CAS 4562-36-1

Gitoxina

Descripción:

Gitoxina, con el número CAS 4562-36-1, es un glucósido cardíaco que se deriva de la especie vegetal Digitalis, comúnmente conocida como dedalera. Se caracteriza por su capacidad para inhibir la enzima Na+/K+ ATPasa, lo que lleva a un aumento de las concentraciones intracelulares de sodio y calcio en las células cardíacas. Este mecanismo aumenta la fuerza de las contracciones cardíacas, lo que lo hace útil en el tratamiento de ciertas afecciones cardíacas, como la fibrilación auricular y la insuficiencia cardíaca. Gitoxina presenta un índice terapéutico estrecho, lo que significa que la diferencia entre una dosis efectiva y una dosis tóxica es pequeña, lo que requiere un monitoreo cuidadoso de los niveles de sangre durante el tratamiento. La sustancia también es conocida por sus posibles efectos secundarios, que pueden incluir trastornos gastrointestinales, cambios visuales y arritmias. Al igual que otros glucósidos cardíacos, la farmacocinética de Gitoxina puede verse influenciada por factores como la función renal y las interacciones con otros medicamentos. Debido a sus efectos potentes y su posible toxicidad, Gitoxina debe ser utilizado bajo estricta supervisión médica.

Fórmula: C₄₁H₆₄O₁₄

InChI: InChI=1S/C41H64O14/c1-19-36(47)27(42)14-33(50-19)54-38-21(3)52-34(16-29(38)44)55-37-20(2)51-32(15-28(37)43)53-24-8-10-39(4)23(13-24)6-7-26-25(39)9-11-40(5)35(22-12-31(46)49-18-22)30(45)17-41(26,40)48/h12,19-21,23-30,32-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25+,26-,27+,28+,29+,30+,32+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

Clave InChI: InChIKey=LKRDZKPBAOKJBT-CNPIRKNPSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H]([C@@H](O)C2)C8=CC(=O)OC8)[H])[H]

Sinónimos:

• (3beta,5beta,16beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14,16-dihydroxycard-20(22)-enolide
• (3beta,5beta,9xi,16beta)-3-{[(4xi)-2,6-dideoxy-D-erythro-hexopyranosyl-(1->4)-2,6-dideoxy-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14,16-dihydroxycard-20(22)-enolide
• (3β,5β,16β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14,16-dihydroxycard-20(22)-enolide
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-14,16-Dihydroxycard-20(22)-Enolide
• Anhydrogitalin
• Bigitalin
• Brn 0077015
• Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14,16-dihydroxy-, (3beta,5beta,16beta)- (9CI)
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-, (3β,5β,16β)-
• Gitoksin
• Gitoxigenin-tridigitoxosid
• Gitoxigenin-tridigitoxosid [German]
• Gitoxim
• Gitoxoside
• Nsc 95099
• Pseudodigitoixn
• Pseudodigitoxin
• Gitoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-, (3β,5β,16β)-
• (3β,5β,16β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxycard-20(22)-enolide
• Gitoxin extrapure, 98%
• 20(22),5BETA-CARDENOLID-3BETA,14BETA,16BETA-TRIOL 3BETA-[O-BETA-D-DIGITOXOPYRANOSYL-(1->4)-O-BETA-D-DIGITOXOPYRANOSYL-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE]
• Gitoxin CRS
• Digoxin Impurity 15
• Anhydrogitalin, Pseudodigitoxin
• 16-Hydroxydigitoxin
• GINSENOSIDES KIT
• 3β-[[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-14,16β-dihydroxy-5β-card-20(22)-enolide
• Digoxin EP Impurity B
• Digoxin IMpurity B
• Gitoxin (50 mg)
• ACETYL GITOXIN, 16-(RG)
• Gitoxin for Purity RS

Gitoxin

CAS: 4562-36-1

Gitoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₄₁H₆₄O₁₄

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 780.95

Ref: 11-0823S

GITOXIN CRS

CAS: 4562-36-1

GITOXIN CRS

Fórmula: C₄₁H₆₄O₁₄

Forma y color: Crystalline Powder. White. Powder.

Peso molecular: 780.9385

Ref: 41-G0300000

Gitoxin

CAS: 4562-36-1

Gitoxin

Pureza: 95%

Peso molecular: 780.94g/mol

Ref: 54-OR1075482

Gitoxin

CAS: 4562-36-1

Gitoxin is a natural Na⁺/K⁺-ATPase inhibitor and metabolite of digitoxin, antiarrhythmic with μM-level inhibition of human erythrocyte isoenzymes.

Fórmula: C₄₁H₆₄O₁₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 780.94

Ref: TM-TN4134

Digoxin EP Impurity B

CAS: 4562-36-1

Fórmula: C₄₁H₆₄O₁₄

Peso molecular: 780.95

Ref: 4Z-D-753

Gitoxin

CAS: 4562-36-1

Fórmula: C₄₁H₆₄O₁₄

Pureza: ≥ 95%

Forma y color: White solid

Peso molecular: 780.94

Ref: 7W-GW0261

Gitoxin for Purity RS

CAS: 4562-36-1

Forma y color: White Solid Crystalline Powder

Ref: 2K-1044000021

Gitoxin

CAS: 4562-36-1

Gitoxin is a protein analog that has been shown to increase the strength of heart tissue. It has been shown to be effective in treating congestive heart failure, which is characterized by symptoms such as shortness of breath and fatigue. Gitoxin also inhibits inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Gitoxin is a growth factor that stimulates the proliferation of human serum cells, with an effect on basic fibroblast growth factor (bFGF). Gitoxin has been shown to have cardiac effects and may inhibit cardiac arrhythmias by binding to the papillary muscle. There are kinetic studies that show gitoxin binding to the cardiac potassium channels and activating them.

Fórmula: C₄₁H₆₄O₁₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 780.96 g/mol

Ref: 3D-FG08665

Gitoxin extrapure, 98%

CAS: 4562-36-1

Pureza: -98%

Ref: SR-56397

Gitoxin

CAS: 4562-36-1

Pureza: 98%

Peso molecular: 780.9489746

Ref: 10-F618825

Digoxin EP Impurity B

CAS: 4562-36-1

Fórmula: C₄₁H₆₄O₁₄

Peso molecular: 780.9

Ref: ST-EA-CP-D1200002

Gitoxin

Producto controlado

CAS: 4562-36-1

Stability Hygroscopic
Applications Gitoxin acts as in inhibitor of the sodium and potassium ion channels, interfering with ATPase activity and used in cancer treatment as a growth inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Colovic, M. et al.: Russ. J. Phys. Chem. A., 83, 1602 (2009); Banuls, L. et al.: Mol. Canc., 12, 33 (2013);

Fórmula: C₄₁H₆₄O₁₄

Forma y color: Neat

Peso molecular: 780.94

Ref: TR-G388750