CAS 50-63-5

(±)-Dihidrogenofosfato de cloroquina

Descripción:

(±)-Dihidrogenofosfato de cloroquina es un compuesto sintético conocido principalmente por su uso como agente antipalúdico. Pertenece a la clase de las 4-aminoquinolinas y se caracteriza por su capacidad para interferir con el crecimiento del parásito de la malaria al inhibir la polimerización de hemo, lo cual es crucial para la supervivencia del parásito. El compuesto exhibe una naturaleza quiral, con dos enantiómeros, que pueden influir en su actividad farmacológica y efectos secundarios. Además de sus propiedades antipalúdicas, se ha investigado la cloroquina por sus posibles efectos antivirales y como agente inmunomodulador en diversas enfermedades autoinmunitarias. La forma de sal diphosphato mejora su solubilidad y estabilidad en soluciones acuosas, lo que la hace adecuada para formulaciones farmacéuticas. La cloroquina se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite una dosificación una vez al día en algunos casos. Sin embargo, su uso se ha asociado con efectos secundarios, incluidos trastornos gastrointestinales y potencial toxicidad retinal con el uso a largo plazo. Al igual que con cualquier medicamento, es esencial considerar cuidadosamente sus beneficios y riesgos en entornos clínicos.

Fórmula: C₁₈H₃₂ClN₃O₈P₂

InChI: InChI=1/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

Clave InChI: InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N

SMILES: P(=O)(O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinónimos:

• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-, phosphate (1:2)
• 3377 Rp
• 3377Rp
• 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
• 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
• 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
• Ai3-14952
• Alermine
• Alexoquine
• Aralen diphosphate
• Aralen phosphate
• Arechin
• Avloclor
• Bemaphate
• Chingamin
• Chingamin phosphate
• Chlorochin diphosphate
• Chloroquin diphosphate
• Chloroquine bis(phosphate)
• Chloroquine dihydrogen phosphate (1:2)
• Chloroquine phosphate
• Cidoquine
• Delagil
• Gontochin phosphate
• Imagon
• Khingamin
• Maladrin
• Malaquin
• NSC 14050
• Nivaquine B
• N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine phosphate (1:2)
• Quingamine
• Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, phosphate (1:2) (8CI)
• Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
• Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-, phosphate (1:2)
• Quivaclor
• Resochin
• Resoquine
• Sanoquin
• Sn 7618
• Tanakan
• Tanakan (antimalarial)
• Tresochin
• Unii-6E17K3343P
• Wr 1522
• chloroquin Phosphate
• dl-Chloroquine diphosphate
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2)
• 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-quinolindiphosphate
• 7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID
• N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE SALT
• gontochinphosphate
• chingaminphosphate
• klorokinfosfat
• h-stadur
• CHLOROQUINE DIPHOSPHATE SALT
• chloroquindiphosphate
• 7-chloro-4-((4’-diethylamino-1-methylbutyl)amino)quinolinediphosphate
• chloroquinebis(phosphate)
• aralendiphosphate
• N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE
• n-(7-chloro-4-quinolinyl)-n,n-dimethyl-1,4-pentanediamine diphosphate salt

Chloroquine Diphosphate

CAS: 50-63-5

Fórmula: C₁₈H₂₆ClN₃·2H₃PO₄

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 515.86

Ref: 3B-C2301

Chloroquine diphosphate salt, 98%

CAS: 50-63-5

Chloroquine diphosphate salt, 50-63-5, is a non-steroidal agent and DNA intercalator which exhibits antimalarial and anti-inflammatory properties. Learn more.

Fórmula: C₁₈H₃₂ClN₃O₈P₂

Pureza: 98%

Forma y color: Powder or crystals or crystalline powder, White to off-white

Peso molecular: 515.86

Ref: 02-J64459

Chloroquine Phosphate

CAS: 50-63-5

Forma y color: Neat

Ref: 61-FOR1055.00

CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS

CAS: 50-63-5

CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002448

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate

Fórmula: C₁₈H₂₆ClN₃H₃PO₄

Pureza: 98.4%

Forma y color: Light Brown

Peso molecular: 417.15842

Ref: 47-1314

Chloroquine Phosphate

CAS: 50-63-5

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Fórmula: C₁₈H₂₆ClN₃·2H₃PO₄

Forma y color: Yellow Powder

Peso molecular: 515.86

Ref: 45-1118000

Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)

CAS: 50-63-5

Fórmula: C₁₈H₃₀ClN₃O₇P₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 497.8472

Ref: IN-DA0034LP

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.

Fórmula: C₁₈H₂₆CLN₃·2(H₃PO₄)

Pureza: 99.64% - ≥95%

Forma y color: White To Slightly Yellow Crystalline Powder White Solid

Peso molecular: 515.87

Ref: TM-T0194

Chloroquine diphosphate salt

CAS: 50-63-5

Fórmula: C₁₈H₂₆ClN₃·2H₃PO₄

Pureza: (Titration) 98.0 - 102.0 % (dried basis)

Forma y color: White or almost white crystalline powder

Peso molecular: 515.87

Ref: 7W-GA7477

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate

Pureza: ≥95%

Peso molecular: 515.87g/mol

Ref: 54-BUP17400

Chloroquine Diphosphate

CAS: 50-63-5

Fórmula: C₁₈H₂₆ClN₃·2H₃O₄P

Forma y color: White To Off-White Solid

Peso molecular: 319.88 2*97.99

Ref: 4Z-C-921

Chloroquine-d5 Diphosphate

CAS: 50-63-5

Fórmula: C₁₈H₂₁D₅ClN₃·2H₃O₄P

Forma y color: White To Off-White Solid

Peso molecular: 324.91 2*97.99

Ref: 4Z-C-922

Chloroquine Phosphate

CAS: 50-63-5

Forma y color: Neat

Ref: 86-MM1055.00

Chloroquine diphosphate

CAS: 50-63-5

Fórmula: C₁₈H₂₆ClN₃H₃O₄P

Forma y color: Neat

Peso molecular: 515.86

Ref: 04-C11506000

Chloroquine diphosphate

CAS: 50-63-5

Chloroquine diphosphate

Peso molecular: 515.86g/mol

Ref: 54-BISN0106

Chloroquine-d4 Phosphate Salt

Producto controlado

CAS: 1246815-14-4, 50-63-5

Applications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.
References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),

Fórmula: C₁₈H₂₂D₄ClN₃•xH₃PO₄

Forma y color: Yellow Solid

Peso molecular: 323.9098

Ref: TR-C379967

Chloroquine diphosphate salt

CAS: 50-63-5

Stability Hygroscopic
Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.
References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),

Fórmula: C₁₈H₂₆ClN₃·2H₃O₄P

Forma y color: Light Brown

Peso molecular: 515.86

Ref: TR-C379965

Chloroquine Diphosphate Salt

CAS: 50-63-5

Fórmula: C₁₈H₂₆ClN₃(H₃PO₄)

Peso molecular: 319.9 : 2(98.0)

Ref: ST-EA-CP-C69001

Chloroquine diphosphate

Producto controlado

CAS: 50-63-5

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine i a schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the S-glycoprotein.

Fórmula: C₁₈H₃₂ClN₃O₈P₂

Forma y color: White Off-White Powder

Peso molecular: 515.86 g/mol

Ref: 3D-FC20382

Chloroquine Diphosphate

CAS: 50-63-5

Fórmula: C₁₈H₃₂ClN₃O₈P₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 515.86

Ref: 10-F358020