CAS 4146-30-9

Sulfato de neomicina B

Descripción:

Sulfato de neomicina B es un antibiótico aminoglucósido derivado de la bacteria *Streptomyces fradiae*. Se utiliza principalmente por sus propiedades antibacterianas, particularmente contra bacterias Gram-negativas. La sustancia se caracteriza por su estructura compleja, que incluye múltiples azúcares amino vinculados a un anillo de aminociclitol central. Sulfato de neomicina B es altamente soluble en agua, lo que lo hace adecuado para diversas formulaciones farmacéuticas, incluidas aplicaciones tópicas y oftálmicas. Presenta un amplio espectro de actividad, siendo particularmente efectivo contra infecciones causadas por *Escherichia coli* y *Klebsiella pneumoniae*. Sin embargo, su uso a menudo está limitado debido a la posible nefrotoxicidad y ototoxicidad, especialmente con la administración sistémica. Sulfato de neomicina B también se utiliza en entornos de laboratorio para la inhibición selectiva del crecimiento bacteriano. Su mecanismo de acción implica la unión al ribosoma bacteriano, interrumpiendo la síntesis de proteínas, lo que finalmente conduce a la muerte celular. Al igual que con todos los antibióticos, el uso apropiado es crucial para mitigar el riesgo de desarrollar resistencia a los antibióticos.

Fórmula: C₂₃H₄₆N₆O₁₃·3H₂O₄S

InChI: InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

Clave InChI: InChIKey=OIXVKQDWLFHVGR-WQDIDPJDSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N

Sinónimos:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-D-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3) (salt)
• Neomycin B sulfate
• Neomycin B trisulfate
• Neomycin B, sulfate (1:3) (salt)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3) (salt)

FRAMYCETIN SULFATE CRS

CAS: 4146-30-9

FRAMYCETIN SULFATE CRS

Fórmula: C₂₃H₄₈N₆O₁₇S

Peso molecular: 712.7222

Ref: 41-F0450000

FRAMYCETIN SULFATE (NEOMYCIN B SULFATE) RS

CAS: 4146-30-9

FRAMYCETIN SULFATE (NEOMYCIN B SULFATE) RS

Ref: 41-ICRS0355

D-STREPTAMINE, O-2,6-DIAMINO-2,6-DIDEOXY-β-L-IDOPYRANOSYL-(1->3)-O-β-D-RIBOFURANOSYL-(1->5)-O-[2,6-DIAMINO-2,6-DIDEOXY-A-D-GLUCOPYRANOSYL-(1->4)]-2-DEOXY-, SULFATE (1:3)

CAS: 4146-30-9

Fórmula: C₂₃H₅₂N₆O₂₅S₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 908.8792

Ref: IN-DA00BZ3H

Framycetin sulfate

CAS: 4146-30-9

Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.

Fórmula: C₂₃H₅₂N₆O₂₅S₃

Pureza: 99.79% - 99.89%

Forma y color: White To Yellowish Powder

Peso molecular: 908.86

Ref: TM-T2096

Framycetin sulfate, BP, Ph. Eur. grade

CAS: 4146-30-9

Fórmula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O

Pureza: ≤ 3.0%

Forma y color: White or pale yellow crystalline powder

Peso molecular: 712.72 (anhydrous)

Ref: 7W-GA7318

Framycetin sulfate

CAS: 4146-30-9

Framycetin sulfate

Pureza: ≥98%

Peso molecular: 712.22g/mol

Ref: 54-BUP17823

Neomycin B Trisulfate (Framycetin Trisulfate)

CAS: 4146-30-9

Fórmula: C₂₃H₄₆N₆O₁₃·3H₂SO₄

Forma y color: Off-White Solid

Peso molecular: 614.65 3*98.08

Ref: 4Z-N-080009

Framycetin sulfate

CAS: 4146-30-9

Fórmula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O

Pureza: ≥ 600IU/mg (dried basis)

Forma y color: White to pale yellow powder

Peso molecular: 712.72 (anhydrous)

Ref: 7W-GA3510

Neomycin B Trisulfate

CAS: 4146-30-9

Fórmula: C₂₃H₄₆N₆O₁₃(H₂SO₄)

Peso molecular: 614.65 : 3(98.07)

Ref: ST-EA-CP-N53013

Framycetin sulphate

CAS: 119-04-0, 28002-70-2, 4146-30-9

Framycetin sulphate is a broad-spectrum antibiotic that is used to treat microbial infections. It has been shown to be effective against many gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus. Framycetin sulphate prevents bacterial growth by inhibiting protein synthesis through binding to the 30S ribosomal subunit. This binding inhibits the incorporation of amino acids into proteins, thereby preventing the production of new proteins required for cell division and growth. Framycetin sulphate also has preservative properties, which may be due to its ability to chelate metal ions such as copper and iron. Framycetin sulphate can be administered orally or topically in vivo model studies. The drug was not found to have any significant toxic effects on the liver or kidneys in vivo model studies at concentrations up to 40%.

Fórmula: C₂₃H₅₂N₆O₂₅S₃

Pureza: Min. 95%

Peso molecular: 908.88 g/mol

Ref: 3D-FF150536