CAS 40505-27-9
:4′-Desmetilpodofilotoxina
Descripción:
4′-Desmetilpodofilotoxina es un compuesto químico derivado de la especie vegetal Podophyllum peltatum, comúnmente conocido como el mayapple. Se clasifica como un lignano, que es un tipo de compuesto polifenólico. Esta sustancia se caracteriza por sus características estructurales, incluyendo un esqueleto de dibenzilbutirolactona, que contribuye a su actividad biológica. 4′-Desmetilpodofilotoxina exhibe propiedades antitumorales y se ha estudiado por su posible uso en la terapia del cáncer, particularmente debido a su capacidad para inhibir la división celular al interferir con el huso mitótico. El compuesto también es conocido por su papel como precursor en la síntesis de otros derivados farmacológicamente activos. En términos de solubilidad, generalmente es más soluble en disolventes orgánicos que en agua, lo que puede influir en su biodisponibilidad y aplicaciones terapéuticas. Al igual que muchos productos naturales, los procesos de extracción y purificación pueden afectar su rendimiento y potencia, lo que lo convierte en un área de interés para futuras investigaciones en química medicinal y farmacología.
Fórmula:C21H20O8
InChI:InChI=1/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19-/m0/s1
Clave InChI:InChIKey=YVCVYCSAAZQOJI-BTINSWFASA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H]
Sinónimos:- (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5R,5aR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- 4′-O-Demethylpodophyllotoxin
- 9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-(5α,5aβ,8aα,9α)]-
- Podophyllotoxin, 4′-demethyl-
- 4′-Demethylpodophyllotoxin
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
- (5R,5AR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
- 4'-Demethylpodophyllotoxin USP/EP/BP
- (5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-9β-hydroxy-5,5aα,6,8,8aβ,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one
- (5R)-5,8,8aβ,9-Tetrahydro-5β-(3,5-dimethoxy-4-hydroxyphenyl)-9β-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one
- 5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one
- (5R)-5,8,8aβ,9-Tetrahydro-9β-hydroxy-5β-(3,5-dimethoxy-4-hydroxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one
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Encontrado 10 productos.
(5R,5aR,8aR,9R)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
CAS:Pureza:97.0%Peso molecular:400.382995605468754'-Demethylpodophyllotoxin
CAS:4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.Fórmula:C21H20O8Pureza:99.27% - 99.60%Forma y color:SolidPeso molecular:400.384'-Demethylpodophyllotoxin
CAS:<p>4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies.</p>Fórmula:C21H20O8Pureza:Min. 95%Forma y color:PowderPeso molecular:400.38 g/mol4’-Demethylpodophyllotoxin
CAS:Producto controlado<p>Applications 4’-Demethylpodophyllotoxin is a lignan studied for its content in different parts of Sinopodophyllum hexandrum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y-L., et al.: Zhongguo Zhongyao Zazhi, 40, 1837-1841 (2015)<br></p>Fórmula:C21H20O8Forma y color:NeatPeso molecular:400.38
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