CAS 42228-92-2

Acivicina

Descripción:

Acivicina es un compuesto químico clasificado como un potente inhibidor de la enzima glutamina sintetasa, que juega un papel crucial en el metabolismo del nitrógeno. Es un análogo de aminoácido que se encuentra de forma natural y se deriva de fuentes microbianas. Acivicina exhibe una estructura única que le permite imitar la glutamina, interfiriendo así con sus funciones metabólicas normales. Esta inhibición puede llevar a efectos significativos en los procesos celulares, lo que hace que Acivicina sea de interés en la investigación del cáncer y en aplicaciones terapéuticas potenciales. El compuesto ha sido estudiado por su capacidad para inducir apoptosis en ciertas líneas celulares cancerosas, destacando su potencial como agente anticancerígeno. Además, Acivicina ha mostrado promesas en la modulación de respuestas inmunitarias, ampliando aún más sus aplicaciones potenciales en medicina. Sin embargo, su uso está limitado por la toxicidad y los efectos secundarios, lo que requiere una cuidadosa consideración en contextos terapéuticos. En general, Acivicina representa una herramienta valiosa en la investigación bioquímica y el desarrollo de fármacos, particularmente en los campos de la oncología y la inmunología.

Fórmula: C₅H₇ClN₂O₃

InChI: InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1

Clave InChI: InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N

SMILES: [C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H]

Sinónimos:

• (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]ethanoic acid
• (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic acid
• (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• (alphaS,5S)-alpha-Amino-3-chlor-4,5-dihydro-5-isoxazolylessigsaeure
• (alphaS,5S)-alpha-Amino-3-chloro-2-isoxazoline-5-acetic acid
• (α-S, 5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• 5-Isoxazoleacetic acid, 4,5-dihydro-alpha-amino-3-chloro-, (S-(R*,R*))-
• 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-
• 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-, (S-(R*,R*))-
• 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, (αS,5S)-
• 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, [S-(R*,R*)]-
• Acivicin [USAN:INN]
• Acivicine
• Acivicine [INN-French]
• Acivicino
• Acivicino [INN-Spanish]
• Acivicinum
• Acivicinum [INN-Latin]
• Amino(3-Chloro-4,5-Dihydro-1,2-Oxazol-5-Yl)Acetic Acid
• Antibiotic AT 125
• At 125
• Brn 1074648
• Nsc 163501
• U 42126
• Unii-O0X60K76I6
• Acivicin
• ALPHA-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID
• (s-(r*,r*))-4,5-dihydro-alpha-amino-3-chloro-5-isoxazoleaceticacid
• (alpha-s,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleaceticacid
• (5S,αS)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• antibioticat125
• AMINO-3-CHLORO-4,5-DIHYDROXY-5-ISOXAZOLEACETICACID
• (αS,5S)-
• Antibiotic U-42126
• (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid
• DIHYDROXY-5-ISOXAZOLEACETICACID
• 4,5-dihydro-alpha-amino-3-chloro-,(s-(r*,r*))-5-isoxazoleaceticaci
• AcivicinAcivicin

Acivicin, 98+%

CAS: 42228-92-2

Inhibits glutamine amidotransferases in purine and pyrimidine synthetic pathways. Tumor growth inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa A

Fórmula: C₅H₇ClN₂O₃

Pureza: 98+%

Forma y color: White to off-white, Powder

Peso molecular: 178.57

Ref: 02-J63105

ACIVICIN

CAS: 42228-92-2

Fórmula: C₅H₇ClN₂O₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 178.5737

Ref: IN-DA00C0CN

Acivicin

CAS: 42228-92-2

Acivicin

Pureza: 98%

Ref: 54-OR1037128

Acivicin

CAS: 42228-92-2

Acivicin (AT-125) is a chlorinated amino acid antibiotic produced by Streptomyces porcineus, a GGT inhibitor with anticancer and antiparasitic activity.

Fórmula: C₅H₇ClN₂O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 178.57

Ref: TM-T14114

Acivicin

Producto controlado

CAS: 42228-92-2

Applications Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase (GGT). Acivicin is a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells.
References Hanigan, M., et al.: Biochemistry, 32, 6302 (1993); Suzuki, H., et al.: J. Bacteriol., 175, 6038 (1993); Suzuki, H., et al.: J. Biol. Chem., 277, 43536 (2002); Magdalena, L., et al.: Biochem. Pharma., 77, 76 (2009)

Fórmula: C₅H₇ClN₂O₃

Forma y color: Off White Solid

Peso molecular: 178.57

Ref: TR-A190150

Acivicin

CAS: 42228-92-2

Pureza: 98%

Peso molecular: 178.5700073

Ref: 10-F791463

(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid

CAS: 42228-92-2

(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid is an inhibitor of the enzyme glutathione reductase (GR) and cytochrome P450. GR activates glutathione in cells to form a powerful antioxidant that protects against oxidative stress. (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid inhibits GR and cytochrome P450 activity, leading to increased oxidative stress and neuronal death. This drug has been shown to have inhibitory properties on bowel disease by reducing the production of proinflammatory cytokines IL1β and TNFα. The compound also exhibits anti tumor response against mouse tumors by inducing apoptosis and inhibiting cell proliferation. The compound targets intracellular targets

Fórmula: C₅H₇ClN₂O₃

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 178.57 g/mol

Ref: 3D-FA17203