CAS 516-42-7

Cortolone

Descripción:

Cortolone, con el número CAS 516-42-7, es un corticosteroide sintético que exhibe propiedades antiinflamatorias e inmunosupresoras. Se deriva de la cortisona y se utiliza principalmente en el tratamiento de diversas condiciones inflamatorias, como la artritis y los trastornos de la piel. Cortolone funciona modulando la respuesta inmune e inhibiendo la liberación de mediadores inflamatorios. La sustancia se caracteriza por su estructura esteroidal, que incluye un núcleo de cuatro anillos típico de las hormonas esteroides, lo que contribuye a su actividad biológica. Cortolone se administra típicamente en varias formas, incluidas aplicaciones tópicas y formulaciones sistémicas, dependiendo de la condición que se trate. Su farmacocinética implica un metabolismo principalmente en el hígado, con excreción a través de la orina. Aunque es efectivo, Cortolone puede tener efectos secundarios, incluidos posibles impactos en el metabolismo de la glucosa, el equilibrio de electrolitos y una mayor susceptibilidad a infecciones, lo que requiere un monitoreo cuidadoso durante la terapia. Al igual que con todos los corticosteroides, su uso debe ser guiado por un profesional de la salud para equilibrar los beneficios terapéuticos con los posibles efectos adversos.

Fórmula: C₂₁H₃₄O₅

InChI: InChI=1/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12?,13-,14+,15+,17-,18-,19+,20+,21+/m1/s1

Clave InChI: InChIKey=JXCOSKURGJMQSG-AZQJGLEESA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C(=O)C1)[H])[H])(CC[C@@]2([C@H](CO)O)O)[H]

Sinónimos:

• (3alpha,5beta,20S)-3,17,20,21-tetrahydroxypregnan-11-one
• (3α,5β,20S)-3,17,20,21-Tetrahydroxypregnan-11-one
• 20alpha-Cortolone
• 20α-Cortolone
• 3alpha,17alpha,20alpha,21-Tetrahydroxy-5beta-pregnan-11-one
• 3α,17,20α,21-Tetrahydroxy-5β-pregnan-11-one
• 3α,17α,20α,21-Tetrahydroxy-5β-pregnan-11-one
• 5beta-Pregnan-11-one, 3alpha,17,20alpha,21-tetrahydroxy- (8CI)
• 5beta-Pregnane-3alpha,17,20alpha,21-tetrol-11-one
• 5β-Pregnan-11-one, 3α,17,20α,21-tetrahydroxy-
• 5β-Pregnan-3α,17α,20α,21-tetrol-11-one
• 5β-Pregnane-3α,17,20α,21-tetrol-11-one
• 5β-Pregnane-3α,17α,20α,21-tetrol-11-one
• Cortolon
• Cortolone
• Nsc 59872
• Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3alpha,5beta,20S)- (9CI)
• Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20S)-
• α-Cortolone
• A-cortolone crystalline
• 3-ALPHA,17-ALPHA,20-ALPHA,21-TETRAHYDROXY-5-BETA-PREGNAN-11-ONE
• α-Cortolone-d5
• ALPHA-CORTOLONE
• Alpha Cortolone D5
• 5β-Pregnan-3α, 17, 20α, 21-Tetrol-11-One
• (20S)-3α,17,20,21-Tetrahydroxy-5β-pregnan-11-one
• 5-BETA-PREGNAN-3-ALPHA, 17,20-ALPHA, 21-TETROL-11-ONE
• (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1S)-1,2-dihydroxyethyl]-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one

α-Cortolone

Producto controlado

CAS: 516-42-7

Applications α-Cortolone is a human urinary metabolite of Cortisol ((H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Yergey, A.L., et. al.: Steroids, 60, 295 (1995); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

Fórmula: C₂₁H₃₄O₅

Forma y color: Neat

Peso molecular: 366.49

Ref: TR-C696280

α-Cortolone

CAS: 516-42-7

α-Cortolone, a metabolite of the glucocorticoid cortisol (hydrocortisone), is produced through the action of 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE) intermediate. Studies indicate that urinary levels of α-cortolone are reduced in patients experiencing severe anorexia nervosa and postmenopausal women diagnosed with endometrial adenocarcinoma, in comparison to postmenopausal women without the condition.

Fórmula: C₂₁H₃₄O₅

Forma y color: Solid

Peso molecular: 366.49

Ref: TM-T84945

Alpha-cortolone

CAS: 516-42-7

Alpha-cortolone is a corticosteroid metabolite, which is a biochemically derived product from the metabolism of cortisol. It is produced in the body through the enzymatic reduction of cortisol, a hormone significantly involved in the stress response, metabolism, and immune function. The mode of action for alpha-cortolone primarily involves its role as a metabolite in the complex steroid hormone pathway. It can influence the regulation of various physiological functions due to its origin from cortisol.

Fórmula: C₂₁H₃₄O₅

Pureza: Min. 95%

Peso molecular: 366.5 g/mol

Ref: 3D-AAA51642