CAS 52-01-7

Espironolactona

Descripción:

Espironolactona es un compuesto esteroide sintético que se utiliza principalmente como diurético y agente antihipertensivo. Funciona como un antagonista de la aldosterona, inhibiendo la acción de la aldosterona en los riñones, lo que promueve la excreción de sodio y agua mientras conserva potasio. Este mecanismo lo hace efectivo en el tratamiento de condiciones como la hipertensión, la insuficiencia cardíaca y ciertos casos de edema. Espironolactona también se utiliza en el manejo de condiciones como el hiperaldosteronismo y puede ser beneficioso en el tratamiento del acné y el hirsutismo debido a sus propiedades antiandrogénicas. El compuesto se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite una dosificación una vez al día en muchos casos. En términos de su estructura química, Espironolactona presenta un anillo de lactona y un grupo tioéster, lo que contribuye a su actividad farmacológica. Los efectos secundarios comunes pueden incluir hiperkalemia, trastornos gastrointestinales y desequilibrios hormonales. Debido a sus efectos hormonales, Espironolactona a veces se utiliza fuera de etiqueta en la terapia hormonal para personas transgénero. En general, Espironolactona es un medicamento versátil con aplicaciones terapéuticas significativas en diversas condiciones médicas.

Fórmula: C₂₄H₃₂O₄S

InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

Clave InChI: InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Sinónimos:

• (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
• 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
• 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
• 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
• 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
• 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
• 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
• 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
• 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
• 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
• Abbolactone
• Aldace
• Aldactone
• Aldactone A
• Aldopur
• Almatol
• Altex
• Aquareduct
• Berlactone
• Deverol
• Diatensec
• Dira
• Duraspiron
• Espironolactona
• Euteberol
• Lacalmin
• Lacdene
• Laractone
• Nefurofan
• Novo-Spiroton
• Nsc 150399
• Osiren
• Osyrol
• Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
• Quimolactona
• S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
• S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• Sagisal
• Sc 9420
• Sincomen
• Spiresis
• Spiretic
• Spiridon
• Spiro-Tablinen
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
• Spiroctan
• Spiroderm
• Spirolactone
• Spirolang
• Spirolone
• Spirone
• Spironol
• Spironolacton
• Spironolactone A
• Supra-Puren
• Suracton
• Uractone
• Urusonin
• Verospiron
• Verospirone
• Xenalon

Spironolactone

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 416.58

Ref: 3B-S0260

Spironolactone

CAS: 52-01-7

Spironolactone used as potassium sparing diuretic. Also used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation

Fórmula: C₂₄H₃₂O₄S

Forma y color: White solid

Peso molecular: 416.58

Ref: 02-J60119

Spironolactone 1.0 mg/ml in Acetonitrile

CAS: 52-01-7

Forma y color: Single Solution

Ref: 61-AMP0197.00-11

Spironolactone

CAS: 52-01-7

Forma y color: Neat

Ref: 61-FOR0197.00

SPIRONOLACTONE CRS

CAS: 52-01-7

SPIRONOLACTONE CRS

Fórmula: C₂₄H₃₂O₄S

Forma y color: Powder

Peso molecular: 416.5735

Ref: 41-S1200000

SPIRONOLACTONE RS

CAS: 52-01-7

SPIRONOLACTONE RS

Fórmula: C₂₄H₃₂O₄S

Forma y color: Powder

Peso molecular: 416.5735

Ref: 41-ICRS49241

Spironolactone

CAS: 52-01-7

Spironolactone

Fórmula: C₂₄H₃₂O₄S

Pureza: 99.3%

Forma y color: Off-White

Peso molecular: 416.20213

Ref: 47-306

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

CAS: 52-01-7

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

Forma y color: Powder

Ref: 41-Y0001295

Spironolactone

CAS: 52-01-7

Adrenal cortical hormones and their derivatives nesoi

Fórmula: C₂₄H₃₂O₄S

Forma y color: White Light Cream Powder

Peso molecular: 416.20213

Ref: 45-1619006

Spironolactone

CAS: 52-01-7

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Fórmula: C₂₄H₃₂O₄S

Pureza: 99.87%

Forma y color: White Powder

Peso molecular: 416.57

Ref: TM-T0476

Spironolactone

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Forma y color: Off-White Solid

Peso molecular: 416.58

Ref: 4Z-S-083

Spironolactone, Ph. Eur. grade

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: ≤ 0.1%

Forma y color: White or pale yellow powder

Peso molecular: 416.58

Ref: 7W-GP2110

Spironolactone-d3 (7-Acetylthio-d3)

CAS: 52-01-7

Fórmula: C₂₄H₂₉D₃O₄S

Peso molecular: 419.59

Ref: 4Z-S-0823

Spironolactone

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: (HPLC) ≥ 97.0%

Forma y color: White to off-white powder

Peso molecular: 416.58

Ref: 7W-GP5407

Spironolactone-d3 (Major)

CAS: 52-01-7

Fórmula: C₂₄H₂₉D₃O₄S

Forma y color: Off-White To Pale Yellow Solid

Peso molecular: 419.59

Ref: 4Z-S-082

Spironolactone

CAS: 52-01-7

Spironolactone

Pureza: ≥95%

Peso molecular: 416.579g/mol

Ref: 54-OR98301

Spironolactone

Producto controlado

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Forma y color: Neat

Peso molecular: 416.57

Ref: 04-C16972980

Spironolactone

CAS: 52-01-7

Forma y color: Neat

Ref: 86-MM0197.00

Sugammadex Impurity 77

CAS: 52-01-7

Fórmula: C₈₇H₁₁₄O₄₈PS₇·7Na

Forma y color: Off-White To Pale Yellow Solid

Peso molecular: 2183.22 7*22.99

Ref: 4Z-S-082080

Spironolactone RS

CAS: 52-01-7

Forma y color: White

Ref: 2K-1074000021

Spironolactone-d3

Producto controlado

CAS: 52-01-7

Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975)

Fórmula: C₂₄H₂₉D₃O₄S

Forma y color: Yellow Solid

Peso molecular: 419.59

Ref: TR-S683003

Spironolactone

Producto controlado

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Fórmula: C₂₄H₃₂O₄S

Forma y color: Off-White

Peso molecular: 416.57

Ref: TR-S683000

Spironolactone-d7 (Major)

Producto controlado

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. A representative lot was 19% d3; 47% d6; 12% d7; 7% d8; 3% d9; 3% d10 and 8% d11.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Fórmula: C₂₄H₂₅D₇O₄S

Forma y color: Neat

Peso molecular: 423.62

Ref: TR-S683002

Spironolactone

Producto controlado

CAS: 52-01-7

Mineralocorticoid (aldosterone) receptor antagonist; anti-hypertensive

Fórmula: C₂₄H₃₂O₄S

Pureza: Min. 97 Area-%

Forma y color: White Powder

Peso molecular: 416.57 g/mol

Ref: 3D-FS15791

Spironolactone - Bio-X ™

Producto controlado

CAS: 52-01-7

Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.

Fórmula: C₂₄H₃₂O₄S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 416.57 g/mol

Ref: 3D-BS166385

Spironolactone extrapure, 97%

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: min. 97%

Forma y color: White, Powder

Peso molecular: 416.60

Ref: SR-67715

17-Hydroxy-7-α-mercapto-3-oxo-17-α-pregn-4-ene-21-carboxylic acid-γ-lactone-7-acetate

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: 97%

Forma y color: Solid

Peso molecular: 416.5735

Ref: IN-DA00DE6I