiazide Impurity C
• 6-chloro-4-((6-chloro-1,1-dioxido-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamido)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
• Hydrochlorothiazide IMpurity-C(EP)
• Hydrochlorothiazide Dimer
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ
• HCTZ-CH2-HCTZ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide\nHydrochlorothiazide Impurity C:
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamid
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, N-[[7-(aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-, 1,1-dioxide
• 6-Chloro-N-[(6-chloro-7-sulfamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• ,2,4-benzothiadiazine-7-sulfonamide

Hydrochlorothiazide Dimer (6-Chloro-4-({[(6-chloro-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl)sulfonyl]amino}methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide)

CAS: 402824-96-8

Sulfonamides, nesoi

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Forma y color: White Solid

Peso molecular: 605.92895

Ref: 45-1A15670

N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode

CAS: 402824-96-8

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Pureza: 95%

Forma y color: Solid

Peso molecular: 607.4889

Ref: IN-DA00C9HM

Hydrochlorothiazide EP Impurity C

CAS: 402824-96-8

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Forma y color: White To Off-White Solid

Peso molecular: 607.47

Ref: 4Z-H-054

HCTZ-CH2-HCTZ

CAS: 402824-96-8

HCTZ-CH2-HCTZ

Pureza: 98%

Ref: 54-OR1037135

Hydrochlorothiazide Impurity C

CAS: 402824-96-8

Impurity C in hydrochlorothiazide, a thiazide diuretic blocking NaCl cotransporter in kidneys.

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Forma y color: Solid

Peso molecular: 607.49

Ref: TM-T35728

6-Chloro-N-[(6-chloro-7-sulphamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-Dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothia-diazine-7-sulphonamide 1,1-Dioxide

CAS: 402824-96-8

Forma y color: Neat

Ref: 86-MM0011.04

Hydrochlorothiazide Dimer

CAS: 402824-96-8

Impurity Hydrochlorothiazide EP Impurity C
Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.
References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Forma y color: Off-White

Peso molecular: 607.49

Ref: TR-A629375

Hydrochlorothiazide EP impurity C

CAS: 402824-96-8

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Peso molecular: 607.47

Ref: ST-EA-CP-H3003

Hydrochlorothiazide impurity C

CAS: 402824-96-8

Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 607.49 g/mol

Ref: 3D-IA17850