CAS 486-56-6

Cotinina

Descripción:

Cotinina es un alcaloide que se encuentra de forma natural y es un metabolito principal de la nicotina, que se encuentra principalmente en el tabaco. Se clasifica como un derivado de la piridina y tiene una fórmula molecular de C10H12N2O. Cotinina es típicamente un líquido incoloro a amarillo pálido con un olor característico y es soluble en agua, alcohol y disolventes orgánicos. Su estructura presenta un anillo de piridina, que contribuye a sus propiedades farmacológicas. Cotinina se utiliza a menudo como un biomarcador para la exposición al tabaco debido a su vida media relativamente larga en comparación con la nicotina, lo que lo hace útil en estudios relacionados con la cesación del tabaquismo y el uso de tabaco. La sustancia exhibe efectos psicoactivos leves y se ha estudiado por sus posibles aplicaciones terapéuticas, incluidas propiedades neuroprotectoras. Además, se ha investigado el papel de Cotinina en la modulación de los efectos de la nicotina en el sistema nervioso central. Los datos de seguridad indican que Cotinina tiene baja toxicidad, pero sus efectos pueden variar según la dosis y la sensibilidad individual.

Fórmula: C₁₀H₁₂N₂O

InChI: InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

Clave InChI: InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N

SMILES: CN1[C@@H](CCC1=O)C=2C=CC=NC2

Sinónimos:

• (5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
• (5S)-1-Methyl-5-pyridin-3-ylpyrrolidin-2-one
• (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone
• (S)-Cotinine
• 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-
• 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-
• Cotinin
• Cotinina
• Nih 10498
• Cotinine

(-)-Cotinine 1.0 mg/ml in Methanol

CAS: 486-56-6

Forma y color: Single Solution

Ref: 61-AMP0517.03-01

Cotinine

CAS: 486-56-6

Forma y color: Neat

Ref: 61-FOR0517.03

Nicotine impurity standard

CAS: 486-56-6, 491-26-9, 51095-86-4, 532-12-7, 6019-06-3

Nicotine impurity standard

Forma y color: Off-White

Ref: 47-822

Nicotine Related Compound C ((S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one)

CAS: 486-56-6

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Fórmula: C₁₀H₁₂N₂O

Forma y color: White Off-White Powder

Peso molecular: 176.09496

Ref: 45-1463348

(-)-Cotinine

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Pureza: 98%

Forma y color: Solid

Peso molecular: 176.2151

Ref: IN-DA00DEPD

Cotinine

CAS: 486-56-6

Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.

Fórmula: C₁₀H₁₂N₂O

Pureza: 98% - 99.89%

Forma y color: Viscous Oil Solid

Peso molecular: 176.22

Ref: TM-T1202

(-)-Cotinine

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Peso molecular: 176.22

Ref: 7W-GL2462

Cotinine

CAS: 486-56-6

Cotinine

Pureza: ≥98%

Peso molecular: 176.22g/mol

Ref: 54-BUP11231

S-(-)-Cotinine

CAS: 486-56-6

S-(-)-Cotinine

Fórmula: C₁₀H₁₂N₂O

Pureza: ≥95%

Forma y color: pale orange low melting solid

Peso molecular: 176.22g/mol

Ref: 54-OR7251T

Cotinine (Nicotine EP Impurity C, Nicotine USP Related Compound C)

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Forma y color: Colorless Liquid

Peso molecular: 176.22

Ref: 4Z-C-551

Cotinine, 10mM (in DMSO)

CAS: 486-56-6

Cotinine, 10mM (in DMSO)

Pureza: ≥98%

Peso molecular: 176.22g/mol

Ref: 54-BUP19960

(-)-Cotinine

Producto controlado

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Forma y color: Neat

Peso molecular: 176.22

Ref: 04-C11708000

(5S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one ((-)-Cotinine)

Producto controlado

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Forma y color: Neat

Peso molecular: 176.22

Ref: 86-MM0517.03

(-)-Cotinine 100 µg/mL in Acetonitrile

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Forma y color: Single Solution

Peso molecular: 176.22

Ref: 04-A11708000AL-100

Nicotine EP Impurity C

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Peso molecular: 176.22

Ref: ST-EA-CP-N8003

S-(-)-Cotinine

Producto controlado

CAS: 486-56-6

Stability Hygroscopic
Applications S-(-)-Cotinine is a major metabolite of Nicotine (N412450) in humans. It is a carcinogen.This compound is a contaminant of emerging concern (CECs)
References Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986); Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996)

Fórmula: C₁₀H₁₂N₂O

Forma y color: Neat

Peso molecular: 176.22

Ref: TR-C725000

(S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Pureza: ≥98%

Peso molecular: 176.219

Ref: 10-F465111

S-(-)-Cotinine (1 mg/mL in Methanol)

CAS: 486-56-6

Fórmula: C₁₀H₁₂N₂O

Forma y color: Single Solution

Peso molecular: 176.22

Ref: TR-KIT0540

S-(-)-Cotinine

CAS: 486-56-6

Cotinine is a metabolite of nicotine that is found in the blood. It is used as a biomarker for exposure to tobacco products and has been shown to be an independent risk factor for cardiovascular disease. Cotinine can be detected in the blood, plasma, saliva, urine and breast milk with detection times of 24 hours to one week. Cotinine can also be measured in hair samples with detection times of 80 days or more. The measurement of cotinine levels in biological samples is complicated by the presence of other metabolites from nicotine metabolism and its high affinity for proteins such as albumin. It is important to account for these confounding factors when interpreting results from cotinine measurements. The most common method used to measure cotinine levels in biological samples is liquid chromatography-mass spectrometry (LC-MS/MS). This analytical method uses a mass spectrometer to separate and identify molecules based on their mass-to-charge ratio. A mouse monoclonal antibody

Fórmula: C₁₀H₁₂N₂O

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 176.22 g/mol

Ref: 3D-FC20565

(-)-Cotinine, 98%

CAS: 486-56-6

(-)-Cotinine is used to activate a subpopulation of 3/ 62 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodege

Fórmula: C₁₀H₁₂N₂O

Pureza: 98%

Forma y color: White to cream to yellow to pale brown, Fused solid : Clear liquid as melt

Peso molecular: 176.22

Ref: 02-L11873