CAS 472-15-1

Ácido betulínico

Descripción:

Ácido betulínico es un compuesto triterpenoide pentacíclico que se encuentra de forma natural, derivado principalmente de la corteza del abeto (especies de Betula). Se caracteriza por su apariencia cristalina blanca y tiene una fórmula molecular de C30H48O3. Ácido betulínico es conocido por sus diversas actividades biológicas, incluyendo propiedades antiinflamatorias, antivirales y anticancerígenas. Se ha estudiado por sus posibles efectos terapéuticos contra varios tipos de cáncer, ya que puede inducir apoptosis en células tumorales mientras preserva las células normales. Además, Ácido betulínico exhibe propiedades antimicrobianas y ha mostrado promesas en el tratamiento de condiciones como el VIH y otras infecciones virales. Su mecanismo de acción a menudo implica la modulación de las vías de señalización celular y la inducción de estrés oxidativo en células cancerosas. Debido a su origen natural y bioactividad, Ácido betulínico es de gran interés en la investigación y desarrollo farmacéutico, aunque se necesitan más estudios para comprender completamente su eficacia y seguridad en aplicaciones clínicas.

Fórmula: C₃₀H₄₈O₃

InChI: InChI=1/C29H46O3/c1-17(2)18-9-15-29(25(31)32)16-10-20-19(24(18)29)7-8-22-27(20,5)13-11-21-26(3,4)23(30)12-14-28(21,22)6/h18-24,30H,1,7-16H2,2-6H3,(H,31,32)/t18-,19-,20?,21?,22?,23+,24?,27-,28-,29-/m0/s1

Clave InChI: InChIKey=QGJZLNKBHJESQX-FZFNOLFKSA-N

SMILES: C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

Sinónimos:

• (1R,3aS,5bS,9R,11aR,13aS)-9-hydroxy-5b,8,8,11a-tetramethyl-1-(1-methylethenyl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid
• (3Beta)-3-Hydroxylup-20(29)-En-28-Oic Acid
• (3Beta,5Xi,9Xi,13Xi,18Xi)-3-Hydroxylup-20(29)-En-28-Oic Acid
• (3β)-3-Hydroxylup-20(29)-en-28-oic acid
• 3-Hydroxylup-20(29)-en-28-oic acid
• 3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv.
• 3β-Hydroxylup-20(29)-en-28-oic acid
• Acide Lupene-20(29) Oique-28, Hydroxy-3, (3Β)-
• Acido Lup-20(29)-En-28-Oico, 3-Hidroxi-, (3Β)-
• Betulic acid
• Ccris 6748
• Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-
• Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3β)-
• Lup-20(29)-en-28-oic acid, 3beta-hydroxy-
• Lup-20(29)-en-28-oic acid, 3β-hydroxy-
• Lup-20(29)-en-28-olsaure, 3-Hydroxy-, (3β)-
• Lupatic acid
• Mairin
• Nsc 113090
• Nsc 677578
• β-Betulinic acid
• Platanol
• BETULICACID: LUP-20(29)-EN-28-OICACID, 3-HYDROXY-, (3B)-,
• Betulinic
• (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentaMethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid
• BETULINIC ACID
• AIRIN
• 3-B-HYDROXY-LUPA-20(30)-ENE 28-OIC ACID
• 3BETA-HYDROXY-20(29)-LUPENE-28-OIC ACID
• Einecs 207-448-8
• Melaleucin
• Gratiolone
• 3BETA-HYDROXY-20(29)-LUPAENE-28-OIC ACID
• ALS-357
• BETULINIC ACID WITH HPLC
• 3β-hydroxy-20(29)-lupaene-28-oic acid
• BETULINIC ACID hplc
• 3B-HYDROXY-20(29)-LUPENE-28-OIC ACID
• Betulinic acid technical grade, 90%
• (+)-(3β)-3-Hydroxylup-20(29)-en-28-oicacid
• Lup-20(29)-en-28-oic acid, 3beta-hydroxy-(8ci)
• 3β-hydroxy-lup-20(29)-ene-28-oicacid
• Betulinic Acid(98%)
• Platanolic acid
• BETULINIC ACID, TECH., 90%

Betulinic acid

CAS: 472-15-1

Betulinic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₃₀H₄₈O₃

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 456.71

Ref: 11-0031S

Betulinic acid

CAS: 472-15-1

Fórmula: C₃₀H₄₈O₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 456.7003

Ref: IN-DA003O6L

Betulinic acid

CAS: 472-15-1

Fórmula: C₃₀H₄₈O₃

Pureza: ≥ 97.0%

Forma y color: White to off-white or light-yellow powder

Peso molecular: 456.70

Ref: 7W-GP1450

Betulinic acid

CAS: 472-15-1

Betulinic acid

Pureza: ≥98%

Peso molecular: 456.7g/mol

Ref: 54-BUP16011

Betulinic acid

CAS: 472-15-1

Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli.

Fórmula: C₃₀H₄₈O₃

Pureza: 95%~99%

Peso molecular: 456.711

Ref: BP-BP0271

Betulinic acid

CAS: 472-15-1

Betulinic acid

Fórmula: C₃₀H₄₈O₃

Pureza: 98%

Forma y color: white powder

Peso molecular: 456.70g/mol

Ref: 54-BIDF1001

Betulinic acid

CAS: 472-15-1

Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.

Fórmula: C₃₀H₄₈O₃

Pureza: 98.22% - 99.7%

Forma y color: White Crystalline Powder

Peso molecular: 456.70

Ref: TM-T2830

Betulinic acid with hplc

CAS: 472-15-1

Betulinic acid with hplc

Pureza: 98%

Peso molecular: 456.70g/mol

Ref: 54-BIDF1011

Betulinic acid

CAS: 472-15-1

Carboxylic acid with alcohol function

Fórmula: C₃₀H₄₈O₃

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 456.71

Ref: 5G-89529

Betulinic Acid

CAS: 472-15-1

Applications Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);

Fórmula: C₃₀H₄₈O₃

Forma y color: Neat

Peso molecular: 456.70

Ref: TR-B330250

Betulinic Acid-d3

Producto controlado

CAS: 472-15-1

Applications Betulinic Acid-d3 is the isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity.
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

Fórmula: C₃₀H₄₅D₃O₃

Forma y color: Neat

Peso molecular: 459.72

Ref: TR-B330252

Betulinic acid

CAS: 472-15-1

Betulinic acid is a pentacyclic triterpenoid, which is derived from the bark of birch trees among other plants. This compound exerts its effects primarily through the induction of apoptosis in cancer cells, interference with viral replication, and modulation of inflammatory pathways. Its mode of action includes mitochondrial membrane potential disruption, inhibition of topoisomerase, and interaction with the NF-kB signaling pathway.

Fórmula: C₃₀H₄₈O₃

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 456.7 g/mol

Ref: 3D-FB16425

3-epi-Betulinic Acid-d3

Producto controlado

CAS: 472-15-1

Applications 3-epi-Betulinic Acid-d3 is an isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. In addition, 3-epi-Betulinic Acid-d3 is an epimer by-product isomer of Betulinic Acid-d3 (B330252).
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

Fórmula: C₃₀D₃H₄₅O₃

Forma y color: Neat

Peso molecular: 459.719

Ref: TR-B330251

Betulinic Acid

CAS: 472-15-1

Fórmula: C₃₀H₄₈O₃

Pureza: >97.0%(GC)(T)

Forma y color: White to Light yellow to Light orange powder to crystal

Peso molecular: 456.71

Ref: 3B-B2836

Betulinic acid

CAS: 472-15-1

M01408 - Betulinic acid

Fórmula: C₃₀H₄₈O₃

Pureza: 97%

Forma y color: Solid, Crystalline Powder or Powder

Peso molecular: 456.711

Ref: 10-M01408