CAS 469-83-0
:Cafestol
Descripción:
Cafestol es un compuesto natural que se encuentra principalmente en el café, particularmente en las infusiones de café sin filtrar. Es un diterpeno, específicamente un tipo de labdano, y se conoce por su estructura similar a los lípidos. Cafestol es reconocido por sus posibles efectos sobre la salud, incluyendo su capacidad para aumentar los niveles de colesterol en la sangre, lo que ha sido objeto de investigación en relación con el consumo de café y la salud cardiovascular. El compuesto también se destaca por sus propiedades antioxidantes, contribuyendo a los beneficios generales para la salud asociados con el café. Cafestol es soluble en disolventes orgánicos pero tiene una solubilidad limitada en agua, lo cual es típico de muchos compuestos lipofílicos. Su presencia en el café varía significativamente dependiendo del método de preparación; por ejemplo, métodos como la prensa francesa o el café turco retienen más Cafestol en comparación con el café filtrado. Comprender las características de Cafestol es esencial para evaluar su impacto en la salud y la nutrición, así como su papel en la compleja química del café.
Fórmula:C20H28O3
InChI:InChI=1/C20H28O3/c1-18-7-5-16-14(6-9-23-16)15(18)4-8-19-10-13(2-3-17(18)19)20(22,11-19)12-21/h6,9,13,15,17,21-22H,2-5,7-8,10-12H2,1H3/t13?,15-,17+,18-,19+,20+/m1/s1
Clave InChI:InChIKey=DNJVYWXIDISQRD-HWUKTEKMSA-N
SMILES:C[C@]12[C@]3([C@]4(C[C@]([C@](CO)(O)C4)(CC3)[H])CC[C@@]1(C5=C(CC2)OC=C5)[H])[H]
Sinónimos:- (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
- (3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- (3bS,5aS,7R,8S,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-
- 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, (3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-
- 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, [3bS-(3bα,5aβ,7β,8β,10aα,10bβ)]-
- Cafesterol
- Ccris 1518
- Cafestol
- 3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol
- Cafestol (>85%)
- Ver más sinónimos
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Encontrado 10 productos.
Cafestol
CAS:<p>Natural extract from coffee beans which induces glutathione S-transferase</p>Fórmula:C20H28O3Forma y color:White to off white, PowderPeso molecular:316.44Cafestol
CAS:Fórmula:C20H28O3Pureza:≥ 98.0%Forma y color:White to off-white powderPeso molecular:316.44Cafestol
CAS:Cafestol has anticarcinogenic, peripheral antinociceptive and anti-inflammatory activities, it inhibits Cyclic-Strain-induced interleukin-8, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 production in vascular endothelial cells. Cafestol is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis. Cafestol has protective effects against the CCl(4)-induced hepatotoxicity, which possibly involve mechanisms related to its ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects. Cafestol has antidiabetic activity, it increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. Cafestol also has a weak inhibitory effect on osteoclastogenesis and promotes osteoblast differentiation.Fórmula:C20H28O3Pureza:95%~99%Peso molecular:316.441CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Fórmula:C20H28O3Pureza:97.06% - 99.08%Forma y color:SolidPeso molecular:316.43Cafestol
CAS:Oxygen-heterocyclic compoundFórmula:C20H28O3Pureza:≥ 98.0 % (HPLC)Forma y color:PowderPeso molecular:316.44Cafestol (>85%)
CAS:Producto controlado<p>Applications Cafestol is a diterpene molecule that displays anti-carcinogenic properties in studies.<br>References Higgins, L.G. et al.: Tox. App. Pharma., 226, 328 (2008); Schilter, B. et al.: Carcinogenesis, 17, 2377 (1996);<br></p>Fórmula:C20H28O3Pureza:>85%Forma y color:NeatPeso molecular:316.43Cafestol
CAS:<p>Cafestol is a diterpene compound, which is primarily sourced from coffee beans. It is found in the oily fraction of coffee, particularly in unfiltered types like French press and Turkish coffee. Its mode of action involves influencing lipid metabolism in the liver. Specifically, cafestol acts as an agonist for certain nuclear receptors, including FXR and PXR, which play a role in bile acid regulation and lipid homeostasis.Cafestol is known to have a notable impact on cholesterol levels. It causes an increase in serum cholesterol by reducing the excretion of bile acids, consequently enhancing cholesterol reabsorption. Due to its pronounced effects on cholesterol metabolism, cafestol is a compound of interest in cardiovascular research, especially in the context of dietary factors influencing heart health. Scientists are exploring its broader implications on lipid-related diseases and how modifying coffee preparation methods can mitigate its impact on health.</p>Fórmula:C20H28O3Pureza:Min. 95%Forma y color:PowderPeso molecular:316.43 g/mol
