CAS 4394-00-7

Ácido niflúmico

Descripción:

Ácido niflúmico es un fármaco antiinflamatorio no esteroideo (AINE) utilizado principalmente por sus propiedades analgésicas y antiinflamatorias. Pertenece a la clase de los ácidos arilacéticos y se caracteriza por su capacidad para inhibir las enzimas ciclooxigenasas, que desempeñan un papel crucial en la síntesis de prostaglandinas involucradas en la inflamación y la señalización del dolor. La estructura química de Ácido niflúmico presenta un grupo 2,6-difluorobenzamida, que contribuye a su actividad farmacológica. Se administra típicamente en forma oral y es conocido por su rápida absorción y metabolismo. Ácido niflúmico exhibe una variedad de efectos terapéuticos, incluyendo el alivio del dolor asociado con diversas condiciones como la artritis y la dismenorrea. Sin embargo, al igual que otros AINE, puede estar asociado con efectos secundarios gastrointestinales y riesgos cardiovasculares, lo que requiere una cuidadosa consideración de su uso en pacientes con condiciones preexistentes. Su número CAS, 4394-00-7, es un identificador único que facilita la identificación y el estudio de este compuesto en la literatura científica y en contextos regulatorios.

Fórmula: C₁₃H₉F₃N₂O₂

InChI: InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)

Clave InChI: InChIKey=JZFPYUNJRRFVQU-UHFFFAOYSA-N

SMILES: N(C1=C(C(O)=O)C=CC=N1)C2=CC(C(F)(F)F)=CC=C2

Sinónimos:

• 2-(Alpha,Alpha,Alpha-Trifluoro-M-Toluidino)Nicotinic Acid
• 2-[3-(Trifluoromethyl)-phenyl]aminonicotinic acid
• 2-[3-(Trifluoromethyl)anilino]-3-pyridinecarboxylic acid
• 2-[3-(Trifluoromethyl)anilino]nicotinic acid
• 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
• 2-{[3-(Trifluoromethyl)Phenyl]Amino}Nicotinic Acid
• 2-{[3-(Trifluoromethyl)Phenyl]Amino}Pyridine-3-Carboxylate
• 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-
• Acide Niflumique
• Acido Niflumico
• Actol
• Actol (analgesic)
• Donalgin
• Flogovital
• Forenol
• Landruma
• N-(α,α,α-Trifluoro-m-tolyl)nicotinic acid
• Nicotinic acid, 2-(α,α,α-trifluoro-m-toluidino)-
• Niflamol
• Nifluminic acid
• Nifluminsaure
• Nifluril
• Up 83

Niflumic Acid

CAS: 4394-00-7

Fórmula: C₁₃H₉F₃N₂O₂

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 282.22

Ref: 3B-T2353

Niflumic acid, 99+%

CAS: 4394-00-7

It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label info

Fórmula: C₁₃H₉F₃N₂O₂

Pureza: 99+%

Forma y color: Powder or crystals or crystalline powder

Peso molecular: 282.22

Ref: 02-J60489

Niflumic Acid

CAS: 4394-00-7

Forma y color: Neat

Ref: 61-FOR0850.00

NIFLUMIC ACID CRS

CAS: 4394-00-7

NIFLUMIC ACID CRS

Fórmula: C₁₃H₉F₃N₂O₂

Forma y color: Crystalline Powder. Light Yellow. Powder.

Peso molecular: 282.218

Ref: 41-Y0000824

2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid

CAS: 4394-00-7

Fórmula: C₁₃H₉F₃N₂O₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 282.2180

Ref: IN-DA003T3S

Niflumic acid

CAS: 4394-00-7

Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.

Fórmula: C₁₃H₉F₃N₂O₂

Pureza: 99.47%

Forma y color: Solid

Peso molecular: 282.22

Ref: TM-T0693

Niflumic acid

CAS: 4394-00-7

Niflumic acid

Pureza: ≥98%

Peso molecular: 282.22g/mol

Ref: 54-BUP14952

Niflumic acid

CAS: 4394-00-7

Niflumic acid

Pureza: 98%

Peso molecular: 282.22g/mol

Ref: 54-PC908706

Niflumic acid

CAS: 4394-00-7

Fórmula: C₁₃H₉F₃N₂O₂

Peso molecular: 282.22

Ref: 7W-GL5205

Niflumic acid

Producto controlado

CAS: 4394-00-7

Fórmula: C₁₃H₉F₃N₂O₂

Forma y color: Neat

Peso molecular: 282.22

Ref: 04-C15522500

Niflumic Acid

Producto controlado

CAS: 4394-00-7

Fórmula: C₁₃H₉F₃N₂O₂

Forma y color: Neat

Peso molecular: 282.22

Ref: 86-MM0850.00

Niflumic Acid

CAS: 4394-00-7

Fórmula: C₁₃H₉F₃N₂O₂

Forma y color: Off-White Solid

Peso molecular: 282.22

Ref: 4Z-N-123001

Niflumic Acid

Producto controlado

CAS: 4394-00-7

Applications Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Glasson, et al.: Biochem, Pharmacol., 18, 633 (1969), Boissier, et al.: Therapie, 26, 211 (1971), Sorenson, J.R.J., et al.: J. Med. Chem., 19, 135 (1976), Barnett, J., et al.: Biochim. Biophys. Acta, 1209, 130 (1994), Johnson, J.L., et al.: Arch. Biochem. Biophys., 324, 26 (1995),

Fórmula: C₁₃H₉F₃N₂O₂

Forma y color: Light Yellow

Peso molecular: 282.22

Ref: TR-N457500

Niflumic acid

CAS: 4394-00-7

Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the function of cyclooxygenase and 5-lipoxygenase. It has been shown to inhibit P-glycoprotein (P-gp) in vitro. Inhibition of P-gp leads to an increase in the intracellular levels of Ca2+ and activation of the ryanodine receptor, which is a protein found on the endoplasmic reticulum. This results in an increase in cellular excitability, which can lead to cell death. Niflumic acid also inhibits picolinic acid and pyrazinoic acid production, which are toxic metabolites that may play a role in its anti-inflammatory effects.

Fórmula: C₁₃H₉F₃N₂O₂

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 282.22 g/mol

Ref: 3D-FN26214

Niflumic Acid

CAS: 4394-00-7

M02156 - Niflumic Acid

Fórmula: C₁₃H₉F₃N₂O₂

Pureza: 95%

Forma y color: Solid, Slightly pale yellow to yellow powder

Peso molecular: 282.222

Ref: 10-M02156