CAS 477-30-5

Demecolcina

Descripción:

Demecolcina es un compuesto químico clasificado como un derivado de la colchicina, conocido principalmente por su uso en investigación biológica y como un posible agente terapéutico. Se caracteriza por su capacidad para inhibir la polimerización de microtúbulos, lo que interrumpe la formación del huso mitótico, haciéndolo valioso en estudios de división celular e investigación del cáncer. Demecolcina se presenta típicamente como un polvo cristalino blanco a blanco amarillento, y es soluble en disolventes orgánicos como el dimetilsulfóxido (DMSO) y ligeramente soluble en agua. El compuesto tiene una fórmula molecular que refleja su estructura compleja, que incluye un anillo fenólico y un grupo metoxi. Debido a su actividad biológica, Demecolcina ha sido investigado por sus posibles aplicaciones en el tratamiento de ciertos tipos de cáncer y trastornos genéticos, aunque su uso a menudo está limitado por la toxicidad y los efectos secundarios. Al igual que con muchas sustancias químicas, el manejo adecuado y las precauciones de seguridad son esenciales al trabajar con Demecolcina en entornos de laboratorio.

Fórmula: C₂₁H₂₅NO₅

InChI: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

Clave InChI: InChIKey=NNJPGOLRFBJNIW-HNNXBMFYSA-N

SMILES: O(C)C1=C2C=3C([C@@H](NC)CCC2=CC(OC)=C1OC)=CC(=O)C(OC)=CC3

Sinónimos:

• (-)-Colchamine
• (7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
• (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one
• (N-Desacetyl-N-methylcolchicine)
• 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• Alkaloid H 3, from Colchicum antumnale
• Alkaloid H 3, from Colchicumantumnale
• Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
• Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-
• C 12669
• Ciba 12669A
• Colcemid
• Colcemide
• Colchamin
• Colchicine, N-deacetyl-N-methyl-
• Deacetyl-N-methylcolchicine
• Deacetylmethylcolchicine
• Demecolcin
• Demecolcina
• Demecolcine
• Demecolcine, (S)-(-)-
• Desacetylmethylcolchicine
• Desmecolcine
• Kolchamin
• N-Deacetyl-N-methylcolchicine
• N-Methyl-N-deacetylcolchicine
• N-Methyl-N-desacetylcolchicine
• N-Methyltri-O-methylcolchicinic acid
• Nsc 3096
• Omain
• Omaine
• Reichstein's F
• Santavy's substance F

Demecolcine

CAS: 477-30-5

Fórmula: C₂₁H₂₅NO₅

Pureza: 97%

Forma y color: Solid

Peso molecular: 371.4269

Ref: IN-DA00DDYO

Colcemid

CAS: 477-30-5

Colcemid

Pureza: ≥98%

Peso molecular: 371.43g/mol

Ref: 54-BUP02609

(-)-Demecolcine

CAS: 477-30-5

(-)-Demecolcine

Pureza: 97%

Peso molecular: 371.43g/mol

Ref: 54-OR1023885

Demecolcine

CAS: 477-30-5

Fórmula: C₂₁H₂₅NO₅

Pureza: ≥ 98.0%

Forma y color: White, off-white or pale yellow crystalline powder

Peso molecular: 371.43

Ref: 7W-GP5459

Demecolcine-13C,d3

CAS: 477-30-5

Fórmula: C₂₀₁₃CH₂₂D₃NO₅

Peso molecular: 375.44

Ref: 4Z-C-1530

Demecolcine

CAS: 477-30-5

Fórmula: C₂₁H₂₅NO₅

Peso molecular: 371.43

Ref: 4Z-C-1533

Demecolcine

CAS: 477-30-5

Stability Hygroscopic
Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

Fórmula: C₂₁H₂₅NO₅

Forma y color: Neat

Peso molecular: 371.43

Ref: TR-D230785

Colcemid

CAS: 477-30-5

Colcemid (NSC-3096) is a microtubule polymerization inhibitor,main target being Tubulin and an IC50 of 2.4 μM. induce apoptosis. High-Quality, Low-Cost!

Fórmula: C₂₁H₂₅NO₅

Pureza: 99.65% - 99.83%

Forma y color: Solid

Peso molecular: 371.43

Ref: TM-T19720

Demecolcine

CAS: 477-30-5

Demecolcine is a substance that is found in plants. It has been shown to have cytotoxic effects on human cells and to inhibit the growth of hl-60 cells by interfering with microtubule formation. Demecolcine binds to the microtubules, preventing them from polymerizing and causing mitotic arrest in cell cycle. Demecolcine also blocks the production of tubulin, which are proteins that are needed for microtubule formation. This drug has been shown to be effective against colchicine-resistant cells that are resistant to other cytotoxic agents as well. The rate constant for demecolcine's binding to microtubules is 0.2 s-1, which is higher than that of colchicine (0.05 s-1). The signal peptide sequence of demecolcine has been found in human chromosome 1q42 and chromosome 4q21, suggesting it may play a role in the

Fórmula: C₂₁H₂₅NO₅

Pureza: Min. 95%

Forma y color: Off-White Powder

Peso molecular: 371.43 g/mol

Ref: 3D-FC15451

Demecolcine

CAS: 477-30-5

Please enquire for more information about Demecolcine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fórmula: C₂₁H₂₅NO₅

Pureza: Min. 98 Area-%

Peso molecular: 371.43 g/mol

Ref: 3D-J-100064