CAS 522-17-8

Deguelina

Descripción:

Deguelina es un compuesto que se encuentra de forma natural clasificado como un flavonoide, específicamente un miembro de la familia de los rotenoides. Se deriva principalmente de varias especies de plantas, particularmente aquellas de la familia Fabaceae. Deguelina exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, anticancerígenas y antidiabéticas, lo que lo convierte en un tema de interés en la investigación farmacológica. Se ha demostrado que el compuesto inhibe ciertas enzimas y vías involucradas en la proliferación y supervivencia de células cancerosas. Químicamente, Deguelina se caracteriza por su estructura compleja, que incluye múltiples anillos y grupos funcionales que contribuyen a su reactividad y actividad biológica. Se encuentra típicamente en forma sólida a temperatura ambiente y es soluble en disolventes orgánicos. Debido a sus posibles beneficios terapéuticos, Deguelina ha atraído la atención en los campos de la química medicinal y la investigación de productos naturales, aunque se necesitan más estudios para comprender completamente sus mecanismos de acción y aplicaciones potenciales en entornos clínicos.

Fórmula: C₂₃H₂₂O₆

InChI: InChI=1/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1

Clave InChI: InChIKey=ORDAZKGHSNRHTD-UXHICEINSA-N

SMILES: O=C1C=2C(=C3C(=CC2)OC(C)(C)C=C3)O[C@]4([C@@]1(C=5C(OC4)=CC(OC)=C(OC)C5)[H])[H]

Sinónimos:

• (-)-cis-Deguelin
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-on
• (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-pyrano[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• Deguelin
• (7aS,13aS)-9,10-Diméthoxy-3,3-diméthyl-13,13a-dihydro-3H-chroméno[3,4-b]pyrano[2,3-h]chromén-7(7aH)-one
• (7aS)-3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (7AS,13AS)-13,13A-DIHYDRO-9,10-DIMETHOXY-3,3-DIMETHYL-3H-BIS[1]BENZOPYRANO[3,4-B:6',5'-E]PYRAN-7(7AH)-ONE
• (7as-cis)-oxy-
• 3h-bis(1)benzopyrano(3,4-b:6’,5’-e)pyran-7(7ah)-one,13,13a-dihydro-9,10-dimeth
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one
• 3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (-)-DEGUELIN;(-)-CIS-DEGUELIN
• Deguelin (6CI)
• 12a-DEOXYTEPHROSIN
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-(3H)-bis[1]benzopyrano[3.4-b.6'.5'-e]pyran-7(7aH)-one

Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 394.4172

Ref: IN-DA00D7ZC

Deguelin

CAS: 522-17-8

Deguelin

Pureza: ≥95%

Peso molecular: 394.42g/mol

Ref: 54-BUP10439

(-)-Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: ≥ 98.0%

Forma y color: White to beige powder

Peso molecular: 394.42

Ref: 7W-GL4230

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

CAS: 522-17-8

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

Pureza: 98%

Peso molecular: 394.42g/mol

Ref: 54-OR1026149

Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: 95%~99%

Forma y color: Powder

Peso molecular: 394.423

Ref: BP-BP3110

Deguelin

CAS: 522-17-8

Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.

Fórmula: C₂₃H₂₂O₆

Pureza: 96.39% - 99.29%

Forma y color: Solid

Peso molecular: 394.42

Ref: TM-T6817

Deguelin

CAS: 522-17-8

Oxygen-heterocyclic compound

Fórmula: C₂₃H₂₂O₆

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 394.42

Ref: 5G-22641

Deguelin

Producto controlado

CAS: 522-17-8

Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);

Fórmula: C₂₃H₂₂O₆

Forma y color: Light Yellow

Peso molecular: 394.42

Ref: TR-D229205

(-)-Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: >95.0%(HPLC)

Forma y color: White to Yellow to Green powder to crystal

Peso molecular: 394.42

Ref: 3B-D5646

Deguelin

CAS: 522-17-8

Deguelin is a rotenoid, which is a naturally occurring compound derived primarily from the roots of plants in the Leguminosae family, such as Mundulea sericea and Derris species. It functions as a potent inhibitor of mitochondrial complex I, interfering with cellular respiration by blocking electron transport within the mitochondrial electron transport chain. This action leads to the inhibition of ATP production, which is essential for cellular energy.

Fórmula: C₂₃H₂₂O₆

Pureza: Min. 95%

Peso molecular: 394.42 g/mol

Ref: 3D-FD65404

DEGUELIN

CAS: 522-17-8

Pureza: 98%

Peso molecular: 394.4230042

Ref: 10-F814502