CAS 480449-70-5

Edoxabán

Descripción:

Edoxabán es un anticoagulante oral que pertenece a la clase de inhibidores directos del factor Xa, que se utilizan principalmente para la prevención y el tratamiento de trastornos tromboembólicos, como la trombosis venosa profunda y la embolia pulmonar. Su mecanismo de acción implica la inhibición selectiva del factor Xa, una enzima esencial en la cascada de coagulación, reduciendo así la generación de trombina y previniendo la formación de coágulos. Edoxabán se caracteriza por su alta biodisponibilidad y farmacocinética predecible, lo que permite una dosificación fija sin necesidad de monitoreo rutinario de los parámetros de coagulación. La sustancia se administra típicamente en forma de tabletas y se metaboliza principalmente en el hígado, con la excreción renal desempeñando un papel significativo en su eliminación. Los efectos secundarios comunes pueden incluir complicaciones hemorrágicas, que son un riesgo asociado con todos los anticoagulantes. Edoxabán a menudo es preferido por su conveniencia y eficacia, lo que lo convierte en una opción valiosa en el manejo de diversas condiciones cardiovasculares.

Fórmula: C₂₄H₃₀ClN₇O₄S

InChI: InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1

Clave InChI: InChIKey=HGVDHZBSSITLCT-JLJPHGGASA-N

SMILES: N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3

Sinónimos:

• DU 176b
• Du 176
• Ethanediamide, N-(5-chloro-2-pyridinyl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
• Ethanediamide, N¹-(5-chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
• N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• N-(5-Chloropyridin-2-yl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• N¹-(5-Chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• Edoxaban
• Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
• N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide

Edoxaban

CAS: 480449-70-5

Edoxaban

Pureza: ≥95%

Peso molecular: 548.06g/mol

Ref: 54-BUP06398

Edoxaban

CAS: 480449-70-5

Fórmula: C₂₄H₃₀ClN₇O₄S

Peso molecular: 548.06

Ref: 4Z-E-080091

Edoxaban

Producto controlado

CAS: 480449-70-5

Fórmula: C₂₄H₃₀ClN₇O₄S

Forma y color: Neat

Peso molecular: 548.06

Ref: 86-MM3366.00

EDOXABAN

CAS: 480449-70-5

Pureza: 95%

Peso molecular: 548.059997558594

Ref: 10-F799088

Edoxaban

CAS: 480449-70-5

Fórmula: C₂₄H₃₀ClN₇O₄S

Forma y color: White

Peso molecular: 548.06

Ref: TR-E555520

Edoxaban

CAS: 480449-70-5

Edoxaban is an oral anticoagulant that inhibits thrombin, which is the main factor in the coagulation process. It has been shown to be effective for the prevention of atrial fibrillation and thromboembolism. The drug was also found to be safe and effective in a clinical trial of patients with atrial fibrillation who had undergone cardioversion. Edoxaban does not interact with other drugs, but may increase bleeding risk when combined with drugs such as warfarin. The drug has been shown to decrease levels of natriuretic peptides, which are hormones that help regulate blood pressure and fluid volume.

Fórmula: C₂₄H₃₀ClN₇O₄S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 548.06 g/mol

Ref: 3D-FC71602

Edoxaban

CAS: 480449-70-5

Edoxaban: potent, selective FXa inhibitor; Ki 0.561 nM. Used as an oral anticoagulant for stroke prevention, also inhibits thrombin and FIXa.

Fórmula: C₂₄H₃₀ClN₇O₄S

Pureza: 97.67% - 99.71%

Forma y color: Solid

Peso molecular: 548.06

Ref: TM-T2368L