CAS 51798-45-9

Elastatinal

Descripción:

Elastatinal es un compuesto químico clasificado como un péptido cíclico, específicamente un miembro de los inhibidores de elastasa. Se deriva de fuentes naturales, particularmente de ciertas especies de hongos. El compuesto exhibe una notable actividad biológica, principalmente como un inhibidor de la elastasa, una enzima que descompone la elastina, una proteína clave en los tejidos conectivos. Esta inhibición puede tener implicaciones en varios procesos fisiológicos y aplicaciones terapéuticas potenciales, particularmente en condiciones caracterizadas por una actividad excesiva de elastasa, como la enfermedad pulmonar obstructiva crónica (EPOC) y ciertos trastornos inflamatorios. Elastatinal se caracteriza por su estructura cíclica única, que contribuye a su estabilidad y especificidad en la unión a la elastasa. Además, se ha estudiado por su posible papel en el desarrollo de fármacos debido a su capacidad para modular la actividad proteolítica. Al igual que muchos compuestos bioactivos, se necesita más investigación para comprender completamente sus mecanismos de acción, farmacocinética y posibles efectos secundarios en entornos clínicos.

Fórmula: C₂₁H₃₆N₈O₇

InChI: InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

Clave InChI: InChIKey=IJWCGVPEDDQUDE-YGJAXBLXSA-N

SMILES: [C@H](C(N[C@H](C(N[C@H](C=O)C)=O)CCC(N)=O)=O)(NC(N[C@@H](CC(C)C)C(O)=O)=O)[C@]1(NC(N)=NCC1)[H]

Sinónimos:

• (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-<span class="text-smallcaps">L</span>-glutamamide
• (2S,6S,9S,12S)-9-(3-amino-3-oxopropyl)-6-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• (2S,9S)-9-(3-amino-3-oxopropyl)-6-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• 9-(3-Amino-3-Oxopropyl)-6-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-12-Methyl-2-(2-Methylpropyl)-4,7,10,13-Tetraoxo-3,5,8,11-Tetraazatridecan-1-Oic Acid (Non-Preferred Name)
• <span class="text-smallcaps">L</smallcap>-Glutamamide, <smallcap>L</span>-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N¹-(1-methyl-2-oxoethyl)-, stereoisomer
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• Elastatinal
• N~2~-[(2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-2-({[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}amino)acetyl]-N~1~-[(2S)-1-oxopropan-2-yl]-L-glutamamide
• L-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-, stereoisomer

Elastatinal

CAS: 51798-45-9

Fórmula: C₂₁H₃₆N₈O₇

Pureza: 85%

Peso molecular: 512.5599

Ref: IN-DA01E4MS

Elastatinal

CAS: 51798-45-9

Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.

Fórmula: C₂₁H₃₆N₈O₇

Forma y color: Yellowish Solid

Peso molecular: 512.56

Ref: TM-T20130

Elastatinal microbial

CAS: 51798-45-9

Fórmula: C₂₁H₃₆N₈O₇

Pureza: ~0.64μg/ml (IC50, pH8.8, 37°C)

Forma y color: White to light-yellow or tan powder

Peso molecular: 512.60

Ref: 7W-GL1320

Elastatinal

CAS: 51798-45-9

Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and vaginal secretions. Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and

Fórmula: C₂₁H₃₆N₈O₇

Pureza: Min. 95%

Peso molecular: 512.56 g/mol

Ref: 3D-IEL-4064

Elastatinal

Producto controlado

CAS: 51798-45-9

Applications Elastatinal is an elastase inhibitor.

Fórmula: C₂₁H₃₆N₈O₇

Forma y color: Neat

Peso molecular: 512.56

Ref: TR-E501008

Elastatinal

CAS: 51798-45-9

Elastatinal is a research tool that is used to activate cells by binding to a receptor on the cell surface. Elastatinal belongs to the Ligand class of compounds and has been shown to bind to various ion channels and receptors, including cell surface receptors. This ligand binds with high affinity to the α-adrenergic receptor (α-AR) and activates cells that express this receptor. It also inhibits the binding of other ligands, such as bradykinin, which may be useful in pharmacology. Elastatinal is an inhibitor of protein interactions, which can be used in Cell Biology studies.

Fórmula: C₂₁H₃₆N₈O₇

Pureza: Min. 95%

Peso molecular: 512.56 g/mol

Ref: 3D-IEL-4064-V

Elastatinal

CAS: 51798-45-9

Irreversible elastase inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Fórmula: C₂₁H₃₆N₈O₇

Peso molecular: 512.6

Ref: 02-J61120