CAS 470-37-1

Cinobufagina

Descripción:

Cinobufagina es un compuesto que se encuentra de forma natural clasificado como un bufadienolido, que es un tipo de glucósido esteroidal. Se deriva principalmente de la piel de ciertos sapos, particularmente de aquellos del género Bufo. Este compuesto exhibe una variedad de actividades biológicas, incluyendo efectos cardiotónicos, que pueden influir en las contracciones del músculo cardíaco. Cinobufagina ha sido estudiado por sus posibles aplicaciones terapéuticas, particularmente en la medicina tradicional, donde se cree que posee propiedades anticancerígenas, antiinflamatorias e inmunomoduladoras. La sustancia se caracteriza por su compleja estructura molecular, que incluye un esqueleto esteroidal y grupos funcionales específicos que contribuyen a su actividad biológica. Sin embargo, debido a sus potentes efectos, Cinobufagina también puede exhibir toxicidad, lo que requiere una cuidadosa consideración en su uso. La investigación continúa explorando sus mecanismos de acción y posibles aplicaciones clínicas, al tiempo que aborda preocupaciones sobre la seguridad y la eficacia. Al igual que muchos compuestos naturales, el perfil farmacológico de Cinobufagina es de gran interés tanto en contextos medicinales tradicionales como modernos.

Fórmula: C₂₆H₃₄O₆

InChI: InChI=1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1

Clave InChI: InChIKey=SCULJPGYOQQXTK-OLRINKBESA-N

SMILES: C[C@]12[C@]3([C@](O3)([C@H](OC(C)=O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H]

Sinónimos:

• (3Beta,5Beta,15Beta,16Beta)-16-(Acetyloxy)-3-Hydroxy-14,15-Epoxybufa-20,22-Dienolide
• (3beta,5beta,8xi,9xi,10xi,13xi,14beta,15beta,16beta,17beta)-3-hydroxy-17-(2-oxo-2H-pyran-4-yl)-14,15-epoxyandrostan-16-yl acetate
• (3β,5β,15β,16β)-16-(Acetyloxy)-14,15-epoxy-3-hydroxybufa-20,22-dienolide
• 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
• 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,16β-dihydroxy-, 16-acetate
• Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)-
• Cinobufagenin
• Cinobufagin
• Cinobufagine
• Cinobufogenin
• NSC 90325

Cinobufagine

CAS: 470-37-1

Fórmula: C₂₆H₃₄O₆

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 442.55

Ref: 3B-C3460

Cinobufagin

CAS: 470-37-1

Fórmula: C₂₆H₃₄O₆

Pureza: ≥ 98.0%

Forma y color: White or off-white powder

Peso molecular: 442.54

Ref: 7W-GP7595

Cinobufagin

CAS: 470-37-1

Cinobufagin

Pureza: ≥95%

Peso molecular: 442.54g/mol

Ref: 54-BUP07390

Cinobufagin

CAS: 470-37-1

Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer, it also has anti-hepatitis B virus activity . Cinobufagin inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway. Cinobufagin can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue.Cinobufagin and bufalin exhibit cardiotonic and natriuretic activities, they also have inhibitory effects on steroidogenesis of aldosterone and cortisol.

Fórmula: C₂₆H₃₄O₆

Pureza: 95%~99%

Peso molecular: 442.552

Ref: BP-BP0366

Cinobufagin

CAS: 470-37-1

Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.

Fórmula: C₂₆H₃₄O₆

Pureza: 97.77% - 99.97%

Forma y color: Solid

Peso molecular: 442.54

Ref: TM-T3432

Cinobufagin

CAS: 470-37-1

Lactone

Fórmula: C₂₆H₃₄O₆

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 442.55

Ref: 5G-89609

Cinobufagine-d3

Producto controlado

CAS: 470-37-1

Applications Isotope labelled Cinobufagine (C475500) is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Fórmula: C₂₆H₃₁D₃O₆

Forma y color: White To Off-White

Peso molecular: 445.56

Ref: TR-C475502

Cinobufagin - Bio-X ™

CAS: 470-37-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₆H₃₄O₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 442.54 g/mol

Ref: 3D-BC300057

Cinobufagin

CAS: 470-37-1

Cinobufagin is a bufadienolide compound, which is a type of steroid. It is sourced from the venom of the Chinese toad, Bufo bufo gargarizans, commonly used in traditional Chinese medicine. The compound exerts its effects primarily through the modulation of cellular signaling pathways, such as inhibiting the Na+/K+-ATPase pump, which leads to alterations in ion gradients and subsequent induction of apoptosis in cancer cells.

Fórmula: C₂₆H₃₄O₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 442.54 g/mol

Ref: 3D-FC65673

Cinobufagine

Producto controlado

CAS: 470-37-1

Applications Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Fórmula: C₂₆H₃₄O₆

Forma y color: Neat

Peso molecular: 442.54

Ref: TR-C475500