CAS 461432-26-8

Dapagliflozina

Descripción:

Dapagliflozina es un medicamento utilizado principalmente en el manejo de la diabetes mellitus tipo 2. Pertenece a la clase de fármacos conocidos como inhibidores del cotransportador de sodio-glucosa 2 (SGLT2), que actúan previniendo la reabsorción de glucosa en los riñones, promoviendo así su excreción en la orina y reduciendo los niveles de glucosa en sangre. La fórmula química de Dapagliflozina es C21H25ClO6S, y presenta un grupo sulfonilo, un grupo clorofenilo y una estructura similar a la glucosa que facilita su mecanismo de acción. Dapagliflozina se administra típicamente por vía oral y a menudo se prescribe en conjunto con otros agentes antidiabéticos para mejorar el control glucémico. Además de sus efectos reductores de glucosa, se ha asociado con la pérdida de peso y una reducción de la presión arterial. Los efectos secundarios comunes pueden incluir infecciones del tracto urinario e infecciones micóticas genitales debido al aumento de glucosa en la orina. En general, Dapagliflozina representa un avance significativo en el tratamiento de la diabetes, ofreciendo un enfoque único para el manejo de los niveles de azúcar en sangre.

Fórmula: C₂₁H₂₅ClO₆

InChI: InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

Clave InChI: InChIKey=JVHXJTBJCFBINQ-ADAARDCZSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2

Sinónimos:

• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-<span class="text-smallcaps">D</span>-glucitol
• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
• (1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol
• <span class="text-smallcaps">D</span>-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-
• Bms-512148
• D-Glucitol, 1,5-Anhydro-1-C-[4-Chloro-3-[(4-Ethoxyphenyl)Methyl]Phenyl]-, (1S)-
• Dapagliflozin
• Dapagliflozin free base
• (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol

CAS: 461432-26-8

Fórmula: C₂₁H₂₅ClO₆

Pureza: 97%

Forma y color: Solid

Peso molecular: 408.8726

Ref: IN-DA0039GJ

Dapagliflozin-13C6 (Glucitol-13C6)

CAS: 461432-26-8

Fórmula: C₁₅₁₃C₆H₂₅ClO₆

Peso molecular: 414.83

Ref: 4Z-D-6251

Dapagliflozin

CAS: 461432-26-8

Fórmula: C₂₁H₂₅ClO₆

Forma y color: White To Off-White Solid

Peso molecular: 408.88

Ref: 4Z-D-623

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin

Pureza: ≥98%

Peso molecular: 408.87g/mol

Ref: 54-BUP13385

Dapagliflozin-13C6

CAS: 461432-26-8

Fórmula: C₁₅₁₃C₆H₂₅ClO₆

Peso molecular: 414.83

Ref: 4Z-D-6220

Dapagliflozin

CAS: 461432-26-8

Fórmula: C₂₁H₂₅ClO₆

Pureza: ≥ 98.0% (dried basis)

Forma y color: White to light-yellow powder

Peso molecular: 408.87

Ref: 7W-GP5853

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin

Pureza: 98%

Peso molecular: 408.87g/mol

Ref: 54-OR1030481

Dapagliflozin

CAS: 461432-26-8

Fórmula: C₂₁H₂₅ClO₆

Pureza: >95.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 408.88

Ref: 3B-D6234

Dapagliflozin

CAS: 461432-26-8

Forma y color: Neat

Ref: 04-C11962000

Dapagliflozin

CAS: 461432-26-8

Fórmula: C₂₁H₂₅ClO₆

Forma y color: Neat

Peso molecular: 408.87

Ref: 86-MM3611.04

Dapagliflozin-d7

CAS: 461432-26-8

Fórmula: C₂₁H₁₈ClO₆D₇

Peso molecular: 415.93

Ref: 4Z-D-622

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.

Fórmula: C₂₁H₂₅ClO₆

Pureza: 99.5% - 99.93%

Forma y color: Solid

Peso molecular: 408.87

Ref: TM-T2389

DAPAGLIFLOZIN

CAS: 461432-26-8

Pureza: 98%

Peso molecular: 408.8800048828125

Ref: 10-F794039

Dapagliflozin

CAS: 461432-26-8

Stability Hygroscopic
Applications A sodium-glucose transporter 2 inhibitor.
References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)

Fórmula: C₂₁H₂₅ClO₆

Forma y color: Neat

Peso molecular: 408.87

Ref: TR-D185370

Dapagliflozin - Bio-X ™

CAS: 461432-26-8

Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. It inhibits glucose reabsorption in the proximal tubule of the nephron and results in glycosuria, which helps to improve glycaemic control. Also, Dapagliflozin is used to lower the risk of sustained eGFR decline, end-stage renal disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease who are at risk of progression.

Fórmula: C₂₁H₂₅ClO₆

Pureza: Min. 99 Area-%

Forma y color: Powder

Peso molecular: 408.87 g/mol

Ref: 3D-BD164346

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. SGLT2 is located in the proximal convoluted tubule and when it is inhibited the reabsorption of glucose into the kidneys is prevented and instead glucose is excreted in the urine. As a result glucose levels are reduced. Dapagliflozin is metabolized into to its inactive metabolite 3-O-glucuronide by the UGT1A9 enzyme present in the liver and the kidneys. In addition, dapagliflozin has been shown to cause weight loss and decrease the risk of cardiovascular events such as congestive heart failure.

Fórmula: C₂₁H₂₅ClO₆

Pureza: Min. 98 Area-%

Forma y color: White Yellow Powder

Peso molecular: 408.87 g/mol

Ref: 3D-MD20795