CAS 475207-59-1

Nexavar

Descripción:

Nexavar, con el número CAS 475207-59-1, es el nombre comercial de sorafenib, un inhibidor de la tirosina quinasa de pequeñas moléculas utilizado principalmente en el tratamiento del cáncer. Se caracteriza por su capacidad para inhibir múltiples quinasas involucradas en la proliferación de células tumorales y la angiogénesis, incluyendo quinasas Raf y quinasas de receptor de tirosina como VEGFR y PDGFR. Sorafenib se administra típicamente por vía oral y es conocido por su papel en el tratamiento del carcinoma de células renales avanzado y el carcinoma hepatocelular. El compuesto es un sólido de color amarillo pálido a blanco sucio, con una fórmula molecular que incluye carbono, hidrógeno, nitrógeno, oxígeno y flúor. Su mecanismo de acción implica interrumpir las vías de señalización que promueven el crecimiento de células cancerosas y la formación de vasos sanguíneos, ralentizando así la progresión del tumor. Nexavar a menudo se asocia con efectos secundarios como fatiga, diarrea y reacciones cutáneas, que son consideraciones importantes en la gestión del paciente. En general, sorafenib representa un avance significativo en las terapias dirigidas contra el cáncer, ofreciendo un enfoque estratégico para combatir malignidades específicas.

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈SO₃

InChI: InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

Clave InChI: InChIKey=IVDHYUQIDRJSTI-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(NC)=O)N=CC1)C2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2.S(=O)(=O)(O)C1=CC=C(C)C=C1

Sinónimos:

• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1)
• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, mono(4-methylbenzenesulfonate)
• 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate
• BAY 43-9006 mono-p-tosylate
• Bay 54-9085
• N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Tolsylate
• Nexavar
• Sorafenib TsOH salt
• Sorafenib p-toluenesulfonate
• Sorafenib-D3
• Sorafenib tosylate

Sorafenib Tosylate

CAS: 475207-59-1

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 637.03

Ref: 3B-N1229

Sorafenib Tosylate

CAS: 475207-59-1

Forma y color: Neat

Ref: 61-FOR3585.00

SORAFENIB FOR PEAK IDENTIFICATION CRS

CAS: 475207-59-1

SORAFENIB FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002236

SORAFENIB TOSILATE CRS

CAS: 475207-59-1

SORAFENIB TOSILATE CRS

Ref: 41-Y0002224

SORAFENIB CRS

CAS: 475207-59-1

SORAFENIB CRS

Ref: 41-Y0002098

SORAFENIB FOR PEAK IDENTIFICATION A CRS

CAS: 475207-59-1

SORAFENIB FOR PEAK IDENTIFICATION A CRS

Ref: 41-Y0002488

Sorafenib Tosylate

CAS: 475207-59-1

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Forma y color: White Brown Powder

Peso molecular: 636.10572

Ref: 45-1615876

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-methylbenzene-1-sulfonic acid

CAS: 475207-59-1

Fórmula: C₂₈H₂₄ClF₃N₄O₆S

Pureza: 98%

Forma y color: Solid

Peso molecular: 637.0266

Ref: IN-DA0035M4

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Pureza: 99.24% - 99.94%

Forma y color: White To Off-White Crystalline Powder

Peso molecular: 637.03

Ref: TM-T0093

Sorafenib Tosylate

CAS: 475207-59-1

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Forma y color: Off-White Solid

Peso molecular: 464.83 172.20

Ref: 4Z-S-2738

Sorafenib tosylate

CAS: 475207-59-1

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Pureza: ≥ 98.0% (dried basis)

Forma y color: White, off-white or pale yellow-brown powder

Peso molecular: 637.03

Ref: 7W-GK5261

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib tosylate

Pureza: ≥98%

Peso molecular: 637.03g/mol

Ref: 54-BUP17105

Sorafenib Tosylate

Producto controlado

CAS: 475207-59-1

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Forma y color: Neat

Peso molecular: 637.03

Ref: 86-MM3585.00

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib tosylate

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Pureza: 99%+

Forma y color: off-white solid

Peso molecular: 637.03g/mol

Ref: 54-BISN0216

Sorafenib Tosylate

Producto controlado

CAS: 475207-59-1

Fórmula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Forma y color: Neat

Peso molecular: 637.03

Ref: TR-S676845

Sorafenib Tosylate

CAS: 475207-59-1

Fórmula: C₂₁H₁₆ClF₃N₄O₃C₇H₈O₃S

Peso molecular: 464.83 : 172.2

Ref: ST-EA-CP-S16021

Sorafenib tosylate - Bio-X ™

CAS: 475207-59-1

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib tosylate has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib tosylate also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes.
Sorafenib tosylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₁H₁₆ClF₃N₄O₃•C₇H₈O₃S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 637.03 g/mol

Ref: 3D-BS164414

Sorafenib, p-Toluenesulfonate Salt

CAS: 475207-59-1

Fórmula: C₃₅H₃₀F₃N₇O₄S

Pureza: 98%

Forma y color: Solid

Peso molecular: 701.73

Ref: 10-F050782

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib tosylate has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes.

Fórmula: C₂₁H₁₆ClF₃N₄O₃•C₇H₈O₃S

Pureza: Min. 95%

Forma y color: Off-White Powder

Peso molecular: 637.03 g/mol

Ref: 3D-FS10808