CAS 484-43-5

(val5)-angiotensina I

Descripción:

(val5)-angiotensina I, también conocido como Angiotensina I, es una hormona péptida que juega un papel crucial en la regulación de la presión arterial y el equilibrio de fluidos en el cuerpo. Es un decapéptido compuesto por diez aminoácidos, específicamente derivado del precursor angiotensinaogen, que se produce en el hígado. La estructura de (val5)-angiotensina I incluye una secuencia de aminoácidos que contribuyen a su actividad biológica, principalmente a través de su interacción con los receptores de angiotensina. Este péptido es un componente clave del sistema renina-angiotensina, que es vital para la homeostasis cardiovascular. Su función principal es actuar como un sustrato para la enzima convertidora de angiotensina (ECA), que lo convierte en angiotensina II, un potente vasoconstrictor. El número CAS 484-43-5 identifica de manera única esta sustancia en bases de datos químicas, facilitando su estudio y aplicación en farmacología y medicina. En general, (val5)-angiotensina I es significativo tanto en procesos fisiológicos como en intervenciones terapéuticas relacionadas con la hipertensión y la insuficiencia cardíaca.

Fórmula: C₆₁H₈₇N₁₇O₁₄

InChI: InChI=1/C61H87N17O14/c1-32(2)22-40(62)51(82)71-43(25-37-28-65-30-68-37)53(84)74-45(24-35-12-8-7-9-13-35)59(90)78-21-11-15-47(78)56(87)72-44(26-38-29-66-31-69-38)55(86)77-50(34(5)6)58(89)73-42(23-36-16-18-39(79)19-17-36)54(85)76-49(33(3)4)57(88)70-41(14-10-20-67-61(63)64)52(83)75-46(60(91)92)27-48(80)81/h7-9,12-13,16-19,28-34,40-47,49-50,79H,10-11,14-15,20-27,62H2,1-6H3,(H,65,68)(H,66,69)(H,70,88)(H,71,82)(H,72,87)(H,73,89)(H,74,84)(H,75,83)(H,76,85)(H,77,86)(H,80,81)(H,91,92)(H4,63,64,67)/t40-,41-,42-,43-,44-,45-,46-,47-,49-,50-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CC(=O)O)C(=O)O)O)O)O)O)O)O)O)O)N

Sinónimos:

• Angiotensin I, val(5)-
• 5-Val-angiotensin I
• Angiotensin I, valine(5)-
• Angiotensin I, 5-L-valine-
• L-leucyl-L-histidyl-L-phenylalanyl-L-prolyl-L-histidyl-L-valyl-L-tyrosyl-L-valyl-N~5~-(diaminomethylidene)-L-ornithyl-L-aspartic acid

[Val5]-Angiotensin I (Bovine)

CAS: 484-43-5

[Val5]-Angiotensin I (Bovine) is a peptide that activates angiotensin receptors. It is used as a research tool in the study of ion channels and protein interactions. The antibody recognizes the C-terminal region of angiotensin I, which can be used to inhibit the activation of these receptors by preventing binding to their ligands.

Fórmula: C₆₁H₈₇N₁₇O₁₄•CH₃COOH•5H₂O

Pureza: Min. 95%

Peso molecular: 1,432.53 g/mol

Ref: 3D-PAN-4069-V

[Val5]-Angiotensin I (Bovine) (Bulk)

CAS: 484-43-5

Angiotensin I (Bovine) is a synthetic substrate that is used for the measurement of Angiotensin I-converting enzyme activity in vitro. It has been incubated with rat or bovine tissue and can be used as a chromatographic standard. This substrate binds to the active site of the enzyme and undergoes hydrolysis, which generates an increase in pH. The resulting product is then measured fluorimetrically by measuring the decrease in absorbance at 350 nm. This peptide has been found to have a pressor effect and an inhibitory effect on acid secretion.

Fórmula: C₆₁H₈₇N₁₇O₁₄•CH₃COOH•5H₂O

Pureza: Min. 95%

Peso molecular: 1,432.53 g/mol

Ref: 3D-PAN-4069

(Val5)-Angiotensin I trifluoroacetate salt

CAS: 484-43-5

Angiotensin I is a peptide that belongs to the class of substances called angiotensins. This substance is found in many tissues and organs, including the brain, adrenal gland, and lung. Angiotensin I has been shown to be a pressor agent and also has biochemical effects on amino acid composition. The c-terminal sequence of this substance has been determined by incubating the molecule with pepsin at different pH values. The molecular weight of this substance is 938 Da and it has an amino acid composition of Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu.

Fórmula: C₆₁H₈₇N₁₇O₁₄

Pureza: Min. 95%

Peso molecular: 1,282.45 g/mol

Ref: 3D-FV110212