CAS 50-02-2

Dexametasona

Descripción:

Dexametasona es un corticosteroide sintético con propiedades antiinflamatorias e inmunosupresoras, comúnmente utilizado en el tratamiento de diversas condiciones como alergias, enfermedades autoinmunes y ciertos tipos de cáncer. Su fórmula química es C22H29FO5, y presenta una estructura esteroide con un átomo de flúor y un grupo cetona, lo que contribuye a su potencia. Dexametasona actúa uniéndose a los receptores de glucocorticoides, influyendo en la expresión génica y modulando la respuesta inmune. Se administra típicamente por vía oral, intravenosa o mediante inyección, y sus efectos pueden incluir reducción de la inflamación y supresión del sistema inmunológico. La sustancia es conocida por su vida media relativamente larga en comparación con otros corticosteroides, lo que permite una dosificación menos frecuente. Los efectos secundarios pueden incluir aumento de peso, cambios de humor y mayor riesgo de infecciones, particularmente con el uso prolongado. Dexametasona también es notable por su papel en el manejo de casos severos de COVID-19, donde se ha demostrado que mejora los resultados en pacientes que requieren oxígeno o ventilación mecánica.

Fórmula: C₂₂H₂₉FO₅

InChI: InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16+,17+,19+,20+,21+,22+/m1/s1

Clave InChI: InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Sinónimos:

• (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• (8Xi,11Beta,16Alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 1-Dehydro-16α-methyl-9α-fluorohydrocortisone
• 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 16α-Methyl-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
• 16α-Methyl-9α-fluoro-Δ1-hydrocortisone
• 16α-Methyl-9α-fluoro-Δ¹-hydrocortisone
• 16α-Methyl-9α-fluoroprednisolone
• 9-Alpha-Fluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 9-Alpha-Fluoro-16-Alpha-Methylprednisolone
• 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
• 9α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 9α-Fluoro-16α-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-16α-methylprednisolone
• Adexone
• Aeroseb-Dex
• Aphtasolon
• Aphthasolone
• Azium
• Calonat
• Corsone
• Cortisumman
• Decacort
• Decaderm
• Decadron
• Decalix
• Decasone
• Dekacort
• Dekort
• Delipos
• Deltafluorene
• Dergramin
• Deronil
• Desadrene
• Desameton
• Deseronil
• Dexa-Cortidelt
• Dexa-Mamallet
• Dexa-Scheroson
• Dexa-sine
• Dexacort
• Dexacortal
• Dexacortin
• Dexadeltone
• Dexafarma
• Dexalona
• Dexaltin
• Dexametasona
• Dexameth
• Dexamethason
• Dexamonozon
• Dexapolcort
• Dexapos
• Dexaprol
• Dexaratiopharm
• Dexason
• Dexasone
• Dexaven
• Dexinoral
• Dexium
• Dexmethsone
• Dexone
• Dexonium
• Dextelan
• Dinormon
• Diodex
• Etacortilen
• Fluormethylprednisolone
• Fluormone
• Fluorocort
• Gammacorten
• Gentalipos
• HL-Dex
• Hexadecadrol
• Hexadrol
• Isopto-Dex
• Loverine
• Luxazone
• Maxidex
• Millicorten
• Minidex
• Neofordex
• Oftan
• Oradexon
• Ozurdex
• Posurdex
• Superprednol
• Surodex
• Visumetazone
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16α)-
• MK 125
• DEXAMETHASONE BASE
• DEXAMETHASONE
• (11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE
• 1,4-PREGNADIENE-3,20-DIONE-9ALPHA-FLUORO-16ALPHA METHYL-11BETA,17ALPHA,21-TRIOL
• 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
• 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
• 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE
• PREDNISOLONE F
• (11BETA,16ALPHA)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
• 1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE
• DECACORTIN
• 9ALPHA-FLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYL-1,4-PREGNADIENE 3,20DIONE

Dexamethasone-d3

Producto controlado

CAS: 50-02-2

Applications Dexamethasone-d3 is the labelled form of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Fórmula: C₂₂H₂₆D₃FO₅

Forma y color: Off-White To Light Beige

Peso molecular: 395.48

Ref: TR-D298803

Dexamethasone Acetate EP Impurity A

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Peso molecular: 392.47

Ref: ST-EA-CP-D17031

Dexamethasone

Producto controlado

CAS: 50-02-2

Impurity Dexamethasone Sodium Phosphate EP Impurity A
Applications Dexamethasone (Dexamethasone Sodium Phosphate EP Impurity A) is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Fórmula: C₂₂H₂₉FO₅

Forma y color: Neat

Peso molecular: 392.46

Ref: TR-D298800

Dexamethasone Sodium phosphate EP Impurity A

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Peso molecular: 392.47

Ref: ST-EA-CP-D105001

Betamethasone EP Impurity A

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Peso molecular: 392.46

Ref: ST-EA-CP-B25001

Dexamethasone 21-Formate

Producto controlado

CAS: 50-02-2

Applications Dexamethasone 21-Formate is a metabolite of Dexamethasone.
References Minagawa, K., et al.: Steroids, 47, 175 (1986), Murray, G., et al.: Br. J. Clin. Pharmacol., 25, 465 (1988), Ravichandran, K., et al.: Science, 1993, 261, 731 (1993),

Fórmula: C₂₃H₂₉FO₆

Forma y color: Neat

Peso molecular: 420.47

Ref: TR-D298910

Dexamethasone base

Producto controlado

CAS: 50-02-2

Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is often used to treat various ocular conditions, such as macular edema, retinal detachment, and uveitis. Dexamethasone has been shown to inhibit the migration of leukocytes into the vitreous humor of the eye by binding to glucocorticoid receptors in the cells that line blood vessels in the retina. Dexamethasone also binds to signal peptides on proteins that regulate mitochondrial functions and glucose uptake in cells. This drug can be used for bowel disease treatment, chronic cough management, or as an injection during polymerase chain reactions.

Fórmula: C₂₂H₂₉FO₅

Pureza: Min. 96 Area-%

Forma y color: Powder

Peso molecular: 392.46 g/mol

Ref: 3D-FD15640

Dexamethasone Regiomer

Producto controlado

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Forma y color: Neat

Peso molecular: 392.47

Ref: TR-D358235

DEXAMETHASONE

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 392.4611

Ref: IN-DA0034OW

Dexamethasone 1.0 mg/ml in Methanol

CAS: 50-02-2

Forma y color: Single Solution

Ref: 61-AMP0213.00-01