CAS 490-82-4

3-[(4-Amino-2-metil-5-pirimidinil)metil]-5-(2-hidroxietil)-4-metil-2(3H)-tiazolona

Descripción:

La sustancia química conocida como 3-[(4-Amino-2-metil-5-pirimidinil)metil]-5-(2-hidroxietil)-4-metil-2(3H)-tiazolona, con el número CAS 490-82-4, es un derivado de tiazolona que exhibe una estructura molecular compleja. Presenta un anillo de tiazolona, que es un compuesto heterocíclico de cinco miembros que contiene azufre y nitrógeno, lo que contribuye a su actividad biológica. La presencia de un grupo pirimidina indica posibles interacciones con sistemas biológicos, particularmente en relación con el metabolismo de ácidos nucleicos. Este compuesto se caracteriza por sus grupos funcionales amino e hidroxietilo, que pueden mejorar la solubilidad y reactividad. A menudo se estudia por sus posibles propiedades farmacológicas, incluyendo actividades antimicrobianas y antitumorales. La estructura única del compuesto permite diversas modificaciones químicas, que pueden influir en su eficacia y perfil de seguridad en aplicaciones terapéuticas. Al igual que con muchos derivados de tiazolona, es esencial considerar su estabilidad, solubilidad y reactividad en diferentes entornos al evaluar sus usos prácticos en química medicinal.

Fórmula: C₁₂H₁₆N₄O₂S

InChI: InChI=1/C12H16N4O2S/c1-7-10(3-4-17)19-12(18)16(7)6-9-5-14-8(2)15-11(9)13/h5,17H,3-4,6H2,1-2H3,(H2,13,14,15)

Clave InChI: InChIKey=VXCONGLPCAPYEU-UHFFFAOYSA-N

SMILES: C(N1C(C)=C(CCO)SC1=O)C=2C(N)=NC(C)=NC2

Sinónimos:

• (3H)-Thiazolone, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-
• 2(3H)-Thiazolone, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-
• 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-(3H)-thiazolone
• 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolin-2-one
• 3-((4-Amino-2-metil-5-pirimidinil)metil)-5-(2-idrossietil)-4-metiltiazolin-2-one
• 3-((4-Amino-2-metil-5-pirimidinil)metil)-5-(2-idrossietil)-4-metiltiazolin-2-one [Italian]
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-2(3H)-thiazolone
• 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2(3H)-one
• 4-Thiazolin-2-one, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-
• Brn 0310984
• Thiamin thiazolone
• Thiamine thiazolone
• Thiaminthiazolone
• Tiamintiazolone
• Tiamintiazolone [Italian]
• 4-27-00-03500 (Beilstein Handbook Reference)
• 3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one
• 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazol-2-one
• 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2-one
• 3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2-one
• Oxo ThiaMine
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one

3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one

CAS: 490-82-4

Fórmula: C₁₂H₁₆N₄O₂S

Pureza: 95%

Forma y color: Solid

Peso molecular: 280.3460

Ref: IN-DA00DF4Z

Oxo thiamine

CAS: 490-82-4

Oxo thiamine

Pureza: 98%

Peso molecular: 280.35g/mol

Ref: 54-OR1007293

Thiamine EP Impurity D (Oxo Thiamine)

CAS: 490-82-4

Fórmula: C₁₂H₁₆N₄O₂S

Forma y color: White To Off-White Solid

Peso molecular: 280.35

Ref: 4Z-T-845

Thiamine EP Impurity D

CAS: 490-82-4

Fórmula: C₁₂H₁₆N₄O₂S

Peso molecular: 280.35

Ref: ST-EA-CP-T2004

Oxo Thiamine

CAS: 490-82-4

Applications Thiamine (T344185) impurity.
References Warnock, L., et al.: Anal. Biochem., 126, 394 (1982), Royer-Morrot, J., et al.: Eur. J. Clin. Pharmacol., 42, 219 (1992),

Fórmula: C₁₂H₁₆N₄O₂S

Forma y color: Off-White

Peso molecular: 280.35

Ref: TR-O864200

Oxo thiamine

CAS: 490-82-4

Oxo thiamine (OT) is a group II intramolecular hydrogen donor that has been shown to be effective against various types of cancer. OT is a competitive inhibitor of the bacterial enzyme sulfamidase, which is responsible for hydrolyzing sulfamethoxazole resulting in resistance to this antibiotic. In addition, OT inhibits mitochondrial complex I and causes a loss in mitochondrial membrane potential. OT also has anti-inflammatory properties and can be used as an analog in nuclear DNA synthesis. OT binds to the nitrogen atom on the phosphate group of ATP and forms a hydrogen bond with the oxygen atom on the same phosphate group, inhibiting enzymatic reactions.

Fórmula: C₁₂H₁₆N₄O₂S

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 280.35 g/mol

Ref: 3D-FO26662