CAS 474-25-9

Ácido quenodesoxicólico

Descripción:

Ácido quenodesoxicólico (CDCA) es un ácido biliar que juega un papel crucial en la digestión y absorción de grasas dietéticas y vitaminas liposolubles en el intestino. Es un polvo cristalino blanco a blanco amarillento que es soluble en agua y en disolventes orgánicos como el etanol y el metanol. El CDCA se sintetiza en el hígado a partir del colesterol y es un ácido biliar primario, lo que significa que se produce directamente a partir del colesterol en lugar de derivarse de otros ácidos biliares. Su estructura química presenta un núcleo esteroide con grupos hidroxilo en posiciones específicas, lo que contribuye a su naturaleza anfipática, que le permite emulsionar grasas. El CDCA está involucrado en la regulación del metabolismo del colesterol y se ha estudiado por su potencial terapéutico en condiciones como los cálculos biliares y ciertas enfermedades hepáticas. Además, puede influir en el microbioma intestinal y tiene implicaciones en la salud metabólica. Como sustancia de origen natural, también se utiliza en diversas formulaciones farmacéuticas y suplementos dietéticos.

Fórmula: C₂₄H₄₀O₄

InChI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

Clave InChI: InChIKey=RUDATBOHQWOJDD-BSWAIDMHSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Sinónimos:

• (3Alpha,5Beta,7Alpha,8Xi,9Xi,14Xi)-3,7-Dihydroxycholan-24-Oic Acid
• (3Alpha,5Beta,7Alpha,8Xi,9Xi,14Xi)-3,7-Dihydroxycholan-24-Oicacid
• (3α,5β,7α)-3,7 Dihydroxycholan-24-oic acid
• (5Beta)-3,7-Dihydroxycholan-24-Oic Acid
• (5Beta)-3,7-Dihydroxycholan-24-Oicacid
• 17β-(1-Methyl-3-carboxypropyl)etiocholane-3α,7α-diol
• 3-Alpha,7-Alpha-Dihydroxy-5-Beta-Cholan-24-Oicacid
• 3alpha,7alpha-Dihydroxy-5beta-cholanic acid
• 3α,7α-Dihydroxy-5β-cholan-24-oic acid
• 3α,7α-Dihydroxy-5β-cholanic acid
• 3α,7α-Dihydroxy-5β-cholanoic acid
• 3α,7α-Dihydroxycholanic acid
• 5β-Cholan-24-oic acid, 3α,7α-dihydroxy-
• 5β-Cholanic acid, 3α,7α-dihydroxy-
• 7α-Hydroxylithocholic acid
• Acide chenodesoxycholique
• Acido Chenodeoxicholico
• Anthropodeoxycholic acid
• Anthropodesoxycholic acid
• Anthropododesoxycholic acid
• CDC
• CHOLANIC ACID, 3-α, 7-α-DIHYDROXY-5-β-
• Cdca
• Chendeoxycholicacid
• Chendol
• Chenic acid
• Chenix
• Chenocedon
• Chenocol
• Chenodeoxcholic acid
• Chenodesoxycholic acid
• Chenodesoxycholsaure
• Chenodex
• Chenodiol
• Chenofalk
• Chenossil
• Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7α)-
• Cholanorm
• Fluibil
• Gallodesoxycholic acid
• Hekbilin
• Kebilis

Chenodeoxycholic Acid

Producto controlado

CAS: 474-25-9

Impurity Ursodeoxycholic Acid EP Impurity A
Applications Chenodeoxycholic Acid (Ursodeoxycholic Acid EP Impurity A) is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.
References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),

Fórmula: C₂₄H₄₀O₄

Forma y color: Neat

Peso molecular: 392.57

Ref: TR-C291900

Chenodeoxycholic acid

Producto controlado

CAS: 474-25-9

Chenodeoxycholic acid is a human primary bile acid which is also found the bile of geese. Its C-7 epimer, Ursodeoxycholic acid is found in bear’s bile. Both bile acids are used for the treatment of gallstones, although Ursodeoxycholic acid has shown superior efficacy (bear’s bile extracts are also used in Chinese medicine).

Fórmula: C₂₄H₄₀O₄

Pureza: Min. 95 Area-%

Forma y color: White Powder

Peso molecular: 392.57 g/mol

Ref: 3D-FC09675

Chenodeoxycholic Acid-[d9] in Methanol

CAS: 474-25-9

Methanol

Ref: BE-MD-1004D9XM-100

Chenodeoxycholic Acid-[13C3] in Methanol

CAS: 474-25-9

Methanol

Ref: BE-MC-1004XM-100

Chenodeoxycholic Acid in Methanol

CAS: 474-25-9

Methanol

Ref: BE-MU-1004YM-1000

Chenodeoxycholic acid

CAS: 474-25-9

(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Fórmula: C₂₄H₄₀O₄

Pureza: 98+%

Peso molecular: 392.57

Ref: IN-DG764669

Chenodeoxycholic Acid-d7 (Major)

Producto controlado

CAS: 474-25-9

Applications Chenodeoxycholic Acid-d7 is a labelled analogue of Chenodeoxycholic Acid (C291900), which is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. In addition, Chenodeoxycholic Acid-d7 is an intermediate in synthesizing Glycochenodeoxycholic Acid-d7 Sodium Salt (G641257), which is a labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for
References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972); Iser, J.H., et al.: Drugs, 21, 90 (1981); Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986); Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005)

Fórmula: C₂₄H₃₃D₇O₄

Forma y color: Neat

Peso molecular: 399.62

Ref: TR-C291904

Chenodeoxycholic acid

Producto controlado

CAS: 474-25-9

Chenodeoxycholic acid is a human primary bile acid which is also found the bile of geese. Its C-7 epimer, Ursodeoxycholic acid is found in bear’s bile. Both bile acids are used for the treatment of gallstones, although Ursodeoxycholic acid has shown superior efficacy (bear’s bile extracts are also used in Chinese medicine).

Fórmula: C₂₄H₄₀O₄

Pureza: Min. 98 Area-%

Peso molecular: 392.58 g/mol

Ref: 3D-C-2900